BACKGROUND: Obstructive sleep apnea (OSA) is a condition contributing to oxidative stress. The aim of this study was to ascertain if there is any connection between OSA and novel oxidative stress-related markers. Matrix metalloproteinases 2 and 9 (MMP-2, MMP-9), high sensitive C-reactive protein (hsCRP), pregnancy-associated plasma protein-A (PAPP-A), soluble receptors for advanced glycation end-products (sRAGE), zinc (Zn) and copper (Cu) were measured. Further biochemical markers were evaluated. MATERIAL/METHODS: Fifty-one men suspected for OSA indicated for night polygraphy were included. Apnea/hypopnea index (AHI), oxygen desaturation index (ODI), mean blood hemoglobin oxygen saturation (SpO2) and time of blood hemoglobin oxygen saturation below 90% (SpO2 <90%) were measured. Morning venous blood samples were taken. RESULTS: For body mass index (BMI) we found strong positive correlation with levels of Cu, MMP-9, hsCRP and fibrinogen, and negative correlation with sRAGE. Concerning ventilation parameters, we found positive correlation of ODI and SpO2 <90% with markers MMP-9 and hsCRP. sRAGE level correlated with AHI and ODI negatively. SpO2 correlated negatively with Cu, MMP-9, hsCRP and fibrinogen. There was no correlation between ventilation parameters and markers MMP-2, PAPP-A and Zn. Compared to severity of OSA, there was significant difference in levels of hsCRP and Cu between patients with AHI ≤5 and AHI ≥30 independent of BMI. CONCLUSIONS: MMP-9, hsCRP, sRAGE and Cu seem to be strong predictors of oxidative stress in OSA patients. The strong correlation between oxidative stress-related markers and OSA is elucidated by connection of these to BMI, which is probably a primary condition of oxidative stress, but OSA is an additive condition.
- MeSH
- biologické markery metabolismus MeSH
- C-reaktivní protein metabolismus MeSH
- dospělí MeSH
- kyslík metabolismus MeSH
- lidé středního věku MeSH
- lidé MeSH
- matrixová metaloproteinasa 9 metabolismus MeSH
- měď metabolismus MeSH
- obstrukční spánková apnoe enzymologie metabolismus patologie MeSH
- oxidační stres MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Shift work is associated with increased risk of health problems. We chose to test the parameters of wakefulness at shift-working nurses using the Performance Vigilance Task (PVT-192). The visual analogue scale of sleepiness (VAS) and selected sleep history data were included in the investigation. 20 nurses working in a 12-hour rotating shift regimen were included. Exclusion criteria comprised the use of sleep-modulating drugs, the presence of history-based sleep disorders, morbidity. Each of the nurses underwent a total of four PVT tests, before and then after her (day or night) duty. The reaction time (RT) mean value before the day shift was 261.3ms (SD±38.7), after the day shift 260.1ms (SD±33.1), before the night shift 251.3ms (SD±23.5), after the night shift 260.5ms (SD±26.1). There were significant differences in RT before and after the night duty, and between the RT of both evening measurements. The difference in RT before and after duty was significantly greater after night shifts. There was a significant difference between the rate of PVT test errors before the day shift and after the night shift. VAS-based subjective rating of daytime sleepiness was 3.3 (SD±2.2) before and 3.5 (SD±2.8) after the day shift, 3.1 (SD±2.4) before and 5.9 (SD±2.3) after the night shift. There was a significant difference between VAS before and after night shifts, and a significant difference in the VAS difference between the beginning and end of the night shift in comparison with the day shift. Clearly enough, the circadian aspect has a major role to play in the testing.
- MeSH
- arousal MeSH
- chybná zdravotní péče statistika a číselné údaje MeSH
- cirkadiánní rytmus MeSH
- financování organizované MeSH
- kohortové studie MeSH
- lidé MeSH
- noční péče o pacienty pracovní síly MeSH
- personál sesterský nemocniční MeSH
- poruchy cirkadiánního rytmu (spánek) epidemiologie etiologie komplikace MeSH
- poruchy spánku a bdění etiologie komplikace MeSH
- reakční čas MeSH
- vliv směnného provozu na zdraví fyziologie MeSH
- Check Tag
- lidé MeSH
- ženské pohlaví MeSH
- MeSH
- dopravní nehody klasifikace psychologie statistika a číselné údaje MeSH
- finanční podpora výzkumu jako téma MeSH
- lidé MeSH
- poruchy nadměrné spavosti epidemiologie etiologie MeSH
- poruchy spánku a bdění epidemiologie etiologie MeSH
- řízení motorových vozidel psychologie statistika a číselné údaje MeSH
- rizikové faktory MeSH
- spánková deprivace epidemiologie etiologie MeSH
- Check Tag
- lidé MeSH
