JavaScript NENÍ povolen !

Prosím povolte JavaScript.

* Zobrazit nápovědu

Reset

Autor: Verleden, Geert M

4 záznamů v Medvik Filtry

Článek

COVID-19 progression in hospitalized patients using follow-up in vivo CT and ex vivo microCT

Geudens, Vincent
Autor Geudens, Vincent Laboratory of Respiratory Diseases and Thoracic Surgery, BREATHE, Department of Chrometa, KU Leuven, Leuven, Belgium
Van Slambrouck, Jan
Autor Van Slambrouck, Jan Laboratory of Respiratory Diseases and Thoracic Surgery, BREATHE, Department of Chrometa, KU Leuven, Leuven, Belgium
Aerts, Gitte
Autor Aerts, Gitte Laboratory of Respiratory Diseases and Thoracic Surgery, BREATHE, Department of Chrometa, KU Leuven, Leuven, Belgium
Willems, Lynn
Autor Willems, Lynn Laboratory of Respiratory Diseases and Thoracic Surgery, BREATHE, Department of Chrometa, KU Leuven, Leuven, Belgium
Goos, Tinne
Autor Goos, Tinne Laboratory of Respiratory Diseases and Thoracic Surgery, BREATHE, Department of Chrometa, KU Leuven, Leuven, Belgium
Kaes, Janne
Autor Kaes, Janne Laboratory of Respiratory Diseases and Thoracic Surgery, BREATHE, Department of Chrometa, KU Leuven, Leuven, Belgium
Zajacova, Andrea
Autor Zajacova, Andrea Prague Lung Transplant Program, Department of Pneumology, Motol University Hospital, 2nd Faculty of Medicine, Charles University in Prague, Prague, Czech Republic
Gyselinck, Iwein
Autor Gyselinck, Iwein Laboratory of Respiratory Diseases and Thoracic Surgery, BREATHE, Department of Chrometa, KU Leuven, Leuven, Belgium
Aelbrecht, Celine
Autor Aelbrecht, Celine Laboratory of Respiratory Diseases and Thoracic Surgery, BREATHE, Department of Chrometa, KU Leuven, Leuven, Belgium
Vermaut, Astrid
Autor Vermaut, Astrid Laboratory of Respiratory Diseases and Thoracic Surgery, BREATHE, Department of Chrometa, KU Leuven, Leuven, Belgium

Journal of thoracic disease. 2023 ; 15 (7) : 3646-3661. [pub] 20230703

J Thorac Dis
ISSN 2072-1439
Medvik
Zdroj

BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease-19 (COVID-19) which can lead to acute respiratory distress syndrome (ARDS) and evolve to pulmonary fibrosis. Computed tomography (CT) is used to study disease progression and describe radiological patterns in COVID-19 patients. This study aimed to assess disease progression regarding lung volume and density over time on follow-up in vivo chest CT and give a unique look at parenchymal and morphological airway changes in "end-stage" COVID-19 lungs using ex vivo microCT. METHODS: Volumes and densities of the lung/lobes of three COVID-19 patients were assessed using follow-up in vivo CT and ex vivo whole lung microCT scans. Airways were quantified by airway segmentations on whole lung microCT and small-partition microCT. As controls, three discarded healthy donor lungs were used. Histology was performed in differently affected regions in the COVID-19 lungs. RESULTS: In vivo, COVID-19 lung volumes decreased while density increased over time, mainly in lower lobes as previously shown. Ex vivo COVID-19 lung volumes decreased by 60% and all lobes were smaller compared to controls. Airways were more visible on ex vivo microCT in COVID-19, probably due to fibrosis and increased airway diameter. In addition, small-partition microCT showed more deformation of (small) airway morphology and fibrotic organization in severely affected regions with heterogeneous distributions within the same lung which was confirmed by histology. CONCLUSIONS: COVID-19-ARDS and subsequent pulmonary fibrosis alters lung architecture and airway morphology which is described using in vivo CT, ex vivo microCT, and histology.