Subclinical hypothyroidism is the most widely spread thyroid dysfunction with normal serum levels of free thyroxine (FT4) and elevated serum thyrotropin (TSH) levels. The work was initiated to study prevalence of subclinical hypothyroidism among women aged from 18 to 65 residing in Andijan region, Republic of Uzbekistan. It turned to be 12.4% confidently increasing to 28.3% when TSH upper limit was reduced. Regardless of TSH upper limit subclinical hypothyroidism frequency is higher among women over 40 years of age than among those under 30.

• Klíčová slova
• thyroid peroxidase antibodies,
• MeSH
• dospělí MeSH
• hormony štítné žlázy krev   MeSH
• hypotyreóza * diagnóza   epidemiologie   MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladý dospělý MeSH
• prevalence MeSH
• thyreotropin krev   MeSH
• thyroxin krev   MeSH
• věkové rozložení MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladý dospělý MeSH
• ženské pohlaví MeSH
• Geografické názvy
• Uzbekistán MeSH

Considerable morbidity upon spontaneous wound healing (phlegmons, osteomyelitis, and purulent osteoarthritis of metatarsophalangeal joint) as well as loss of the diseased foot's walking ability are among the reasons for transition to plastic surgery in management tactics. The longer foot lesion persists, the higher probability of amputation. Improvement of treatment of both wound and ulcer lesions by means of reconstructive surgery in patients with diabetic foot syndrome was the main aim of the study. Outcomes of treatment of 460 patients managed at the Center for the Scientific and Clinical Study of Endocrinology, within the period from 2001 to 2009 were analyzed. Size, form, depth and localization of a wound, tissue composition of the wound bed as well as circulation in skin flaps caused the choice of specific operation: autodermoplasty by Parin (with the split-thickness skin flap), local tissue plastic operation (with the sliding or inter-advancing skin flaps, flaps from previously amputated toe or Indian flaps), plastic operation with the controlled tissue tension or combined plastic operation. Reconstructive foot wound surgery allows restoring load-bearing function of the extremity much earlier in contrast to spontaneous healing, reducing incidence of post-operative and long-term complications, amputations and re-amputations, decreasing period of treatment.

• MeSH
• diabetes mellitus 1. typu komplikace   MeSH
• diabetes mellitus 2. typu komplikace   MeSH
• diabetická noha * chirurgie   MeSH
• hojení ran MeSH
• komplikace diabetu chirurgie   MeSH
• lidé středního věku MeSH
• lidé MeSH
• plastická chirurgie metody   MeSH
• zákroky plastické chirurgie metody   MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH