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Author: Coras, Roland

6 hits in Medvik Filters

Article

Outcome of Epilepsy Surgery in MRI-Negative Patients Without Histopathologic Abnormalities in the Resected Tissue

Sanders, Maurits W
Author Sanders, Maurits W ORCID From the Department of Child Neurology (M.W.S, I.V.d.W., F.E.J, K.P.B.), Member of EpiCARE ERN, University Medical Center Utrecht, Utrecht Department of (Neuro)Pathology (E.A.), Amsterdam Neuroscience, Amsterdam UMC, University of Amsterdam Stichting Epilepsie Instellingen Nederland (SEIN) (E.A.), Heemstede, The Netherlands Department of Epileptology (C.H., A.R., R.S.) Department of Neurosurgery (A.G.), University of Bonn Medical Center, Germany Department of Neurosurgery (A.G.), Epilepsy Center Hessen, Philipps University, Marburgy Department of Neuropathology (A.J.B.), University of Bonn Medical Center, Germany Department of Functional Neurology and Epileptology (Sylvain Rheims, H.C.), Hospices Civils de Lyon and University of Lyon Lyon's Neurosciences Research Center (INSERM U1028 / CNRS UMR5292) (Sylvain Rheims, Catenoix Hélène), France UCL Queen Square Institute of Neurology, Department of Clinical and Experimental Epilepsy and National Hospital for Neurology and Neurosurgery (J.S.D., J.D.T.) Developmental Biology and Cancer Programme (T.S.J.), UCL Great Ormond Street Institute of Child Health and the Department of Histopathology, Great Ormond Street Hospital for Children, London UCL- NIHR BRC Great Ormond Street Institute of Child Health (J.H.C.), Great Ormond Street Hospital for Children, Lingfield, United Kingdom Kuopio Epilepsy Center (R.K., T.R.), Kuopio University Hospital and University of Eastern Finland Department of Pathology (R.K., T.R.), Kuopio University Hospital and University of Eastern Finland, Member of EpiCARE ERN, Kuopio, Finland Hospital Sainte-Anne (F.C., B.C.D.), GHU-Paris, France IRCCS NEUROMED (G.D.G., V.E.), Pozzilli (IS), Italy Department of Neurosurgery (V.E.), Sapienza University of Rome, Italy Department of Clinical Neuropathology (Istvan Bodi, M.H.), King's College Hospital NHS Foundation Trust, Academic Neuroscience Center, Denmark Hill, King's College Hospital, London, United Kingdom Department of Epileptology (Krankenhaus Mara) (C.G.B., T.C.), Medical School, Campus Bielefeld-Bethel, Bielefeld University Department of Neuropathology (R.C.) Epilepsy Center (H.M.H.), University Hospital Erlangen, Germany Department of Neurology (P.M., A.K.), Motol Epilepsy Center, Second Medical Faculty, Charles University, Motol University Hospital, Prague, Czech Republic Center for Pediatric Neurology, Neurorehabilitation, and Epileptology (T.P., M.K.), Schoen-Clinic, Vogtareuth, Germany Research Institute "Rehabilitation, Transition, Palliation" (M.K.), PMU Salzburg, Austria Department of Neurology I (T.J.V.O.), Neuromed Campus, Kepler Universitätsklinikum Faculty of Medicine (T.J.V.O., M.A.), Johannes Kepler University Department of Neurosurgery (M.A.), Neuromed Campus, Kepler Universitätsklinikum, Linz, Austria Pediatric Neurosurgery Department (M.C.), Foundation Rothschild Hospital, Paris, France Epilepsy Center (S.N., E.K.), Department of Neurology, Ludwig-Maximilians University, Munich, Germany Epilepsy Centre (A.S.-B.) Department of Neurosurgery (C.F.S.), University Hospital, Freiburg, Germany Department of Neurology (C.O.), Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Turkey Swiss Epilepsy Center and Department of Neurology (K.K.), University Hospital, Zurich, Switzerland Neuroscience Department (Renzo Guerrini, C.B.), Pathology Unit (A.M.B.), and Neurosurgery Department (F.G.), Meyer Children's Hospital IRCCS, Florence, Italy University of Florence (Renzo Guerrini, C.B., F.G.), Florence, Italy Epilepsy Center Frankfurt Rhine-Main (F.R.), Department of Neurology, and LOEWE Center for Personalized Translational Epilepsy Research (CePTER), Goethe University Frankfurt, Frankfurt am Main Department of Neurology (F.R., K.M.), Epilepsy Center Hessen, Philipps University, Marburg, Germany Epilepsy Unit (Rita Garbelli, F.D.), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy Department of Pediatric Neurology (P.K., B.S.), Motol Epilepsy Center, Second Medical Faculty, Charles University, Motol University Hospital, Prague, Czech Republic Department of Pediatric Clinical Epileptology (A.A.A., J.T.), Sleep Disorders and Functional Neurology University Hospitals of Lyon (HCL), Lyon, France Paediatric Epilepsy Unit (A.A.A., V.S.A.-A., J.R.), Child Neurology Department and Neurosurgery Department, Hospital Sant Joan de Déu, Barcelona, Spain Department of Neurology (W.V.P.) Department of Neurosurgery (T.T.), University Hospital Leuven, Belgium Laboratory of Neuropathology (J.P., I.M.L.D.A.), Department of Neurosciences and Mental Health, Department of Neurology, Hospital de Santa Maria (CHULN)Lisbon, Portugal Clinical and Experimental Neurology (N.S., L.D.P.), Bambino Gesu' Children's Hospital, IRCCS, Rome, Italy Center for Rare and Complex Epilepsies (M.F., T.S.), Department of Pediatrics and Adolescent Medicine Department of Neurosurgery (K.R.), Medical University of Vienna, Austria Epilepsy Program (R.T.D., A.G.-N.), Hospital Ruber Internacional, Madrid, Spain Laboratory for Neuropathology (Savo Raicevic), Department of Pathology Department for Epilepsy (A.J.R.), Clinic of Neurology, Clinical Center of Serbia, Belgrade Medical Faculty (A.J.R.), University of Belgrade, Serbia Department of Neurosurgery (O.S.), Academic Center for Epileptology Department of Pathology (J.B.), Maastricht University Medical Center, The Netherlands and University Hospital Erlangen (Ingmar Blumcke), Neuropathology, Erlangen, Germany
Van der Wolf, Iskander
Author Van der Wolf, Iskander ORCID From the Department of Child Neurology (M.W.S, I.V.d.W., F.E.J, K.P.B.), Member of EpiCARE ERN, University Medical Center Utrecht, Utrecht Department of (Neuro)Pathology (E.A.), Amsterdam Neuroscience, Amsterdam UMC, University of Amsterdam Stichting Epilepsie Instellingen Nederland (SEIN) (E.A.), Heemstede, The Netherlands Department of Epileptology (C.H., A.R., R.S.) Department of Neurosurgery (A.G.), University of Bonn Medical Center, Germany Department of Neurosurgery (A.G.), Epilepsy Center Hessen, Philipps University, Marburgy Department of Neuropathology (A.J.B.), University of Bonn Medical Center, Germany Department of Functional Neurology and Epileptology (Sylvain Rheims, H.C.), Hospices Civils de Lyon and University of Lyon Lyon's Neurosciences Research Center (INSERM U1028 / CNRS UMR5292) (Sylvain Rheims, Catenoix Hélène), France UCL Queen Square Institute of Neurology, Department of Clinical and Experimental Epilepsy and National Hospital for Neurology and Neurosurgery (J.S.D., J.D.T.) Developmental Biology and Cancer Programme (T.S.J.), UCL Great Ormond Street Institute of Child Health and the Department of Histopathology, Great Ormond Street Hospital for Children, London UCL- NIHR BRC Great Ormond Street Institute of Child Health (J.H.C.), Great Ormond Street Hospital for Children, Lingfield, United Kingdom Kuopio Epilepsy Center (R.K., T.R.), Kuopio University Hospital and University of Eastern Finland Department of Pathology (R.K., T.R.), Kuopio University Hospital and University of Eastern Finland, Member of EpiCARE ERN, Kuopio, Finland Hospital Sainte-Anne (F.C., B.C.D.), GHU-Paris, France IRCCS NEUROMED (G.D.G., V.E.), Pozzilli (IS), Italy Department of Neurosurgery (V.E.), Sapienza University of Rome, Italy Department of Clinical Neuropathology (Istvan Bodi, M.H.), King's College Hospital NHS Foundation Trust, Academic Neuroscience Center, Denmark Hill, King's College Hospital, London, United Kingdom Department of Epileptology (Krankenhaus Mara) (C.G.B., T.C.), Medical School, Campus Bielefeld-Bethel, Bielefeld University Department of Neuropathology (R.C.) Epilepsy Center (H.M.H.), University Hospital Erlangen, Germany Department of Neurology (P.M., A.K.), Motol Epilepsy Center, Second Medical Faculty, Charles University, Motol University Hospital, Prague, Czech Republic Center for Pediatric Neurology, Neurorehabilitation, and Epileptology (T.P., M.K.), Schoen-Clinic, Vogtareuth, Germany Research Institute "Rehabilitation, Transition, Palliation" (M.K.), PMU Salzburg, Austria Department of Neurology I (T.J.V.O.), Neuromed Campus, Kepler Universitätsklinikum Faculty of Medicine (T.J.V.O., M.A.), Johannes Kepler University Department of Neurosurgery (M.A.), Neuromed Campus, Kepler Universitätsklinikum, Linz, Austria Pediatric Neurosurgery Department (M.C.), Foundation Rothschild Hospital, Paris, France Epilepsy Center (S.N., E.K.), Department of Neurology, Ludwig-Maximilians University, Munich, Germany Epilepsy Centre (A.S.