BACKGROUND: The aim of this study was comparison the effectiveness of sequential and standard quadruple therapy on eradication of H. pylori infection. METHODS: This clinical trial study was conducted on 160 patients with dyspepsia or gastroduodenal ulcer. Patients were randomly divided into two groups. Group A (standard regimen) received omeprazole, amoxicillin, clarithromycin and bismuth subcitrate for 2 weeks. Group B (sequential regimen) received omeprazole and amoxicillin in 5 days and omeprazole, tinidazole and levofloxacin in 5 days. After the end of treatment regimens, 20 mg omeprazole was administered twice daily for 3 weeks. H. pylori eradication was assessed 2 months after antibiotic treatment via fecal antigen. RESULTS: Frequency of H. pylori eradication in group A and B was observed in 55 (68.8%) and 63 patients (78.8%), respectively. No significant difference was seen between two groups, regarding H. pylori eradication (p = 0.15). The most common side effects in group A, B were bitterness of mouth (63.8%) and nausea (16.2%), respectively (p H. pylori infection, higher rate of H. pylori eradication was seen in group B than group A. Thus, sequential regimen was a more appropriate regimen with fewer complications.

• MeSH
• Amoxicillin administration & dosage   MeSH
• Adult MeSH
• Helicobacter pylori MeSH
• Helicobacter Infections drug therapy   MeSH
• Clarithromycin administration & dosage   MeSH
• Drug Therapy, Combination MeSH
• Levofloxacin administration & dosage   MeSH
• Middle Aged MeSH
• Humans MeSH
• Omeprazole administration & dosage   MeSH
• Organometallic Compounds administration & dosage   MeSH
• Aged MeSH
• Tinidazole administration & dosage   MeSH
• Check Tag
• Adult MeSH
• Middle Aged MeSH
• Humans MeSH
• Male MeSH
• Aged MeSH
• Female MeSH
• Publication type
• Journal Article MeSH
• Clinical Trial MeSH
• Comparative Study MeSH

• MeSH
• Amebiasis drug therapy   MeSH
• Anthelmintics MeSH
• Giardiasis drug therapy   MeSH
• Helminthiasis drug therapy   MeSH
• Tinidazole therapeutic use   MeSH
• Trichomonas Vaginitis drug therapy   MeSH
• Publication type
• Congress MeSH

• Conspectus
• Farmacie. Farmakologie
• NML Fields
• farmakoterapie
• farmacie a farmakologie
• parazitologie