- MeSH
- apendektomie MeSH
- apendix * anatomie a histologie imunologie růst a vývoj MeSH
- ekologie a životní prostředí - jevy MeSH
- lidé MeSH
- primáti MeSH
- savci MeSH
- střevní mikroflóra MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- přehledy MeSH
Lipid membrane remodeling belongs to the most fundamental processes in the body. The skin barrier lipids, which are ceramide dominant and highly rigid, must attain an unusual multilamellar nanostructure with long periodicity to restrict water loss and prevent the entry of potentially harmful environmental factors. Our data suggest that the skin acid mantle, apart from regulating enzyme activities and keeping away pathogens, may also be a prerequisite for the multilamellar assembly of the skin barrier lipids. Atomic force microscopy on monolayers composed of synthetic or human stratum corneum lipids showed multilayer formation (approximately 10-nm step height) in an acidic but not in a neutral environment. X-ray diffraction, Fourier transform infrared spectroscopy, and permeability studies showed markedly altered lipid nanostructure and increased water loss at neutral pH compared with that at acidic pH. These findings are consistent with the data on the altered organization of skin lipids and increased transepidermal water loss under conditions such as inadequate skin acidification, for example, in neonates, the elderly, and patients with atopic dermatitis.
- MeSH
- atopická dermatitida patologie MeSH
- ceramidy chemie metabolismus MeSH
- cholesterol chemie metabolismus MeSH
- difrakce rentgenového záření MeSH
- epidermis chemie metabolismus patologie MeSH
- koncentrace vodíkových iontů MeSH
- kyseliny mastné neesterifikované chemie metabolismus MeSH
- lidé MeSH
- mastné kyseliny MeSH
- mikroskopie atomárních sil MeSH
- novorozenec MeSH
- permeabilita MeSH
- perspiratio insensibilis * MeSH
- senioři MeSH
- spektroskopie infračervená s Fourierovou transformací MeSH
- věkové faktory MeSH
- Check Tag
- lidé MeSH
- novorozenec MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
