Histone deacetylase (HDAC) inhibitors have shown beneficial effects in animal models of cardiovascular diseases. We hypothesized that HDAC inhibitor, sodium valproate (VPA), has cardiac and vascular protective effects in rats with pressure overload cardiac hypertrophy induced by transverse aortic constriction (TAC). Sections of the heart were visualized after hematoxylin and eosin staining, picrosirius red staining and immunohistochemistry. The expression of genes related to cardiac hypertrophy, fibrosis, and oxidative stress was determined by quantitative real-time polymerase chain reaction. The aortic ring tension analysis was conducted using both the ascending aorta and descending thoracic aorta. TAC increased the expression of hypertrophic, fibrotic, and oxidative stress genes, which was attenuated by VPA. In the ascending aorta with intact endothelium, there was a significant decrease in the relaxation response, which was recovered by VPA treatment. These results indicate that VPA has cardiac and vascular protective effects in rats with pressure overload cardiac hypertrophy.
- MeSH
- aorta chirurgie patofyziologie účinky léků MeSH
- arteriální tlak účinky léků MeSH
- fibróza MeSH
- funkce levé komory srdeční účinky léků MeSH
- hypertrofie levé komory srdeční metabolismus patofyziologie patologie prevence a kontrola MeSH
- inhibitory histondeacetylas farmakologie MeSH
- kyselina valproová farmakologie MeSH
- ligace MeSH
- modely nemocí na zvířatech MeSH
- myokard metabolismus patologie MeSH
- oxidační stres účinky léků MeSH
- potkani Sprague-Dawley MeSH
- regulace genové exprese MeSH
- remodelace komor účinky léků MeSH
- vazodilatace účinky léků MeSH
- vazodilatancia farmakologie MeSH
- zvířata MeSH
- Check Tag
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- MeSH
- lidé MeSH
- mikrochirurgie MeSH
- zánět čelní dutiny MeSH
- Check Tag
- lidé MeSH
- Geografické názvy
- Německo západní MeSH