-B.) Department of Neurosurgery (C.F.S.), University Hospital, Freiburg, Germany Department of Neurology (C.O.), Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Turkey Swiss Epilepsy Center and Department of Neurology (K.K.), University Hospital, Zurich, Switzerland Neuroscience Department (Renzo Guerrini, C.B.), Pathology Unit (A.M.B.), and Neurosurgery Department (F.G.), Meyer Children's Hospital IRCCS, Florence, Italy University of Florence (Renzo Guerrini, C.B., F.G.), Florence, Italy Epilepsy Center Frankfurt Rhine-Main (F.R.), Department of Neurology, and LOEWE Center for Personalized Translational Epilepsy Research (CePTER), Goethe University Frankfurt, Frankfurt am Main Department of Neurology (F.R., K.M.), Epilepsy Center Hessen, Philipps University, Marburg, Germany Epilepsy Unit (Rita Garbelli, F.D.), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy Department of Pediatric Neurology (P.K., B.S.), Motol Epilepsy Center, Second Medical Faculty, Charles University, Motol University Hospital, Prague, Czech Republic Department of Pediatric Clinical Epileptology (A.A.A., J.T.), Sleep Disorders and Functional Neurology University Hospitals of Lyon (HCL), Lyon, France Paediatric Epilepsy Unit (A.A.A., V.S.A.-A., J.R.), Child Neurology Department and Neurosurgery Department, Hospital Sant Joan de Déu, Barcelona, Spain Department of Neurology (W.V.P.) Department of Neurosurgery (T.T.), University Hospital Leuven, Belgium Laboratory of Neuropathology (J.P., I.M.L.D.A.), Department of Neurosciences and Mental Health, Department of Neurology, Hospital de Santa Maria (CHULN)Lisbon, Portugal Clinical and Experimental Neurology (N.S., L.D.P.), Bambino Gesu' Children's Hospital, IRCCS, Rome, Italy Center for Rare and Complex Epilepsies (M.F., T.S.), Department of Pediatrics and Adolescent Medicine Department of Neurosurgery (K.R.), Medical University of Vienna, Austria Epilepsy Program (R.T.D., A.G.-N.), Hospital Ruber Internacional, Madrid, Spain Laboratory for Neuropathology (Savo Raicevic), Department of Pathology Department for Epilepsy (A.J.R.), Clinic of Neurology, Clinical Center of Serbia, Belgrade Medical Faculty (A.J.R.), University of Belgrade, Serbia Department of Neurosurgery (O.S.), Academic Center for Epileptology Department of Pathology (J.B.), Maastricht University Medical Center, The Netherlands and University Hospital Erlangen (Ingmar Blumcke), Neuropathology, Erlangen, Germany
Jansen, Floor E
Author Jansen, Floor E ORCID From the Department of Child Neurology (M.W.S, I.V.d.W., F.E.J, K.P.B.), Member of EpiCARE ERN, University Medical Center Utrecht, Utrecht Department of (Neuro)Pathology (E.A.), Amsterdam Neuroscience, Amsterdam UMC, University of Amsterdam Stichting Epilepsie Instellingen Nederland (SEIN) (E.A.), Heemstede, The Netherlands Department of Epileptology (C.H., A.R., R.S.) Department of Neurosurgery (A.G.), University of Bonn Medical Center, Germany Department of Neurosurgery (A.G.), Epilepsy Center Hessen, Philipps University, Marburgy Department of Neuropathology (A.J.B.), University of Bonn Medical Center, Germany Department of Functional Neurology and Epileptology (Sylvain Rheims, H.C.), Hospices Civils de Lyon and University of Lyon Lyon's Neurosciences Research Center (INSERM U1028 / CNRS UMR5292) (Sylvain Rheims, Catenoix Hélène), France UCL Queen Square Institute of Neurology, Department of Clinical and Experimental Epilepsy and National Hospital for Neurology and Neurosurgery (J.S.D., J.D.T.) Developmental Biology and Cancer Programme (T.S.J.), UCL Great Ormond Street Institute of Child Health and the Department of Histopathology, Great Ormond Street Hospital for Children, London UCL- NIHR BRC Great Ormond Street Institute of Child Health (J.H.C.), Great Ormond Street Hospital for Children, Lingfield, United Kingdom Kuopio Epilepsy Center (R.K., T.R.), Kuopio University Hospital and University of Eastern Finland Department of Pathology (R.K., T.R.), Kuopio University Hospital and University of Eastern Finland, Member of EpiCARE ERN, Kuopio, Finland Hospital Sainte-Anne (F.C., B.C.D.), GHU-Paris, France IRCCS NEUROMED (G.D.G., V.E.), Pozzilli (IS), Italy Department of Neurosurgery (V.E.), Sapienza University of Rome, Italy Department of Clinical Neuropathology (Istvan Bodi, M.H.), King's College Hospital NHS Foundation Trust, Academic Neuroscience Center, Denmark Hill, King's College Hospital, London, United Kingdom Department of Epileptology (Krankenhaus Mara) (C.G.B., T.C.), Medical School, Campus Bielefeld-Bethel, Bielefeld University Department of Neuropathology (R.C.) Epilepsy Center (H.M.H.), University Hospital Erlangen, Germany Department of Neurology (P.M., A.K.), Motol Epilepsy Center, Second Medical Faculty, Charles University, Motol University Hospital, Prague, Czech Republic Center for Pediatric Neurology, Neurorehabilitation, and Epileptology (T.P., M.K.), Schoen-Clinic, Vogtareuth, Germany Research Institute "Rehabilitation, Transition, Palliation" (M.K.), PMU Salzburg, Austria Department of Neurology I (T.J.V.O.), Neuromed Campus, Kepler Universitätsklinikum Faculty of Medicine (T.J.V.O., M.A.), Johannes Kepler University Department of Neurosurgery (M.A.), Neuromed Campus, Kepler Universitätsklinikum, Linz, Austria Pediatric Neurosurgery Department (M.C.), Foundation Rothschild Hospital, Paris, France Epilepsy Center (S.N., E.K.), Department of Neurology, Ludwig-Maximilians University, Munich, Germany Epilepsy Centre (A.S.-B.) Department of Neurosurgery (C.F.S.), University Hospital, Freiburg, Germany Department of Neurology (C.O.), Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Turkey Swiss Epilepsy Center and Department of Neurology (K.K.), University Hospital, Zurich, Switzerland Neuroscience Department (Renzo Guerrini, C.B.), Pathology Unit (A.M.B.), and Neurosurgery Department (F.G.), Meyer Children's Hospital IRCCS, Florence, Italy University of Florence (Renzo Guerrini, C.B., F.G.), Florence, Italy Epilepsy Center Frankfurt Rhine-Main (F.R.), Department of Neurology, and LOEWE Center for Personalized Translational Epilepsy Research (CePTER), Goethe University Frankfurt, Frankfurt am Main Department of Neurology (F.R., K.M.), Epilepsy Center Hessen, Philipps University, Marburg, Germany Epilepsy Unit (Rita Garbelli, F.D.), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy Department of Pediatric Neurology (P.K., B.S.), Motol Epilepsy Center, Second Medical Faculty, Charles University, Motol University Hospital, Prague, Czech Republic Department of Pediatric Clinical Epileptology (A.A.A., J.T.), Sleep Disorders and Functional Neurology University Hospitals of Lyon (HCL), Lyon, France Paediatric Epilepsy Unit (A.A.A., V.S.A.-A., J.R.), Child Neurology Department and Neurosurgery Department, Hospital Sant Joan de Déu, Barcelona, Spain Department of Neurology (W.V.P.) Department of Neurosurgery (T.T.), University Hospital Leuven, Belgium Laboratory of Neuropathology (J.P., I.M.L.D.A.), Department of Neurosciences and Mental Health, Department of Neurology, Hospital de Santa Maria (CHULN)Lisbon, Portugal Clinical and Experimental Neurology (N.S., L.D.P.), Bambino Gesu' Children's Hospital, IRCCS, Rome, Italy Center for Rare and Complex Epilepsies (M.F., T.S.), Department of Pediatrics and Adolescent Medicine Department of Neurosurgery (K.R.), Medical University of Vienna, Austria Epilepsy Program (R.T.D., A.G.-N.), Hospital Ruber Internacional, Madrid, Spain Laboratory for Neuropathology (Savo Raicevic), Department of Pathology Department for Epilepsy (A.J.R.), Clinic of Neurology, Clinical Center of Serbia, Belgrade Medical Faculty (A.J.R.), University of Belgrade, Serbia Department of Neurosurgery (O.S.), Academic Center for Epileptology Department of Pathology (J.B.), Maastricht University Medical Center, The Netherlands and University Hospital Erlangen (Ingmar Blumcke), Neuropathology, Erlangen, Germany
Aronica, Eleonora
Author Aronica, Eleonora ORCID From the Department of Child Neurology (M.W.S, I.V.d.W., F.E.J, K.P.B.), Member of EpiCARE ERN, University Medical Center Utrecht, Utrecht Department of (Neuro)Pathology (E.A.), Amsterdam Neuroscience, Amsterdam UMC, University of Amsterdam Stichting Epilepsie Instellingen Nederland (SEIN) (E.A.), Heemstede, The Netherlands Department of Epileptology (C.H., A.R., R.S.) Department of Neurosurgery (A.G.), University of Bonn Medical Center, Germany Department of Neurosurgery (A.G.), Epilepsy Center Hessen, Philipps University, Marburgy Department of Neuropathology (A.J.B.), University of Bonn Medical Center, Germany Department of Functional Neurology and Epileptology (Sylvain Rheims, H.C.), Hospices Civils de Lyon and University of Lyon Lyon's Neurosciences Research Center (INSERM U1028 / CNRS UMR5292) (Sylvain Rheims, Catenoix Hélène), France UCL Queen Square Institute of Neurology, Department of Clinical and Experimental Epilepsy and National Hospital for Neurology and Neurosurgery (J.S.D., J.D.T.) Developmental Biology and Cancer Programme (T.S.J.), UCL Great Ormond Street Institute of Child Health and the Department of Histopathology, Great Ormond Street Hospital for Children, London UCL- NIHR BRC Great Ormond Street Institute of Child Health (J.H.C.), Great Ormond Street Hospital for Children, Lingfield, United Kingdom Kuopio Epilepsy Center (R.K., T.R.), Kuopio University Hospital and University of Eastern Finland Department of Pathology (R.K., T.R.), Kuopio University Hospital and University of Eastern Finland, Member of EpiCARE ERN, Kuopio, Finland Hospital Sainte-Anne (F.C., B.C.D.), GHU-Paris, France IRCCS NEUROMED (G.D.G., V.E.), Pozzilli (IS), Italy Department of Neurosurgery (V.E.), Sapienza University of Rome, Italy Department of Clinical Neuropathology (Istvan Bodi, M.H.), King's College Hospital NHS Foundation Trust, Academic Neuroscience Center, Denmark Hill, King's College Hospital, London, United Kingdom Department of Epileptology (Krankenhaus Mara) (C.G.B., T.C.), Medical School, Campus Bielefeld-Bethel, Bielefeld University Department of Neuropathology (R.C.) Epilepsy Center (H.M.H.), University Hospital Erlangen, Germany Department of Neurology (P.M., A.K.), Motol Epilepsy Center, Second Medical Faculty, Charles University, Motol University Hospital, Prague, Czech Republic Center for Pediatric Neurology, Neurorehabilitation, and Epileptology (T.P., M.K.), Schoen-Clinic, Vogtareuth, Germany Research Institute "Rehabilitation, Transition, Palliation" (M.K.), PMU Salzburg, Austria Department of Neurology I (T.J.V.O.), Neuromed Campus, Kepler Universitätsklinikum Faculty of Medicine (T.J.V.O., M.A.), Johannes Kepler University Department of Neurosurgery (M.A.), Neuromed Campus, Kepler Universitätsklinikum, Linz, Austria Pediatric Neurosurgery Department (M.C.), Foundation Rothschild Hospital, Paris, France Epilepsy Center (S.N., E.K.), Department of Neurology, Ludwig-Maximilians University, Munich, Germany Epilepsy Centre (A.S.