We examined insulin sensitivity and secretion, together with the levels of selected glucoregulatory hormones, in 15 female patients with severe hypothyroidism (H) and during subsequent thyroid hormone replacement therapy (HRT) using the euglycaemic hyperinsulinaemic clamp technique. Insulin action, as evaluated by glucose disposal, the insulin sensitivity index, and fasting post-hepatic insulin delivery rate were established. The basal levels of insulin, C-peptide and counter-regulatory hormones were measured in basal condition. In H, glucose disposal (p<0.01), the insulin sensitivity index (p<0.01) and post-hepatic insulin delivery rate (p<0.05) were significantly lower than during HRT. No significant changes in the levels of fasting insulin and C-peptide were observed. The levels of counter-regulatory hormones in patients with H were significantly higher than during HRT (glucagon, p<0.05; epinephrine, p<0.01; cortisol, p<0.05; growth hormone, p<0.05). In H, an inverse correlation between insulin sensitivity and insulin secretion was observed (p<0.05). Cortisol was the most important factor affecting the variability of insulin sensitivity values, regardless of thyroid function (p=0.0012). In conclusion, H altered both insulin sensitivity and the levels of selected counter-regulatory hormones. The situation was restored by HRT, as manifested not only by normalisation of insulin sensitivity, secretion and levels of glucoregulatory hormones, but also by improvement of their relationships.
- MeSH
- adrenalin krev MeSH
- C-peptid krev MeSH
- dospělí MeSH
- financování organizované MeSH
- glukagon krev MeSH
- glykemický clamp MeSH
- hormony štítné žlázy krev terapeutické užití MeSH
- hormony krev sekrece MeSH
- hydrokortison krev MeSH
- hypotyreóza farmakoterapie patofyziologie MeSH
- inzulin krev sekrece MeSH
- inzulinová rezistence MeSH
- krevní glukóza metabolismus MeSH
- lidé MeSH
- lidský růstový hormon krev MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- ženské pohlaví MeSH
- MeSH
- C-peptid krev MeSH
- dospělí MeSH
- finanční podpora výzkumu jako téma MeSH
- glukosa metabolismus MeSH
- hormony krev MeSH
- hypotyreóza diagnóza MeSH
- inzulin farmakologie MeSH
- Langerhansovy ostrůvky sekrece MeSH
- lidé středního věku MeSH
- lidé MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- ženské pohlaví MeSH
- Publikační typ
- kongresy MeSH
- MeSH
- dospělí MeSH
- hormonální substituční terapie MeSH
- hormony štítné žlázy krev terapeutické užití MeSH
- hypotyreóza farmakoterapie komplikace metabolismus MeSH
- inzulin farmakologie MeSH
- krevní glukóza metabolismus MeSH
- Langerhansovy ostrůvky sekrece účinky léků MeSH
- lidé MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- ženské pohlaví MeSH
- Publikační typ
- srovnávací studie MeSH
