Q112421246
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The aim of this work was to optimize and validate a simple and rapid method for the direct determination of total platinum in blood serum of chemotherapy patients. The method is based on the quantification of platinum by electrothermal atomic absorption spectrometry (ET-AAS) with the Zeeman background correction after appropriate dilution of samples with 0.2% (v/v) Triton X-100 using the optimized temperature program (pyrolysis and atomization temperatures 1400 °C and 2550 °C, respectively). The validated range of quantification was 0.11–2.15 mol l1, RSD was better than 9 %. The accuracy was checked by comparing the results with those obtained by inductively coupled plasma mass spectrometry (ICP-MS). The optimized ET-AAS method is now successfully used for investigation of some pharmacokinetic parameters in a clinical study comparing intravenous and intraperitoneal infusion of carboplatin (combined with paclitaxel).
The present article provides results of analyses of trace elements from dental tissues and their relations with social status, dietary habits, and pathological changes in vertebras in the skeletal remains from the former family crypt in the St. Catherine Church ruins. Three aristocratic families (the Labsánszkys from the Korlátko castle, the Erdődys and the Apponyis) were buried under St. Catherine church in the 18th century. Skeletal material from one of the three crypts was investigated. The family allegiance of these skeletal remains is still not known; our considerations based on the historical sources indicated the Labsánszky family. The concentrations of Ca, Sr and Zn in 8 permanent teeth obtained from 8 individuals were analysed. The number of analysed teeth was limited by the number of buried individuals and the preservation state of the skulls. Concentrations of the trace elements and their ratios – a relatively low content of strontium and a higher concentration of zinc – indicated a rich protein diet. Despite the small number of teeth analysed, the results are relatively homogenous and show that probably all of the buried persons had belonged to a higher society. The results were also confirmed indirectly by the palaeopathological findings in the bones of the postcranial skeleton. The Forestier disease (DISH) was diagnosed in three individuals at minimum, which can also indicate that they suffered from obesity or type 2 diabetes. However, DISH is a hereditary disease; therefore we must also consider the familiar appearance.
- MeSH
- antropologie fyzická metody MeSH
- difuzní idiopatická skeletální hyperostóza patologie MeSH
- financování organizované MeSH
- kosti a kostní tkáň chemie MeSH
- lidé MeSH
- stopové prvky analýza MeSH
- stravovací zvyklosti etnologie MeSH
- stroncium analýza MeSH
- vápník analýza MeSH
- zinek analýza MeSH
- zuby chemie MeSH
- Check Tag
- lidé MeSH
The interest in the determination of different Sb species in natural waters is due to the fact that their toxicological and physiological behavior strongly depends on their chemical forms and oxidation states. The purpose of this article is to review and evaluate methods for Sb speciation in waters based on selective hydride generation of Sb (III) and on coupling of different separation techniques (liquid-liquid extraction, solid phase extraction, cloud point extraction, ion-exchange HPLC and GC) with atomic spectrometric methods (AAS, atomic emission spectrometry and atomic fluorescence spectrometry). This review covers the literature published over the period 1998-2006.