-B.) Department of Neurosurgery (C.F.S.), University Hospital, Freiburg, Germany Department of Neurology (C.O.), Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Turkey Swiss Epilepsy Center and Department of Neurology (K.K.), University Hospital, Zurich, Switzerland Neuroscience Department (Renzo Guerrini, C.B.), Pathology Unit (A.M.B.), and Neurosurgery Department (F.G.), Meyer Children's Hospital IRCCS, Florence, Italy University of Florence (Renzo Guerrini, C.B., F.G.), Florence, Italy Epilepsy Center Frankfurt Rhine-Main (F.R.), Department of Neurology, and LOEWE Center for Personalized Translational Epilepsy Research (CePTER), Goethe University Frankfurt, Frankfurt am Main Department of Neurology (F.R., K.M.), Epilepsy Center Hessen, Philipps University, Marburg, Germany Epilepsy Unit (Rita Garbelli, F.D.), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy Department of Pediatric Neurology (P.K., B.S.), Motol Epilepsy Center, Second Medical Faculty, Charles University, Motol University Hospital, Prague, Czech Republic Department of Pediatric Clinical Epileptology (A.A.A., J.T.), Sleep Disorders and Functional Neurology University Hospitals of Lyon (HCL), Lyon, France Paediatric Epilepsy Unit (A.A.A., V.S.A.-A., J.R.), Child Neurology Department and Neurosurgery Department, Hospital Sant Joan de Déu, Barcelona, Spain Department of Neurology (W.V.P.) Department of Neurosurgery (T.T.), University Hospital Leuven, Belgium Laboratory of Neuropathology (J.P., I.M.L.D.A.), Department of Neurosciences and Mental Health, Department of Neurology, Hospital de Santa Maria (CHULN)Lisbon, Portugal Clinical and Experimental Neurology (N.S., L.D.P.), Bambino Gesu' Children's Hospital, IRCCS, Rome, Italy Center for Rare and Complex Epilepsies (M.F., T.S.), Department of Pediatrics and Adolescent Medicine Department of Neurosurgery (K.R.), Medical University of Vienna, Austria Epilepsy Program (R.T.D., A.G.-N.), Hospital Ruber Internacional, Madrid, Spain Laboratory for Neuropathology (Savo Raicevic), Department of Pathology Department for Epilepsy (A.J.R.), Clinic of Neurology, Clinical Center of Serbia, Belgrade Medical Faculty (A.J.R.), University of Belgrade, Serbia Department of Neurosurgery (O.S.), Academic Center for Epileptology Department of Pathology (J.B.), Maastricht University Medical Center, The Netherlands and University Hospital Erlangen (Ingmar Blumcke), Neuropathology, Erlangen, Germany
Helmstaedter, Christoph
Author Helmstaedter, Christoph ORCID From the Department of Child Neurology (M.W.S, I.V.d.W., F.E.J, K.P.B.), Member of EpiCARE ERN, University Medical Center Utrecht, Utrecht Department of (Neuro)Pathology (E.A.), Amsterdam Neuroscience, Amsterdam UMC, University of Amsterdam Stichting Epilepsie Instellingen Nederland (SEIN) (E.A.), Heemstede, The Netherlands Department of Epileptology (C.H., A.R., R.S.) Department of Neurosurgery (A.G.), University of Bonn Medical Center, Germany Department of Neurosurgery (A.G.), Epilepsy Center Hessen, Philipps University, Marburgy Department of Neuropathology (A.J.B.), University of Bonn Medical Center, Germany Department of Functional Neurology and Epileptology (Sylvain Rheims, H.C.), Hospices Civils de Lyon and University of Lyon Lyon's Neurosciences Research Center (INSERM U1028 / CNRS UMR5292) (Sylvain Rheims, Catenoix Hélène), France UCL Queen Square Institute of Neurology, Department of Clinical and Experimental Epilepsy and National Hospital for Neurology and Neurosurgery (J.S.D., J.D.T.) Developmental Biology and Cancer Programme (T.S.J.), UCL Great Ormond Street Institute of Child Health and the Department of Histopathology, Great Ormond Street Hospital for Children, London UCL- NIHR BRC Great Ormond Street Institute of Child Health (J.H.C.), Great Ormond Street Hospital for Children, Lingfield, United Kingdom Kuopio Epilepsy Center (R.K., T.R.), Kuopio University Hospital and University of Eastern Finland Department of Pathology (R.K., T.R.), Kuopio University Hospital and University of Eastern Finland, Member of EpiCARE ERN, Kuopio, Finland Hospital Sainte-Anne (F.C., B.C.D.), GHU-Paris, France IRCCS NEUROMED (G.D.G., V.E.), Pozzilli (IS), Italy Department of Neurosurgery (V.E.), Sapienza University of Rome, Italy Department of Clinical Neuropathology (Istvan Bodi, M.H.), King's College Hospital NHS Foundation Trust, Academic Neuroscience Center, Denmark Hill, King's College Hospital, London, United Kingdom Department of Epileptology (Krankenhaus Mara) (C.G.B., T.C.), Medical School, Campus Bielefeld-Bethel, Bielefeld University Department of Neuropathology (R.C.) Epilepsy Center (H.M.H.), University Hospital Erlangen, Germany Department of Neurology (P.M., A.K.), Motol Epilepsy Center, Second Medical Faculty, Charles University, Motol University Hospital, Prague, Czech Republic Center for Pediatric Neurology, Neurorehabilitation, and Epileptology (T.P., M.K.), Schoen-Clinic, Vogtareuth, Germany Research Institute "Rehabilitation, Transition, Palliation" (M.K.), PMU Salzburg, Austria Department of Neurology I (T.J.V.O.), Neuromed Campus, Kepler Universitätsklinikum Faculty of Medicine (T.J.V.O., M.A.), Johannes Kepler University Department of Neurosurgery (M.A.), Neuromed Campus, Kepler Universitätsklinikum, Linz, Austria Pediatric Neurosurgery Department (M.C.), Foundation Rothschild Hospital, Paris, France Epilepsy Center (S.N., E.K.), Department of Neurology, Ludwig-Maximilians University, Munich, Germany Epilepsy Centre (A.S.-B.) Department of Neurosurgery (C.F.S.), University Hospital, Freiburg, Germany Department of Neurology (C.O.), Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Turkey Swiss Epilepsy Center and Department of Neurology (K.K.), University Hospital, Zurich, Switzerland Neuroscience Department (Renzo Guerrini, C.B.), Pathology Unit (A.M.B.), and Neurosurgery Department (F.G.), Meyer Children's Hospital IRCCS, Florence, Italy University of Florence (Renzo Guerrini, C.B., F.G.), Florence, Italy Epilepsy Center Frankfurt Rhine-Main (F.R.), Department of Neurology, and LOEWE Center for Personalized Translational Epilepsy Research (CePTER), Goethe University Frankfurt, Frankfurt am Main Department of Neurology (F.R., K.M.), Epilepsy Center Hessen, Philipps University, Marburg, Germany Epilepsy Unit (Rita Garbelli, F.D.), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy Department of Pediatric Neurology (P.K., B.S.), Motol Epilepsy Center, Second Medical Faculty, Charles University, Motol University Hospital, Prague, Czech Republic Department of Pediatric Clinical Epileptology (A.A.A., J.T.), Sleep Disorders and Functional Neurology University Hospitals of Lyon (HCL), Lyon, France Paediatric Epilepsy Unit (A.A.A., V.S.A.-A., J.R.), Child Neurology Department and Neurosurgery Department, Hospital Sant Joan de Déu, Barcelona, Spain Department of Neurology (W.V.P.) Department of Neurosurgery (T.T.), University Hospital Leuven, Belgium Laboratory of Neuropathology (J.P., I.M.L.D.A.), Department of Neurosciences and Mental Health, Department of Neurology, Hospital de Santa Maria (CHULN)Lisbon, Portugal Clinical and Experimental Neurology (N.S., L.D.P.), Bambino Gesu' Children's Hospital, IRCCS, Rome, Italy Center for Rare and Complex Epilepsies (M.F., T.S.), Department of Pediatrics and Adolescent Medicine Department of Neurosurgery (K.R.), Medical University of Vienna, Austria Epilepsy Program (R.T.D., A.G.-N.), Hospital Ruber Internacional, Madrid, Spain Laboratory for Neuropathology (Savo Raicevic), Department of Pathology Department for Epilepsy (A.J.R.), Clinic of Neurology, Clinical Center of Serbia, Belgrade Medical Faculty (A.J.R.), University of Belgrade, Serbia Department of Neurosurgery (O.S.), Academic Center for Epileptology Department of Pathology (J.B.), Maastricht University Medical Center, The Netherlands and University Hospital Erlangen (Ingmar Blumcke), Neuropathology, Erlangen, Germany
