Cyanobacterial strain ARC8 was isolated from seepage coming into the river Dračice, Františkov, Czech Republic, and was characterized using a polyphasic approach. Strain ARC8 showed a typical Nostoc-like morphology and in-depth morphological characterization indicated that it is a member of the genus Nostoc. Furthermore, in the 16S rRNA gene phylogeny inferred using Bayesian inference, maximum likelihood and neighbour joining methods, strain ARC8 clustered within the Nostoc sensu stricto clade. The phylogenetic distance and the positioning of strain ARC8 also indicated that it is a member of the genus Nostoc. Furthermore, the rbcL gene phylogeny along with the 16S-23S ITS secondary structure analysis also supported the findings from the 16S rRNA gene tree. In accordance with the International Code of Nomenclature for Algae, Fungi and Plants we describe a novel species of Nostoc with the name Nostoc neudorfense sp. nov.
- MeSH
- Bayesova věta MeSH
- DNA bakterií genetika MeSH
- fylogeneze * MeSH
- Nostoc klasifikace izolace a purifikace MeSH
- řeky mikrobiologie MeSH
- RNA ribozomální 16S genetika MeSH
- sekvenční analýza DNA MeSH
- techniky typizace bakterií MeSH
- zastoupení bazí MeSH
- Publikační typ
- časopisecké články MeSH
- Geografické názvy
- Česká republika MeSH
Celiac disease (CeD) is an immune-mediated enteropathy triggered by ingestion of gluten in genetically susceptible individuals. CeD is a global disease and estimated to affect approximately one percent of the global population. With advent of simple serological tests for the diagnosis, the number of individuals diagnosed with CeD is increasing exponentially. It was initially thought that gluten hypersensitivity in CeD is limited to small intestine only and all other features are secondary to malabsorption, but it is now recognized that the hypersensitivity to gluten is not limited to small intestine alone and may affect other organs such as skin, brain, and bones independent of intestinal involvement. CeD is now considered a multi-system disorder and their clinical presentation may be with gastrointestinal symptoms, called “classical CeD” or more often with non-gastrointestinal symptoms called “non-classical CeD”. These patients may present with short stature, anemia, liver dysfunction (asymptomatic increase in transaminases, chronic liver disease, autoimmune hepatitis), cutaneous manifestations (dermatitis herpetiformis, oral ulcers), reproductive diseases (infertility, recurrent abortions), neurological manifestations (ataxia, peripheral neuropathy), and metabolic disorders (osteopenia/osteoporosis). What determines these variable phenotypes remain unclear but likely is a result of genetic as well as environmental factors. Many of these patients with non-classical CeD are likely to report to specialists other than gastroenterologists such as hematologists, endocrinologists, rheumatologists or gynecologists. Unfortunately, the awareness about non-classical presentations of CeD amongst health care professionals remains low. There is an urgent need to increase awareness among health care professionals about varied manifestations of CeD in order to decrease the burden of undiagnosed CeD.
- MeSH
- anemie diagnóza epidemiologie imunologie MeSH
- autoimunitní tyreoiditida diagnóza epidemiologie imunologie MeSH
- autoprotilátky krev MeSH
- celiakie * diagnóza imunologie MeSH
- dermatitis herpetiformis diagnóza epidemiologie imunologie MeSH
- diabetes mellitus 1. typu diagnóza epidemiologie imunologie MeSH
- diferenciální diagnóza MeSH
- koagulopatie diagnóza epidemiologie imunologie MeSH
- kožní manifestace MeSH
- lidé MeSH
- metabolické nemoci kostí diagnóza epidemiologie imunologie MeSH
- nemoci jater diagnóza epidemiologie imunologie MeSH
- neurologické manifestace MeSH
- poruchy růstu diagnóza epidemiologie imunologie MeSH
- transglutaminasy imunologie krev MeSH
- ženská infertilita diagnóza epidemiologie imunologie MeSH
- Check Tag
- lidé MeSH
