- MeSH
- ambulantní monitorování MeSH
- antikoagulancia MeSH
- hypertenze farmakoterapie MeSH
- inhibitory agregace trombocytů farmakologie MeSH
- ischemická cévní mozková příhoda * klasifikace ošetřování terapie MeSH
- konziliární vyšetření a konzultace MeSH
- lidé MeSH
- regulace glykemie MeSH
- stenóza arteria carotis MeSH
- trombolytická terapie MeSH
- urgentní zdravotnické služby MeSH
- Check Tag
- lidé MeSH
The neural substrate subserving magnetoreception and magnetic orientation in mammals is largely unknown. Previous experiments have demonstrated that the processing of magnetic sensory information takes place in the superior colliculus. Here, the effects of magnetic field conditions on neuronal activity in the rodent navigation circuit were assessed by quantifying c-Fos expression. Ansell's mole-rats (Fukomys anselli), a mammalian model to study the mechanisms of magnetic compass orientation, were subjected to natural, periodically changing, and shielded magnetic fields while exploring an unfamiliar circular arena. In the undisturbed local geomagnetic field, the exploration of the novel environment and/or nesting behaviour induced c-Fos expression throughout the head direction system and the entorhinal-hippocampal spatial representation system. This induction was significantly suppressed by exposure to periodically changing and/or shielded magnetic fields; discrete decreases in c-Fos were seen in the dorsal tegmental nucleus, the anterodorsal and the laterodorsal thalamic nuclei, the postsubiculum, the retrosplenial and entorhinal cortices, and the hippocampus. Moreover, in inactive animals, magnetic field intensity manipulation suppressed c-Fos expression in the CA1 and CA3 fields of the hippocampus and the dorsal subiculum, but induced expression in the polymorph layer of the dentate gyrus. These findings suggest that key constituents of the rodent navigation circuit contain populations of neurons responsive to magnetic stimuli. Thus, magnetic information may be integrated with multimodal sensory and motor information into a common spatial representation of allocentric space within this circuit.
- MeSH
- chování zvířat MeSH
- čití, cítění genetika fyziologie MeSH
- colliculus superior metabolismus MeSH
- gyrus dentatus metabolismus MeSH
- hipokampus metabolismus MeSH
- magnetismus MeSH
- mikroftalmičtí podzemní hlodavci genetika metabolismus fyziologie MeSH
- nervové dráhy fyziologie MeSH
- orientace MeSH
- protoonkogenní proteiny c-fos genetika metabolismus MeSH
- somatosenzorické korové centrum metabolismus MeSH
- vnímání prostoru fyziologie MeSH
- zvířata MeSH
- Check Tag
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