Racz, Attila
Author Racz, Attila ORCID From the Department of Child Neurology (M.W.S, I.V.d.W., F.E.J, K.P.B.), Member of EpiCARE ERN, University Medical Center Utrecht, Utrecht Department of (Neuro)Pathology (E.A.), Amsterdam Neuroscience, Amsterdam UMC, University of Amsterdam Stichting Epilepsie Instellingen Nederland (SEIN) (E.A.), Heemstede, The Netherlands Department of Epileptology (C.H., A.R., R.S.) Department of Neurosurgery (A.G.), University of Bonn Medical Center, Germany Department of Neurosurgery (A.G.), Epilepsy Center Hessen, Philipps University, Marburgy Department of Neuropathology (A.J.B.), University of Bonn Medical Center, Germany Department of Functional Neurology and Epileptology (Sylvain Rheims, H.C.), Hospices Civils de Lyon and University of Lyon Lyon's Neurosciences Research Center (INSERM U1028 / CNRS UMR5292) (Sylvain Rheims, Catenoix Hélène), France UCL Queen Square Institute of Neurology, Department of Clinical and Experimental Epilepsy and National Hospital for Neurology and Neurosurgery (J.S.D., J.D.T.) Developmental Biology and Cancer Programme (T.S.J.), UCL Great Ormond Street Institute of Child Health and the Department of Histopathology, Great Ormond Street Hospital for Children, London UCL- NIHR BRC Great Ormond Street Institute of Child Health (J.H.C.), Great Ormond Street Hospital for Children, Lingfield, United Kingdom Kuopio Epilepsy Center (R.K., T.R.), Kuopio University Hospital and University of Eastern Finland Department of Pathology (R.K., T.R.), Kuopio University Hospital and University of Eastern Finland, Member of EpiCARE ERN, Kuopio, Finland Hospital Sainte-Anne (F.C., B.C.D.), GHU-Paris, France IRCCS NEUROMED (G.D.G., V.E.), Pozzilli (IS), Italy Department of Neurosurgery (V.E.), Sapienza University of Rome, Italy Department of Clinical Neuropathology (Istvan Bodi, M.H.), King's College Hospital NHS Foundation Trust, Academic Neuroscience Center, Denmark Hill, King's College Hospital, London, United Kingdom Department of Epileptology (Krankenhaus Mara) (C.G.B., T.C.), Medical School, Campus Bielefeld-Bethel, Bielefeld University Department of Neuropathology (R.C.) Epilepsy Center (H.M.H.), University Hospital Erlangen, Germany Department of Neurology (P.M., A.K.), Motol Epilepsy Center, Second Medical Faculty, Charles University, Motol University Hospital, Prague, Czech Republic Center for Pediatric Neurology, Neurorehabilitation, and Epileptology (T.P., M.K.), Schoen-Clinic, Vogtareuth, Germany Research Institute "Rehabilitation, Transition, Palliation" (M.K.), PMU Salzburg, Austria Department of Neurology I (T.J.V.O.), Neuromed Campus, Kepler Universitätsklinikum Faculty of Medicine (T.J.V.O., M.A.), Johannes Kepler University Department of Neurosurgery (M.A.), Neuromed Campus, Kepler Universitätsklinikum, Linz, Austria Pediatric Neurosurgery Department (M.C.), Foundation Rothschild Hospital, Paris, France Epilepsy Center (S.N., E.K.), Department of Neurology, Ludwig-Maximilians University, Munich, Germany Epilepsy Centre (A.S.-B.) Department of Neurosurgery (C.F.S.), University Hospital, Freiburg, Germany Department of Neurology (C.O.), Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Turkey Swiss Epilepsy Center and Department of Neurology (K.K.), University Hospital, Zurich, Switzerland Neuroscience Department (Renzo Guerrini, C.B.), Pathology Unit (A.M.B.), and Neurosurgery Department (F.G.), Meyer Children's Hospital IRCCS, Florence, Italy University of Florence (Renzo Guerrini, C.B., F.G.), Florence, Italy Epilepsy Center Frankfurt Rhine-Main (F.R.), Department of Neurology, and LOEWE Center for Personalized Translational Epilepsy Research (CePTER), Goethe University Frankfurt, Frankfurt am Main Department of Neurology (F.R., K.M.), Epilepsy Center Hessen, Philipps University, Marburg, Germany Epilepsy Unit (Rita Garbelli, F.D.), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy Department of Pediatric Neurology (P.K., B.S.), Motol Epilepsy Center, Second Medical Faculty, Charles University, Motol University Hospital, Prague, Czech Republic Department of Pediatric Clinical Epileptology (A.A.A., J.T.), Sleep Disorders and Functional Neurology University Hospitals of Lyon (HCL), Lyon, France Paediatric Epilepsy Unit (A.A.A., V.S.A.-A., J.R.), Child Neurology Department and Neurosurgery Department, Hospital Sant Joan de Déu, Barcelona, Spain Department of Neurology (W.V.P.) Department of Neurosurgery (T.T.), University Hospital Leuven, Belgium Laboratory of Neuropathology (J.P., I.M.L.D.A.), Department of Neurosciences and Mental Health, Department of Neurology, Hospital de Santa Maria (CHULN)Lisbon, Portugal Clinical and Experimental Neurology (N.S., L.D.P.), Bambino Gesu' Children's Hospital, IRCCS, Rome, Italy Center for Rare and Complex Epilepsies (M.F., T.S.), Department of Pediatrics and Adolescent Medicine Department of Neurosurgery (K.R.), Medical University of Vienna, Austria Epilepsy Program (R.T.D., A.G.-N.), Hospital Ruber Internacional, Madrid, Spain Laboratory for Neuropathology (Savo Raicevic), Department of Pathology Department for Epilepsy (A.J.R.), Clinic of Neurology, Clinical Center of Serbia, Belgrade Medical Faculty (A.J.R.), University of Belgrade, Serbia Department of Neurosurgery (O.S.), Academic Center for Epileptology Department of Pathology (J.B.), Maastricht University Medical Center, The Netherlands and University Hospital Erlangen (Ingmar Blumcke), Neuropathology, Erlangen, Germany
Surges, Rainer
Author Surges, Rainer ORCID From the Department of Child Neurology (M.W.S, I.V.d.W., F.E.J, K.P.B.), Member of EpiCARE ERN, University Medical Center Utrecht, Utrecht Department of (Neuro)Pathology (E.A.), Amsterdam Neuroscience, Amsterdam UMC, University of Amsterdam Stichting Epilepsie Instellingen Nederland (SEIN) (E.A.), Heemstede, The Netherlands Department of Epileptology (C.H., A.R., R.S.) Department of Neurosurgery (A.G.), University of Bonn Medical Center, Germany Department of Neurosurgery (A.G.), Epilepsy Center Hessen, Philipps University, Marburgy Department of Neuropathology (A.J.B.), University of Bonn Medical Center, Germany Department of Functional Neurology and Epileptology (Sylvain Rheims, H.C.), Hospices Civils de Lyon and University of Lyon Lyon's Neurosciences Research Center (INSERM U1028 / CNRS UMR5292) (Sylvain Rheims, Catenoix Hélène), France UCL Queen Square Institute of Neurology, Department of Clinical and Experimental Epilepsy and National Hospital for Neurology and Neurosurgery (J.S.D., J.D.T.) Developmental Biology and Cancer Programme (T.S.J.), UCL Great Ormond Street Institute of Child Health and the Department of Histopathology, Great Ormond Street Hospital for Children, London UCL- NIHR BRC Great Ormond Street Institute of Child Health (J.H.C.), Great Ormond Street Hospital for Children, Lingfield, United Kingdom Kuopio Epilepsy Center (R.K., T.R.), Kuopio University Hospital and University of Eastern Finland Department of Pathology (R.K., T.R.), Kuopio University Hospital and University of Eastern Finland, Member of EpiCARE ERN, Kuopio, Finland Hospital Sainte-Anne (F.C., B.C.D.), GHU-Paris, France IRCCS NEUROMED (G.D.G., V.E.), Pozzilli (IS), Italy Department of Neurosurgery (V.E.), Sapienza University of Rome, Italy Department of Clinical Neuropathology (Istvan Bodi, M.H.), King's College Hospital NHS Foundation Trust, Academic Neuroscience Center, Denmark Hill, King's College Hospital, London, United Kingdom Department of Epileptology (Krankenhaus Mara) (C.G.B., T.C.), Medical School, Campus Bielefeld-Bethel, Bielefeld University Department of Neuropathology (R.C.) Epilepsy Center (H.M.H.), University Hospital Erlangen, Germany Department of Neurology (P.M., A.K.), Motol Epilepsy Center, Second Medical Faculty, Charles University, Motol University Hospital, Prague, Czech Republic Center for Pediatric Neurology, Neurorehabilitation, and Epileptology (T.P., M.K.), Schoen-Clinic, Vogtareuth, Germany Research Institute "Rehabilitation, Transition, Palliation" (M.K.), PMU Salzburg, Austria Department of Neurology I (T.J.V.O.), Neuromed Campus, Kepler Universitätsklinikum Faculty of Medicine (T.J.V.O., M.A.), Johannes Kepler University Department of Neurosurgery (M.A.), Neuromed Campus, Kepler Universitätsklinikum, Linz, Austria Pediatric Neurosurgery Department (M.C.), Foundation Rothschild Hospital, Paris, France Epilepsy Center (S.N., E.K.), Department of Neurology, Ludwig-Maximilians University, Munich, Germany Epilepsy Centre (A.S.