Introduction: Solute Carrier (SLC) and ATP-binding cassette (ABC) transporters expressed in the intestine, liver, and kidney determine the absorption, distribution, and excretion of drugs. In addition, most molecular and cellular processes show circadian rhythmicity controlled by circadian clocks that leads to diurnal variations in the pharmacokinetics and pharmacodynamics of many drugs and affects their therapeutic efficacy and toxicity.Area covered: This review provides an overview of the current knowledge on the circadian rhythmicity of drug transporters and the molecular mechanisms of their circadian control. Evidence for coupling drug transporters to circadian oscillators and the plausible candidates conveying circadian clock signals to target drug transporters, particularly transcription factors operating as the output of clock genes, is discussed.Expert opinion: The circadian machinery has been demonstrated to interact with the uptake and efflux of various drug transporters. The evidence supports the concept that diurnal changes that affect drug transporters may influence the pharmacokinetics of the drugs. However, more systematic studies are required to better define the timing of pharmacologically important drug transporter regulation and determine tissue- and sex-dependent differences. Finally, the transfer of knowledge based on the results and conclusions obtained primarily from animal models will require careful validation before it is applied to humans.
- MeSH
- ABC transportéry genetika fyziologie MeSH
- časové faktory MeSH
- cirkadiánní rytmus fyziologie MeSH
- farmakokinetika MeSH
- léčivé přípravky metabolismus MeSH
- lidé MeSH
- sexuální faktory MeSH
- SLC transportéry genetika fyziologie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
- MeSH
- draslík MeSH
- elektroforéza kapilární metody využití MeSH
- finanční podpora výzkumu jako téma MeSH
- hormony kůry nadledvin chemie metabolismus MeSH
- iontový transport fyziologie MeSH
- kolon metabolismus růst a vývoj MeSH
- krysa rodu rattus MeSH
- sodík MeSH
- vysokoúčinná kapalinová chromatografie metody využití MeSH
- zvířata MeSH
- Check Tag
- krysa rodu rattus MeSH
- zvířata MeSH
- Publikační typ
- přehledy MeSH
