• Keywords
• kulhání,
• MeSH
• Walking * MeSH
• Diagnostic Techniques and Procedures classification   MeSH
• Diagnosis, Differential * MeSH
• Child MeSH
• Humans MeSH
• Movement Disorders * diagnostic imaging   diagnosis   etiology   MeSH
• Check Tag
• Child MeSH
• Humans MeSH
• Publication type
• Review MeSH

In motor functional neurological disorders (mFND), relationships between interoception (a construct of high theoretical relevance to its pathophysiology) and neuroanatomy have not been previously investigated. This study characterized white matter in mFND patients compared to healthy controls (HCs), and investigated associations between fiber bundle integrity and cardiac interoception. Voxel-based analysis and tractography quantified fractional anisotropy (FA) in 38 mFND patients compared to 38 HCs. Secondary analyses compared functional seizures (FND-seiz; n = 21) or functional movement disorders (n = 17) to HCs. Network lesion mapping identified gray matter origins of implicated fiber bundles. Within-group mFND analyses investigated relationships between FA, heartbeat tracking accuracy and interoceptive trait prediction error (discrepancies between interoceptive accuracy and self-reported bodily awareness). Results were corrected for multiple comparisons, and all findings were adjusted for depression and trait anxiety. mFND and HCs did not show any between-group interoceptive accuracy or FA differences. However, the FND-seiz subgroup compared to HCs showed decreased integrity in right-lateralized tracts: extreme capsule/inferior fronto-occipital fasciculus, arcuate fasciculus, inferior longitudinal fasciculus, and thalamic/striatum to occipital cortex projections. These alterations originated predominantly from the right temporoparietal junction and inferior temporal gyrus. In mFND patients, individual differences in interoceptive accuracy and interoceptive trait prediction error correlated with fiber bundle integrity originating from the insula, temporoparietal junction, putamen and thalamus among other regions. In this first study investigating brain-interoception relationships in mFND, individual differences in interoceptive accuracy and trait prediction error mapped onto multimodal integration-related fiber bundles. Right-lateralized limbic and associative tract disruptions distinguished FND-seiz from HCs.

• MeSH
• White Matter * diagnostic imaging   pathology   physiopathology   MeSH
• Biological Variation, Population physiology   MeSH
• Adult MeSH
• Interoception physiology   MeSH
• Middle Aged MeSH
• Humans MeSH
• Young Adult MeSH
• Cerebral Cortex MeSH
• Movement Disorders * diagnostic imaging   pathology   physiopathology   MeSH
• Anticipation, Psychological physiology   MeSH
• Gray Matter * diagnostic imaging   pathology   physiopathology   MeSH
• Heart Rate physiology   MeSH
• Diffusion Tensor Imaging * MeSH
• Check Tag
• Adult MeSH
• Middle Aged MeSH
• Humans MeSH
• Young Adult MeSH
• Male MeSH
• Female MeSH
• Publication type
• Journal Article MeSH
• Research Support, Non-U.S. Gov't MeSH
• Research Support, N.I.H., Extramural MeSH

Evaluation of motions is the basis for the diagnosis of human locomotor system disorders. Analyses are usually focused on the performance components of this system, i.e. on the skeleton and muscles. However, where comprehensive diagnosis is to be obtained, the motor system must be evaluated as a whole, without omitting any of its parts. So, evaluation of the control function is very important to body motion evaluation. The method that is normally used to evaluate the activity of brain is electroencephalography, which is superior to other brain activity-evaluating methods in many respects. However, EEG has also a major drawback, namely, it cannot precisely locate the activated and deactivated brain regions. This drawback can be avoided by using the sLORETA neurophysiological program, a tool that can transform EEG data to 3D brain images and finding application across a wide range of clinical branches of medicine – neurology, neurophysiology, psychiatry, physiotherapy and also in sports.

• MeSH
• Electroencephalography methods   MeSH
• Kinesiology, Applied methods   MeSH
• Humans MeSH
• Locomotion * physiology   MeSH
• Magnetic Resonance Imaging methods   MeSH
• Movement physiology   MeSH
• Movement Disorders diagnostic imaging   etiology   physiopathology   MeSH
• Rehabilitation methods   MeSH
• Imaging, Three-Dimensional MeSH
• Check Tag
• Humans MeSH
• Publication type
• Research Support, Non-U.S. Gov't MeSH

• MeSH
• Osteoarthritis, Spine diagnostic imaging   MeSH
• Diagnostic Errors MeSH
• Interprofessional Relations ethics   MeSH
• Humans MeSH
• Magnetic Resonance Imaging MeSH
• Meningioma * diagnostic imaging   surgery   MeSH
• Movement Disorders diagnostic imaging   etiology   MeSH
• Aged, 80 and over MeSH
• Check Tag
• Humans MeSH
• Aged, 80 and over MeSH
• Female MeSH
• Publication type
• Case Reports MeSH