-B.) Department of Neurosurgery (C.F.S.), University Hospital, Freiburg, Germany Department of Neurology (C.O.), Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Turkey Swiss Epilepsy Center and Department of Neurology (K.K.), University Hospital, Zurich, Switzerland Neuroscience Department (Renzo Guerrini, C.B.), Pathology Unit (A.M.B.), and Neurosurgery Department (F.G.), Meyer Children's Hospital IRCCS, Florence, Italy University of Florence (Renzo Guerrini, C.B., F.G.), Florence, Italy Epilepsy Center Frankfurt Rhine-Main (F.R.), Department of Neurology, and LOEWE Center for Personalized Translational Epilepsy Research (CePTER), Goethe University Frankfurt, Frankfurt am Main Department of Neurology (F.R., K.M.), Epilepsy Center Hessen, Philipps University, Marburg, Germany Epilepsy Unit (Rita Garbelli, F.D.), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy Department of Pediatric Neurology (P.K., B.S.), Motol Epilepsy Center, Second Medical Faculty, Charles University, Motol University Hospital, Prague, Czech Republic Department of Pediatric Clinical Epileptology (A.A.A., J.T.), Sleep Disorders and Functional Neurology University Hospitals of Lyon (HCL), Lyon, France Paediatric Epilepsy Unit (A.A.A., V.S.A.-A., J.R.), Child Neurology Department and Neurosurgery Department, Hospital Sant Joan de Déu, Barcelona, Spain Department of Neurology (W.V.P.) Department of Neurosurgery (T.T.), University Hospital Leuven, Belgium Laboratory of Neuropathology (J.P., I.M.L.D.A.), Department of Neurosciences and Mental Health, Department of Neurology, Hospital de Santa Maria (CHULN)Lisbon, Portugal Clinical and Experimental Neurology (N.S., L.D.P.), Bambino Gesu' Children's Hospital, IRCCS, Rome, Italy Center for Rare and Complex Epilepsies (M.F., T.S.), Department of Pediatrics and Adolescent Medicine Department of Neurosurgery (K.R.), Medical University of Vienna, Austria Epilepsy Program (R.T.D., A.G.-N.), Hospital Ruber Internacional, Madrid, Spain Laboratory for Neuropathology (Savo Raicevic), Department of Pathology Department for Epilepsy (A.J.R.), Clinic of Neurology, Clinical Center of Serbia, Belgrade Medical Faculty (A.J.R.), University of Belgrade, Serbia Department of Neurosurgery (O.S.), Academic Center for Epileptology Department of Pathology (J.B.), Maastricht University Medical Center, The Netherlands and University Hospital Erlangen (Ingmar Blumcke), Neuropathology, Erlangen, Germany
Grote, Alexander
Author Grote, Alexander ORCID From the Department of Child Neurology (M.W.S, I.V.d.W., F.E.J, K.P.B.), Member of EpiCARE ERN, University Medical Center Utrecht, Utrecht Department of (Neuro)Pathology (E.A.), Amsterdam Neuroscience, Amsterdam UMC, University of Amsterdam Stichting Epilepsie Instellingen Nederland (SEIN) (E.A.), Heemstede, The Netherlands Department of Epileptology (C.H., A.R., R.S.) Department of Neurosurgery (A.G.), University of Bonn Medical Center, Germany Department of Neurosurgery (A.G.), Epilepsy Center Hessen, Philipps University, Marburgy Department of Neuropathology (A.J.B.), University of Bonn Medical Center, Germany Department of Functional Neurology and Epileptology (Sylvain Rheims, H.C.), Hospices Civils de Lyon and University of Lyon Lyon's Neurosciences Research Center (INSERM U1028 / CNRS UMR5292) (Sylvain Rheims, Catenoix Hélène), France UCL Queen Square Institute of Neurology, Department of Clinical and Experimental Epilepsy and National Hospital for Neurology and Neurosurgery (J.S.D., J.D.T.) Developmental Biology and Cancer Programme (T.S.J.), UCL Great Ormond Street Institute of Child Health and the Department of Histopathology, Great Ormond Street Hospital for Children, London UCL- NIHR BRC Great Ormond Street Institute of Child Health (J.H.C.), Great Ormond Street Hospital for Children, Lingfield, United Kingdom Kuopio Epilepsy Center (R.K., T.R.), Kuopio University Hospital and University of Eastern Finland Department of Pathology (R.K., T.R.), Kuopio University Hospital and University of Eastern Finland, Member of EpiCARE ERN, Kuopio, Finland Hospital Sainte-Anne (F.C., B.C.D.), GHU-Paris, France IRCCS NEUROMED (G.D.G., V.E.), Pozzilli (IS), Italy Department of Neurosurgery (V.E.), Sapienza University of Rome, Italy Department of Clinical Neuropathology (Istvan Bodi, M.H.), King's College Hospital NHS Foundation Trust, Academic Neuroscience Center, Denmark Hill, King's College Hospital, London, United Kingdom Department of Epileptology (Krankenhaus Mara) (C.G.B., T.C.), Medical School, Campus Bielefeld-Bethel, Bielefeld University Department of Neuropathology (R.C.) Epilepsy Center (H.M.H.), University Hospital Erlangen, Germany Department of Neurology (P.M., A.K.), Motol Epilepsy Center, Second Medical Faculty, Charles University, Motol University Hospital, Prague, Czech Republic Center for Pediatric Neurology, Neurorehabilitation, and Epileptology (T.P., M.K.), Schoen-Clinic, Vogtareuth, Germany Research Institute "Rehabilitation, Transition, Palliation" (M.K.), PMU Salzburg, Austria Department of Neurology I (T.J.V.O.), Neuromed Campus, Kepler Universitätsklinikum Faculty of Medicine (T.J.V.O., M.A.), Johannes Kepler University Department of Neurosurgery (M.A.), Neuromed Campus, Kepler Universitätsklinikum, Linz, Austria Pediatric Neurosurgery Department (M.C.), Foundation Rothschild Hospital, Paris, France Epilepsy Center (S.N., E.K.), Department of Neurology, Ludwig-Maximilians University, Munich, Germany Epilepsy Centre (A.S.-B.) Department of Neurosurgery (C.F.S.), University Hospital, Freiburg, Germany Department of Neurology (C.O.), Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Turkey Swiss Epilepsy Center and Department of Neurology (K.K.), University Hospital, Zurich, Switzerland Neuroscience Department (Renzo Guerrini, C.B.), Pathology Unit (A.M.B.), and Neurosurgery Department (F.G.), Meyer Children's Hospital IRCCS, Florence, Italy University of Florence (Renzo Guerrini, C.B., F.G.), Florence, Italy Epilepsy Center Frankfurt Rhine-Main (F.R.), Department of Neurology, and LOEWE Center for Personalized Translational Epilepsy Research (CePTER), Goethe University Frankfurt, Frankfurt am Main Department of Neurology (F.R., K.M.), Epilepsy Center Hessen, Philipps University, Marburg, Germany Epilepsy Unit (Rita Garbelli, F.D.), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy Department of Pediatric Neurology (P.K., B.S.), Motol Epilepsy Center, Second Medical Faculty, Charles University, Motol University Hospital, Prague, Czech Republic Department of Pediatric Clinical Epileptology (A.A.A., J.T.), Sleep Disorders and Functional Neurology University Hospitals of Lyon (HCL), Lyon, France Paediatric Epilepsy Unit (A.A.A., V.S.A.-A., J.R.), Child Neurology Department and Neurosurgery Department, Hospital Sant Joan de Déu, Barcelona, Spain Department of Neurology (W.V.P.) Department of Neurosurgery (T.T.), University Hospital Leuven, Belgium Laboratory of Neuropathology (J.P., I.M.L.D.A.), Department of Neurosciences and Mental Health, Department of Neurology, Hospital de Santa Maria (CHULN)Lisbon, Portugal Clinical and Experimental Neurology (N.S., L.D.P.), Bambino Gesu' Children's Hospital, IRCCS, Rome, Italy Center for Rare and Complex Epilepsies (M.F., T.S.), Department of Pediatrics and Adolescent Medicine Department of Neurosurgery (K.R.), Medical University of Vienna, Austria Epilepsy Program (R.T.D., A.G.-N.), Hospital Ruber Internacional, Madrid, Spain Laboratory for Neuropathology (Savo Raicevic), Department of Pathology Department for Epilepsy (A.J.R.), Clinic of Neurology, Clinical Center of Serbia, Belgrade Medical Faculty (A.J.R.), University of Belgrade, Serbia Department of Neurosurgery (O.S.), Academic Center for Epileptology Department of Pathology (J.B.), Maastricht University Medical Center, The Netherlands and University Hospital Erlangen (Ingmar Blumcke), Neuropathology, Erlangen, Germany
Becker, Albert J
Author Becker, Albert J ORCID From the Department of Child Neurology (M.W.S, I.V.d.W., F.E.J, K.P.B.), Member of EpiCARE ERN, University Medical Center Utrecht, Utrecht Department of (Neuro)Pathology (E.A.), Amsterdam Neuroscience, Amsterdam UMC, University of Amsterdam Stichting Epilepsie Instellingen Nederland (SEIN) (E.A.), Heemstede, The Netherlands Department of Epileptology (C.H., A.R., R.S.) Department of Neurosurgery (A.G.), University of Bonn Medical Center, Germany Department of Neurosurgery (A.G.), Epilepsy Center Hessen, Philipps University, Marburgy Department of Neuropathology (A.J.B.), University of Bonn Medical Center, Germany Department of Functional Neurology and Epileptology (Sylvain Rheims, H.C.), Hospices Civils de Lyon and University of Lyon Lyon's Neurosciences Research Center (INSERM U1028 / CNRS UMR5292) (Sylvain Rheims, Catenoix Hélène), France UCL Queen Square Institute of Neurology, Department of Clinical and Experimental Epilepsy and National Hospital for Neurology and Neurosurgery (J.S.D., J.D.T.) Developmental Biology and Cancer Programme (T.S.J.), UCL Great Ormond Street Institute of Child Health and the Department of Histopathology, Great Ormond Street Hospital for Children, London UCL- NIHR BRC Great Ormond Street Institute of Child Health (J.H.C.), Great Ormond Street Hospital for Children, Lingfield, United Kingdom Kuopio Epilepsy Center (R.K., T.R.), Kuopio University Hospital and University of Eastern Finland Department of Pathology (R.K., T.R.), Kuopio University Hospital and University of Eastern Finland, Member of EpiCARE ERN, Kuopio, Finland Hospital Sainte-Anne (F.C., B.C.D.), GHU-Paris, France IRCCS NEUROMED (G.D.G., V.E.), Pozzilli (IS), Italy Department of Neurosurgery (V.E.), Sapienza University of Rome, Italy Department of Clinical Neuropathology (Istvan Bodi, M.H.), King's College Hospital NHS Foundation Trust, Academic Neuroscience Center, Denmark Hill, King's College Hospital, London, United Kingdom Department of Epileptology (Krankenhaus Mara) (C.G.B., T.C.), Medical School, Campus Bielefeld-Bethel, Bielefeld University Department of Neuropathology (R.C.) Epilepsy Center (H.M.H.), University Hospital Erlangen, Germany Department of Neurology (P.M., A.K.), Motol Epilepsy Center, Second Medical Faculty, Charles University, Motol University Hospital, Prague, Czech Republic Center for Pediatric Neurology, Neurorehabilitation, and Epileptology (T.P., M.K.), Schoen-Clinic, Vogtareuth, Germany Research Institute "Rehabilitation, Transition, Palliation" (M.K.), PMU Salzburg, Austria Department of Neurology I (T.J.V.O.), Neuromed Campus, Kepler Universitätsklinikum Faculty of Medicine (T.J.V.O., M.A.), Johannes Kepler University Department of Neurosurgery (M.A.), Neuromed Campus, Kepler Universitätsklinikum, Linz, Austria Pediatric Neurosurgery Department (M.C.), Foundation Rothschild Hospital, Paris, France Epilepsy Center (S.N., E.K.), Department of Neurology, Ludwig-Maximilians University, Munich, Germany Epilepsy Centre (A.S.