Cell viability during chronological aging and after apoptotic stimuli in some yeast mutants with altered mitochondrial morphology was followed; a function for the corresponding genes in the apoptotic process was assessed. MDM30 and DNM1, the genes encoding an F-box protein and the dynamin-related GTPase, respectively, are involved in triggering aging and apoptosis. In contrast, YME1, encoding a subunit of the mitochondrial inner membrane i-AAA proteinase complex, has a protective role in these processes. FIS1, the mitochondrial fission gene, might play a protective role after an apoptotic insult while it seems to promote cell death in aging cells.

• MeSH
• apoptóza imunologie   účinky léků   MeSH
• mikroskopie metody   využití   MeSH
• mitochondrie genetika   imunologie   MeSH
• oxidační stres genetika   imunologie   MeSH
• polynukleotidfosforylasa genetika   metabolismus   MeSH
• Saccharomyces cerevisiae genetika   růst a vývoj   MeSH
• stárnutí buněk fyziologie   genetika   MeSH
• zelené fluorescenční proteiny analýza   genetika   MeSH