An increased number of sulfate-reducing bacteria is often isolated from faeces of patients with gastrointestinal diseases, which can be the cause of the development of bowel inflammation. Frequent use of antibiotics causes the resistance of intestinal microorganisms and ineffective treatment of these diseases. The antimicrobial activity and biological properties of the selected ring-substituted 8-hydroxyquinoline-2-carboxanilides against Desulfovibrio piger Vib-7 were studied. The addition of these compounds in the cultivation medium inhibited the bacterial growth and the process of sulfate reduction dose-dependently. A significant cytotoxic activity under the influence of ring-substituted 8-hydroxyquinoline-2-carboxanilides was determined. The strongest cytotoxic effect of the derivatives was observed for compounds 8-hydroxy-N-(3-methoxyphenyl)quinoline-2-carboxamide and 8-hydroxy-N-(3-trifluoromethylphenyl)quinoline-2-carboxamide that caused a low survival of D. piger Vib-7 in concentration 17 μM and high toxicity rates.
- Klíčová slova
- 8-hydroxychinolin-2-karboxanilidy, redukce síranu, Desulfovibrio piger,
- MeSH
- antibakteriální látky farmakologie chemie klasifikace MeSH
- Bacteria klasifikace metabolismus MeSH
- bakteriologické techniky metody MeSH
- Desulfovibrio * klasifikace patogenita účinky léků MeSH
- hydroxychinoliny * farmakologie klasifikace MeSH
- idiopatické střevní záněty mikrobiologie MeSH
- mikrobiální viabilita účinky léků MeSH
- ulcerózní kolitida * farmakoterapie mikrobiologie patologie MeSH
- vyvíjení léků MeSH
- Publikační typ
- práce podpořená grantem MeSH
- MeSH
- Desulfovibrio patogenita MeSH
- divoká zvířata MeSH
- enteritida veterinární MeSH
- savci MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