-B.) Department of Neurosurgery (C.F.S.), University Hospital, Freiburg, Germany Department of Neurology (C.O.), Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Turkey Swiss Epilepsy Center and Department of Neurology (K.K.), University Hospital, Zurich, Switzerland Neuroscience Department (Renzo Guerrini, C.B.), Pathology Unit (A.M.B.), and Neurosurgery Department (F.G.), Meyer Children's Hospital IRCCS, Florence, Italy University of Florence (Renzo Guerrini, C.B., F.G.), Florence, Italy Epilepsy Center Frankfurt Rhine-Main (F.R.), Department of Neurology, and LOEWE Center for Personalized Translational Epilepsy Research (CePTER), Goethe University Frankfurt, Frankfurt am Main Department of Neurology (F.R., K.M.), Epilepsy Center Hessen, Philipps University, Marburg, Germany Epilepsy Unit (Rita Garbelli, F.D.), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy Department of Pediatric Neurology (P.K., B.S.), Motol Epilepsy Center, Second Medical Faculty, Charles University, Motol University Hospital, Prague, Czech Republic Department of Pediatric Clinical Epileptology (A.A.A., J.T.), Sleep Disorders and Functional Neurology University Hospitals of Lyon (HCL), Lyon, France Paediatric Epilepsy Unit (A.A.A., V.S.A.-A., J.R.), Child Neurology Department and Neurosurgery Department, Hospital Sant Joan de Déu, Barcelona, Spain Department of Neurology (W.V.P.) Department of Neurosurgery (T.T.), University Hospital Leuven, Belgium Laboratory of Neuropathology (J.P., I.M.L.D.A.), Department of Neurosciences and Mental Health, Department of Neurology, Hospital de Santa Maria (CHULN)Lisbon, Portugal Clinical and Experimental Neurology (N.S., L.D.P.), Bambino Gesu' Children's Hospital, IRCCS, Rome, Italy Center for Rare and Complex Epilepsies (M.F., T.S.), Department of Pediatrics and Adolescent Medicine Department of Neurosurgery (K.R.), Medical University of Vienna, Austria Epilepsy Program (R.T.D., A.G.-N.), Hospital Ruber Internacional, Madrid, Spain Laboratory for Neuropathology (Savo Raicevic), Department of Pathology Department for Epilepsy (A.J.R.), Clinic of Neurology, Clinical Center of Serbia, Belgrade Medical Faculty (A.J.R.), University of Belgrade, Serbia Department of Neurosurgery (O.S.), Academic Center for Epileptology Department of Pathology (J.B.), Maastricht University Medical Center, The Netherlands and University Hospital Erlangen (Ingmar Blumcke), Neuropathology, Erlangen, Germany
Rheims, Sylvain
Author Rheims, Sylvain ORCID From the Department of Child Neurology (M.W.S, I.V.d.W., F.E.J, K.P.B.), Member of EpiCARE ERN, University Medical Center Utrecht, Utrecht Department of (Neuro)Pathology (E.A.), Amsterdam Neuroscience, Amsterdam UMC, University of Amsterdam Stichting Epilepsie Instellingen Nederland (SEIN) (E.A.), Heemstede, The Netherlands Department of Epileptology (C.H., A.R., R.S.) Department of Neurosurgery (A.G.), University of Bonn Medical Center, Germany Department of Neurosurgery (A.G.), Epilepsy Center Hessen, Philipps University, Marburgy Department of Neuropathology (A.J.B.), University of Bonn Medical Center, Germany Department of Functional Neurology and Epileptology (Sylvain Rheims, H.C.), Hospices Civils de Lyon and University of Lyon Lyon's Neurosciences Research Center (INSERM U1028 / CNRS UMR5292) (Sylvain Rheims, Catenoix Hélène), France UCL Queen Square Institute of Neurology, Department of Clinical and Experimental Epilepsy and National Hospital for Neurology and Neurosurgery (J.S.D., J.D.T.) Developmental Biology and Cancer Programme (T.S.J.), UCL Great Ormond Street Institute of Child Health and the Department of Histopathology, Great Ormond Street Hospital for Children, London UCL- NIHR BRC Great Ormond Street Institute of Child Health (J.H.C.), Great Ormond Street Hospital for Children, Lingfield, United Kingdom Kuopio Epilepsy Center (R.K., T.R.), Kuopio University Hospital and University of Eastern Finland Department of Pathology (R.K., T.R.), Kuopio University Hospital and University of Eastern Finland, Member of EpiCARE ERN, Kuopio, Finland Hospital Sainte-Anne (F.C., B.C.D.), GHU-Paris, France IRCCS NEUROMED (G.D.G., V.E.), Pozzilli (IS), Italy Department of Neurosurgery (V.E.), Sapienza University of Rome, Italy Department of Clinical Neuropathology (Istvan Bodi, M.H.), King's College Hospital NHS Foundation Trust, Academic Neuroscience Center, Denmark Hill, King's College Hospital, London, United Kingdom Department of Epileptology (Krankenhaus Mara) (C.G.B., T.C.), Medical School, Campus Bielefeld-Bethel, Bielefeld University Department of Neuropathology (R.C.) Epilepsy Center (H.M.H.), University Hospital Erlangen, Germany Department of Neurology (P.M., A.K.), Motol Epilepsy Center, Second Medical Faculty, Charles University, Motol University Hospital, Prague, Czech Republic Center for Pediatric Neurology, Neurorehabilitation, and Epileptology (T.P., M.K.), Schoen-Clinic, Vogtareuth, Germany Research Institute "Rehabilitation, Transition, Palliation" (M.K.), PMU Salzburg, Austria Department of Neurology I (T.J.V.O.), Neuromed Campus, Kepler Universitätsklinikum Faculty of Medicine (T.J.V.O., M.A.), Johannes Kepler University Department of Neurosurgery (M.A.), Neuromed Campus, Kepler Universitätsklinikum, Linz, Austria Pediatric Neurosurgery Department (M.C.), Foundation Rothschild Hospital, Paris, France Epilepsy Center (S.N., E.K.), Department of Neurology, Ludwig-Maximilians University, Munich, Germany Epilepsy Centre (A.S.-B.) Department of Neurosurgery (C.F.S.), University Hospital, Freiburg, Germany Department of Neurology (C.O.), Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Turkey Swiss Epilepsy Center and Department of Neurology (K.K.), University Hospital, Zurich, Switzerland Neuroscience Department (Renzo Guerrini, C.B.), Pathology Unit (A.M.B.), and Neurosurgery Department (F.G.), Meyer Children's Hospital IRCCS, Florence, Italy University of Florence (Renzo Guerrini, C.B., F.G.), Florence, Italy Epilepsy Center Frankfurt Rhine-Main (F.R.), Department of Neurology, and LOEWE Center for Personalized Translational Epilepsy Research (CePTER), Goethe University Frankfurt, Frankfurt am Main Department of Neurology (F.R., K.M.), Epilepsy Center Hessen, Philipps University, Marburg, Germany Epilepsy Unit (Rita Garbelli, F.D.), Fondazione IRCCS Istituto Neurologico Carlo Besta, Milano, Italy Department of Pediatric Neurology (P.K., B.S.), Motol Epilepsy Center, Second Medical Faculty, Charles University, Motol University Hospital, Prague, Czech Republic Department of Pediatric Clinical Epileptology (A.A.A., J.T.), Sleep Disorders and Functional Neurology University Hospitals of Lyon (HCL), Lyon, France Paediatric Epilepsy Unit (A.A.A., V.S.A.-A., J.R.), Child Neurology Department and Neurosurgery Department, Hospital Sant Joan de Déu, Barcelona, Spain Department of Neurology (W.V.P.) Department of Neurosurgery (T.T.), University Hospital Leuven, Belgium Laboratory of Neuropathology (J.P., I.M.L.D.A.), Department of Neurosciences and Mental Health, Department of Neurology, Hospital de Santa Maria (CHULN)Lisbon, Portugal Clinical and Experimental Neurology (N.S., L.D.P.), Bambino Gesu' Children's Hospital, IRCCS, Rome, Italy Center for Rare and Complex Epilepsies (M.F., T.S.), Department of Pediatrics and Adolescent Medicine Department of Neurosurgery (K.R.), Medical University of Vienna, Austria Epilepsy Program (R.T.D., A.G.-N.), Hospital Ruber Internacional, Madrid, Spain Laboratory for Neuropathology (Savo Raicevic), Department of Pathology Department for Epilepsy (A.J.R.), Clinic of Neurology, Clinical Center of Serbia, Belgrade Medical Faculty (A.J.R.), University of Belgrade, Serbia Department of Neurosurgery (O.S.), Academic Center for Epileptology Department of Pathology (J.B.), Maastricht University Medical Center, The Netherlands and University Hospital Erlangen (Ingmar Blumcke), Neuropathology, Erlangen, Germany

