The Aim of this study was to evaluate the expression levels of miR-21, miR-221, miR-150, let-7a and miR-126a in peripheral blood of 71 patients with colorectal cancer and 80 matched healthy control individuals. We determined expression levels of these microRNAs in peripheral blood samples and used small nucleolar RNA (RNU48) as an internal control. Expression levels of miR-21 (p<0.0001) and miR-221 (p<0.0001) were significantly higher, whereas expression levels of miR-150 (p=0.0054) were significantly lower in the blood samples of patients with colorectal cancer in comparison to the control group. The combination of these three microRNAs enabled us to distinguish patients with colorectal cancer from healthy donors with a sensitivity of 80% and specificity of 74% (p<0.0001). We did not observe any correlation of the studied microRNAs with clinicopathological features of colorectal cancer, indicating that expression of these microRNAs is more likely related to the host response to the tumour than the tumour itself.
- MeSH
- chrom * škodlivé účinky toxicita MeSH
- chromozomální aberace MeSH
- epidemiologické studie MeSH
- genetická predispozice k nemoci * MeSH
- glutathion-S-transferasa fí * MeSH
- lidé MeSH
- polycyklické aromatické uhlovodíky škodlivé účinky toxicita MeSH
- polymorfismus genetický MeSH
- poškození DNA MeSH
- pracovní expozice * MeSH
- studie případů a kontrol MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- práce podpořená grantem MeSH
