Cytochrome P450 (CYP) is a major group of enzymes, which conduct Phase I metabolism. Among commonly used animal models, the pig has been suggested as the most suitable model for investigating drug metabolism in human beings. Moreover, porcine CYP2A19 and CYP2E1 are responsible for the biotransformation of both endogenous and exogenous compounds such as 3-methylindole (skatole), sex hormones and food compounds. However, little is known about the regulation of porcine CYP2A19 and CYP2E1. In this MiniReview, we summarise the current knowledge about the regulation of porcine CYP2A19 and CYP2E1 by environmental, biological and dietary factors. Finally, we reflect on the need for further research, to clarify the interaction between active feed components and the porcine CYP system.
- MeSH
- Biotransformation MeSH
- Cytochrome P-450 CYP2E1 genetics metabolism MeSH
- Cytochrome P-450 CYP2A6 genetics metabolism MeSH
- Animal Feed * MeSH
- Humans MeSH
- Gonadal Steroid Hormones metabolism MeSH
- Swine metabolism MeSH
- Sequence Homology MeSH
- Skatole metabolism MeSH
- Xenobiotics metabolism MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