Neurology. 2024 ; 102 (4) : e208007. [pub] 20240130

ISSN 1526-632X
Medvik
Source

BACKGROUND AND OBJECTIVE: Patients with presumed nonlesional focal epilepsy-based on either MRI or histopathologic findings-have a lower success rate of epilepsy surgery compared with lesional patients. In this study, we aimed to characterize a large group of patients with focal epilepsy who underwent epilepsy surgery despite a normal MRI and had no lesion on histopathology. Determinants of their postoperative seizure outcomes were further studied. METHODS: We designed an observational multicenter cohort study of MRI-negative and histopathology-negative patients who were derived from the European Epilepsy Brain Bank and underwent epilepsy surgery between 2000 and 2012 in 34 epilepsy surgery centers within Europe. We collected data on clinical characteristics, presurgical assessment, including genetic testing, surgery characteristics, postoperative outcome, and treatment regimen. RESULTS: Of the 217 included patients, 40% were seizure-free (Engel I) 2 years after surgery and one-third of patients remained seizure-free after 5 years. Temporal lobe surgery (adjusted odds ratio [AOR]: 2.62; 95% CI 1.19-5.76), shorter epilepsy duration (AOR for duration: 0.94; 95% CI 0.89-0.99), and completely normal histopathologic findings-versus nonspecific reactive gliosis-(AOR: 4.69; 95% CI 1.79-11.27) were significantly associated with favorable seizure outcome at 2 years after surgery. Of patients who underwent invasive monitoring, only 35% reached seizure freedom at 2 years. Patients with parietal lobe resections had lowest seizure freedom rates (12.5%). Among temporal lobe surgery patients, there was a trend toward favorable outcome if hippocampectomy was part of the resection strategy (OR: 2.94; 95% CI 0.98-8.80). Genetic testing was only sporadically performed. DISCUSSION: This study shows that seizure freedom can be reached in 40% of nonlesional patients with both normal MRI and histopathology findings. In particular, nonlesional temporal lobe epilepsy should be regarded as a relatively favorable group, with almost half of patients achieving seizure freedom at 2 years after surgery-even more if the hippocampus is resected-compared with only 1 in 5 nonlesional patients who underwent extratemporal surgery. Patients with an electroclinically identified focus, who are nonlesional, will be a promising group for advanced molecular-genetic analysis of brain tissue specimens to identify new brain somatic epilepsy genes or epilepsy-associated molecular pathways.

MeSH
Electroencephalography MeSH
Epilepsies, Partial * diagnostic imaging surgery MeSH
Epilepsy, Temporal Lobe * surgery MeSH
Epilepsy * diagnostic imaging surgery MeSH
Cohort Studies MeSH
Humans MeSH
Magnetic Resonance Imaging MeSH
Retrospective Studies MeSH
Treatment Outcome MeSH
Seizures MeSH
Check Tag
Humans MeSH
Publication type
Journal Article MeSH
Multicenter Study MeSH
Observational Study MeSH

Article

Myelin Pathology Beyond White Matter in Tuberous Sclerosis Complex (TSC) Cortical Tubers

Journal of neuropathology and experimental neurology. 2020 ; 79 (10) : 1054-1064. [pub] 20201001

J Neuropathol Exp Neurol
ISSN 1554-6578
Medvik
Source

Tuberous sclerosis complex (TSC) is a monogenetic disease that arises due to mutations in either the TSC1 or TSC2 gene and affects multiple organ systems. One of the hallmark manifestations of TSC are cortical malformations referred to as cortical tubers. These tubers are frequently associated with treatment-resistant epilepsy. Some of these patients are candidates for epilepsy surgery. White matter abnormalities, such as loss of myelin and oligodendroglia, have been described in a small subset of resected tubers but mechanisms underlying this phenomenon are unclear. Herein, we analyzed a variety of neuropathologic and immunohistochemical features in gray and white matter areas of resected cortical tubers from 46 TSC patients using semi-automated quantitative image analysis. We observed divergent amounts of myelin basic protein as well as numbers of oligodendroglia in both gray and white matter when compared with matched controls. Analyses of clinical data indicated that reduced numbers of oligodendroglia were associated with lower numbers on the intelligence quotient scale and that lower amounts of myelin-associated oligodendrocyte basic protein were associated with the presence of autism-spectrum disorder. In conclusion, myelin pathology in cortical tubers extends beyond the white matter and may be linked to cognitive dysfunction in TSC patients.

