An increased number of sulfate-reducing bacteria is often isolated from faeces of patients with gastrointestinal diseases, which can be the cause of the development of bowel inflammation. Frequent use of antibiotics causes the resistance of intestinal microorganisms and ineffective treatment of these diseases. The antimicrobial activity and biological properties of the selected ring-substituted 8-hydroxyquinoline-2-carboxanilides against Desulfovibrio piger Vib-7 were studied. The addition of these compounds in the cultivation medium inhibited the bacterial growth and the process of sulfate reduction dose-dependently. A significant cytotoxic activity under the influence of ring-substituted 8-hydroxyquinoline-2-carboxanilides was determined. The strongest cytotoxic effect of the derivatives was observed for compounds 8-hydroxy-N-(3-methoxyphenyl)quinoline-2-carboxamide and 8-hydroxy-N-(3-trifluoromethylphenyl)quinoline-2-carboxamide that caused a low survival of D. piger Vib-7 in concentration 17 μM and high toxicity rates.
- Keywords
- 8-hydroxychinolin-2-karboxanilidy, redukce síranu, Desulfovibrio piger,
- MeSH
- Anti-Bacterial Agents pharmacology chemistry classification MeSH
- Bacteria classification metabolism MeSH
- Bacteriological Techniques methods MeSH
- Desulfovibrio * classification pathogenicity drug effects MeSH
- Hydroxyquinolines * pharmacology classification MeSH
- Inflammatory Bowel Diseases microbiology MeSH
- Microbial Viability drug effects MeSH
- Colitis, Ulcerative * drug therapy microbiology pathology MeSH
- Drug Development MeSH
- Publication type
- Research Support, Non-U.S. Gov't MeSH
