Lechner, Matt*
Dotaz
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- MeSH
- genetická predispozice k nemoci MeSH
- lidé MeSH
- roztroušená skleróza * genetika MeSH
- stupeň závažnosti nemoci MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- dopisy MeSH
BACKGROUND: Definitions are essential for effective communication and discourse, particularly in science. They allow the shared understanding of a thought or idea, generalization of knowledge, and comparison across scientific investigation. The current terms describing olfactory dysfunction are vague and overlapping. SUMMARY: As a group of clinical olfactory researchers, we propose the standardization of the terms "dysosmia," "anosmia," "hyposmia," "normosmia," "hyperosmia," "olfactory intolerance," "parosmia," and "phantosmia" (or "olfactory hallucination") in olfaction-related communication, with specific definitions in this text. KEY MESSAGES: The words included in this paper were determined as those which are most frequently used in the context of olfactory function and dysfunction, in both clinical and research settings. Despite widespread use in publications, however, there still exists some disagreement in the literature regarding the definitions of terms related to olfaction. Multiple overlapping and imprecise terms that are currently in use are confusing and hinder clarity and universal understanding of these concepts. There is a pressing need to have a unified agreement on the definitions of these olfactory terms by researchers working in the field of chemosensory sciences. With the increased interest in olfaction, precise use of these terms will improve the ability to integrate and advance knowledge in this field.
... Transfusionsreaktionen durch weitgehend leukozyten- und thrombozytenfreie Erythrozytenkonserven 194 -- Lechner ...
Bibliotheca Haematologica ; No. 37
viii, 466 stran : ilustrace, tabulky ; 25 cm
Bericht der 14. Tagung der Deutschen Gesellschaft für Bluttransfusionen in Giessen, April 1970.
- MeSH
- biomedicínský výzkum MeSH
- krev MeSH
- krevní transfuze MeSH
- náhražky plazmy MeSH
- Publikační typ
- abstrakty MeSH
- kongresy MeSH
- sborníky MeSH
- Konspekt
- Lékařské vědy. Lékařství
- NLK Obory
- hematologie a transfuzní lékařství
Objectives Sinonasal mucosal melanoma (SNMM) is an extremely rare and challenging sinonasal malignancy with a poor prognosis. Standard treatment involves complete surgical resection, but the role of adjuvant therapy remains unclear. Crucially, our understanding of its clinical presentation, course, and optimal treatment remains limited, and few advancements in improving its management have been made in the recent past. Methods We conducted an international multicenter retrospective analysis of 505 SNMM cases from 11 institutions across the United States, United Kingdom, Ireland, and continental Europe. Data on clinical presentation, diagnosis, treatment, and clinical outcomes were assessed. Results One-, three-, and five-year recurrence-free and overall survival were 61.4, 30.6, and 22.0%, and 77.6, 49.2, and 38.3%, respectively. Compared with disease confined to the nasal cavity, sinus involvement confers significantly worse survival; based on this, further stratifying the T3 stage was highly prognostic ( p < 0.001) with implications for a potential modification to the current TNM staging system. There was a statistically significant survival benefit for patients who received adjuvant radiotherapy, compared with those who underwent surgery alone (hazard ratio [HR] = 0.74, 95% confidence interval [CI]: 0.57-0.96, p = 0.021). Immune checkpoint blockade for the management of recurrent or persistent disease, with or without distant metastasis, conferred longer survival (HR = 0.50, 95% CI: 0.25-1.00, p = 0.036). Conclusions We present findings from the largest cohort of SNMM reported to date. We demonstrate the potential utility of further stratifying the T3 stage by sinus involvement and present promising data on the benefit of immune checkpoint inhibitors for recurrent, persistent, or metastatic disease with implications for future clinical trials in this field.
- Publikační typ
- časopisecké články MeSH
... .; Lechner, ?.; Wagner, A.; Emminger, W. ... ... therapeutischen Zytapheresen und Plasmaaustauschbehandlungen 241 Y -- Lymphokine/Immuntherapie -- Lohmann-Matthes ... ... A.; Lohmann-Matthes, M.-L. ... ... M.; Lohmann-Matthes, M.-L. ... ... W.; Gadner, H.; Hajek-Rosenmayr, A.; Fischer-Hinterberger, M.; Kos, M.; Emminger, W.; Panzer, S.; Lechner ...
Beiträge zur Infusionstherapie und klinische Ernährung ; Band 18
412 s. : il.