Article

The coding and non-coding transcriptional landscape of subependymal giant cell astrocytomas

Brain. 2020 ; 143 (1) : 131-149. [pub] 20200101

ISSN 1460-2156
Medvik
Source

Tuberous sclerosis complex (TSC) is an autosomal dominantly inherited neurocutaneous disorder caused by inactivating mutations in TSC1 or TSC2, key regulators of the mechanistic target of rapamycin complex 1 (mTORC1) pathway. In the CNS, TSC is characterized by cortical tubers, subependymal nodules and subependymal giant cell astrocytomas (SEGAs). SEGAs may lead to impaired circulation of CSF resulting in hydrocephalus and raised intracranial pressure in patients with TSC. Currently, surgical resection and mTORC1 inhibitors are the recommended treatment options for patients with SEGA. In the present study, high-throughput RNA-sequencing (SEGAs n = 19, periventricular control n = 8) was used in combination with computational approaches to unravel the complexity of SEGA development. We identified 9400 mRNAs and 94 microRNAs differentially expressed in SEGAs compared to control tissue. The SEGA transcriptome profile was enriched for the mitogen-activated protein kinase (MAPK) pathway, a major regulator of cell proliferation and survival. Analysis at the protein level confirmed that extracellular signal-regulated kinase (ERK) is activated in SEGAs. Subsequently, the inhibition of ERK independently of mTORC1 blockade decreased efficiently the proliferation of primary patient-derived SEGA cultures. Furthermore, we found that LAMTOR1, LAMTOR2, LAMTOR3, LAMTOR4 and LAMTOR5 were overexpressed at both gene and protein levels in SEGA compared to control tissue. Taken together LAMTOR1-5 can form a complex, known as the 'Ragulator' complex, which is known to activate both mTORC1 and MAPK/ERK pathways. Overall, this study shows that the MAPK/ERK pathway could be used as a target for treatment independent of, or in combination with mTORC1 inhibitors for TSC patients. Moreover, our study provides initial evidence of a possible link between the constitutive activated mTORC1 pathway and a secondary driver pathway of tumour growth.

Article

Histopathological Findings in Brain Tissue Obtained during Epilepsy Surgery

The New England journal of medicine. 2017 ; 377 (17) : 1648-1656.

N Engl J Med
ISSN 1533-4406
Medvik
Source

BACKGROUND: Detailed neuropathological information on the structural brain lesions underlying seizures is valuable for understanding drug-resistant focal epilepsy. METHODS: We report the diagnoses made on the basis of resected brain specimens from 9523 patients who underwent epilepsy surgery for drug-resistant seizures in 36 centers from 12 European countries over 25 years. Histopathological diagnoses were determined through examination of the specimens in local hospitals (41%) or at the German Neuropathology Reference Center for Epilepsy Surgery (59%). RESULTS: The onset of seizures occurred before 18 years of age in 75.9% of patients overall, and 72.5% of the patients underwent surgery as adults. The mean duration of epilepsy before surgical resection was 20.1 years among adults and 5.3 years among children. The temporal lobe was involved in 71.9% of operations. There were 36 histopathological diagnoses in seven major disease categories. The most common categories were hippocampal sclerosis, found in 36.4% of the patients (88.7% of cases were in adults), tumors (mainly ganglioglioma) in 23.6%, and malformations of cortical development in 19.8% (focal cortical dysplasia was the most common type, 52.7% of cases of which were in children). No histopathological diagnosis could be established for 7.7% of the patients. CONCLUSIONS: In patients with drug-resistant focal epilepsy requiring surgery, hippocampal sclerosis was the most common histopathological diagnosis among adults, and focal cortical dysplasia was the most common diagnosis among children. Tumors were the second most common lesion in both groups. (Funded by the European Union and others.).

MeSH
Databases as Topic MeSH
Child MeSH
Adult MeSH
Epilepsy etiology pathology surgery MeSH
Hippocampus pathology MeSH
Humans MeSH
Malformations of Cortical Development complications pathology MeSH
Brain pathology MeSH
Brain Neoplasms complications pathology MeSH
Temporal Lobe pathology MeSH
Age of Onset MeSH
Age Factors MeSH
Check Tag
Child MeSH
Adult MeSH
Humans MeSH
Male MeSH
Female MeSH
Publication type
Journal Article MeSH
Geographicals
Europe MeSH

Article

Specific pattern of maturation and differentiation in the formation of cortical tubers in tuberous sclerosis omplex (TSC): evidence from layer-specific marker expression

Journal of neurodevelopmental disorders. 2016 ; 8 (-) : 9. [pub] 20160401

J Neurodev Disord
ISSN 1866-1947
Medvik
Source

BACKGROUND: Tuberous sclerosis complex (TSC) is a multisystem disorder that results from mutations in the TSC1 or TSC2 genes, leading to constitutive activation of the mammalian target of rapamycin (mTOR) signaling pathway. Cortical tubers represent typical lesions of the central nervous system (CNS) in TSC. The pattern of cortical layering disruption observed in brain tissue of TSC patients is not yet fully understood, and little is known about the origin and phenotype of individual abnormal cell types recognized in tubers. METHODS: In the present study, we aimed to characterize dysmorphic neurons (DNs) and giant cells (GCs) of cortical tubers using neocortical layer-specific markers (NeuN, SMI32, Tbr1, Satb2, Cux2, ER81, and RORβ) and to compare the features with the histo-morphologically similar focal cortical dysplasia (FCD) type IIb. We studied a cohort of nine surgically resected cortical tubers, five FCD type IIb, and four control samples using immunohistochemistry and in situ hybridization. RESULTS: Cortical tuber displayed a prominent cell loss in all cortical layers. Moreover, we observed altered proportions of layer-specific markers within the dysplastic region. DNs, in both tubers and FCD type IIb, were found positive for different cortical layer markers, regardless of their laminar location, and their immunophenotype resembles that of cortical projection neurons. CONCLUSIONS: These findings demonstrate that, similar to FCD type IIb, cortical layering is markedly disturbed in cortical tubers of TSC patients. Distribution of these disturbances is comparable in all tubers and suggests a dysmaturation affecting early and late migratory patterns, with a more severe impairment of the late stage of maturation.

Publication type
Journal Article MeSH

Article

Epilepsy surgery in children and adolescents with malformations of cortical development--outcome and impact of the new ILAE classification on focal cortical dysplasia

Epilepsy research. 2014 ; 108 (9) : 1652-61.

Epilepsy Res
ISSN 1872-6844
Medvik
Source

UNLABELLED: To determine long-term efficacy and safety of epilepsy surgery in children and adolescents with malformations of cortical development (MCD) and to identify differences in seizure outcome of the various MCD subgroups. Special focus was set on the newly introduced International League Against Epilepsy (ILAE) classification of focal cortical dysplasia (FCD). STUDY DESIGN: This is a single center retrospective cross-sectional analysis of prospectively collected data. INCLUSION CRITERIA: age at surgery <18 years, pre-surgical evaluation and epilepsy surgery performed at the Vienna pediatric epilepsy center, histologically proven MCD, complete follow-up data for at least 12 months. Clinical variables evaluated: type and localization of MCD, type of surgery and a variety of clinical characteristics reported to be associated with (un-)favorable outcomes. MCD were classified following the existing classification schemes (Barkovich et al., 2012. Brain. 135, 1348-1369; Palmini et al., 2004. Neurology. 62, S2-S8) and the ILAE classification for FCD recently proposed by Blümcke in 2011. Seizure outcome was classified using the ILAE classification proposed by Wieser in 2001. RESULTS: 60 Patients (51.7% male) were included. Follow up was up to 14 (mean 4.4 ± 3.2) years. Mean age at surgery was 8.0 ± 6.0 (median 6.0) years; mean age at epilepsy onset was 2.9 ± 3.2 (median 2.0) years; duration of epilepsy before surgery was 4.8 ± 4.4 (median 3.0) years. 80% of the patients were seizure free at last follow-up. AEDs were successfully withdrawn in 56.7% of all patients. Extended surgery, lesion localization in the temporal lobes and absence of inter-ictal spikes in postsurgical EEG recordings were predictive of favorable seizure outcomes after surgery. However, no association was found between outcome and MCD sub-types. Epilepsy surgery is highly effective in carefully selected drug-resistant children with MCD. Surrogate markers for complete resection of the epileptogenic zone remain the only significant predictors for seizure freedom after surgery.

MeSH
Child MeSH
Electroencephalography MeSH
Epilepsy etiology surgery MeSH
Humans MeSH
Longitudinal Studies MeSH
Malformations of Cortical Development classification complications MeSH
Adolescent MeSH
Statistics, Nonparametric MeSH
Neurosurgery methods MeSH
Neuroimaging MeSH
Cross-Sectional Studies MeSH
Retrospective Studies MeSH
Severity of Illness Index * MeSH
Check Tag
Child MeSH
Humans MeSH
Adolescent MeSH
Male MeSH
Female MeSH
Publication type
Journal Article MeSH
Research Support, Non-U.S. Gov't MeSH

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