... -- 5.1 Polynomials and Rational Functions 201 -- 5.2 Evaluation of Continued Fractions 206 -- 5.3 Series ... ... -- 5.10 Polynomial Approximation from Cheby shev Coefficients 241 -- 5.11 Economization of Power Series ... ... of Unevenly Sampled Data 685 -- 13.9 Computing Fourier Integrals Using the FFT 692 -- 13.10 Wavelet ... ... 721 -- 14.2 Do Two Distributions Have the Same Means or Variances? ... ... r 773 -- 15.1 Least Squares as a Maximum Likelihood Estimator 776 -- 15.2 Fitting Data to a Straight ...
3rd ed. xxi, 1235 s. : il. ; 27 cm + 1 CD-ROM
- MeSH
- Mathematical Computing MeSH
- Mathematics MeSH
- Numerical Analysis, Computer-Assisted * MeSH
- Publication type
- Monograph MeSH
- Conspectus
- Počítačová věda. Výpočetní technika. Informační technologie
- NML Fields
- přírodní vědy
- přírodní vědy
... 486 -- Practical Aspects of Data Analysis 487 -- Purposes of Statistical Analysis 487 -- The Process ... ... of Data Analysis 487 Preparation of the Data for Analysis 487 Description of the Sample 488 Testing ... ... Time 513 -- Analysis of Case Study Data 513 Survival Analysis 513 Time-Series Analysis 514 -- 20 Using ... ... Procedures 583 One-Way Analysis of Variance 583 Factorial Analyses of Variance 586 Analysis of Covariance ... ... Collection Process 625 -- Evidence from the Data Analysis Process 625 -- Evidence from Data Analysis ...
4th ed. xx, 840 s. : il.
BACKGROUND/AIMS: The activity of oxaliplatin (OHP) and irinotecan (CPT) alone or in combination with 5-fluorouracil (5-FU) in advanced colorectal cancer is comparable, but there are limited data on the effectiveness of oxaliplatin in patients pretreated by irinotecan. METHODOLOGY: We have analyzed retrospectively the survival of 77 consecutive advanced colorectal cancer patients treated with OHP after previous CPT therapy. Multivariate analysis was performed by Cox regression method, with the results expressed as hazard ratio (HR). RESULTS: The median survival from the start of OHP therapy was 10.7 months (1-year survival 43%). The median survival was not reached in 10 patients treated by hepatic arterial infusion of OHP (>10.6 months). The median survival from the diagnosis of advanced/metastatic disease was 34.3 months. On multivariate analysis, hemoglobin <125g/L (HR=2.42), neutrophils <5200 per microL (HR=0.36), duration of advanced/metastatic disease <21 months (HR=2.40) and interval from last CPT administration <3 months (HR=0.27) were statistically significant (p<0.05) independent predictors of survival from the start of OHP treatment, but only hemoglobin (HR=2.07), neutrophils (HR=0.32) and CEA <100microg/L (HR=0.44) were independent predictors of survival from the last CPT. There were 4 treatment-induced deaths after combination of OHP and raltitrexed (TOMOX). CONCLUSIONS: More than 40% of patients pretreated by irinotecan survived 1 year after start of OHP therapy. The therapy was similarly effective as a second or higher line of treatment. Hemoglobin levels and neutrophil count were independent factors associated with survival. The number of toxic deaths observed after TOMOX is alarming.
- MeSH
- Survival Analysis MeSH
- Analysis of Variance MeSH
- Time Factors MeSH
- Financing, Organized MeSH
- Fluorouracil therapeutic use MeSH
- Risk Assessment MeSH
- Camptothecin analogs & derivatives therapeutic use MeSH
- Colorectal Neoplasms surgery mortality pathology MeSH
- Humans MeSH
- Neoplasm Recurrence, Local drug therapy mortality pathology MeSH
- Multivariate Analysis MeSH
- Follow-Up Studies MeSH
- Organoplatinum Compounds therapeutic use MeSH
- Palliative Care methods MeSH
- Probability MeSH
- Proportional Hazards Models MeSH
- Antineoplastic Combined Chemotherapy Protocols therapeutic use MeSH
- Retrospective Studies MeSH
- Drug Administration Schedule MeSH
- Neoplasm Staging MeSH
- Treatment Outcome MeSH
- Dose-Response Relationship, Drug MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Comparative Study MeSH
... investigation, 6 -- 3 Choosing a test: a key, 7 -- Remember — eight steps to successful data analysis ... ... -- Trends, predictions and time series, 59 Displaying data: comparing more than two variables, 63 Associations ... ... , 63 -- Multiple trends, time series and predictions, 64 -- 7 The tests t : tests td look at differences ... ... component analysis (PCA) and factor analysis, 200 -- Contents ěx -- Canonical variate analysis (CVA) ... ... , 205 Discriminant function analysis> 205 Multivariate analysis of variance (manová), 210 Multivariate ...
2nd ed. 248 s.
