• Klíčová slova
• avatrombopag, doptelet,
• MeSH
• klinická studie jako téma MeSH
• lidé MeSH
• receptory thrombopoetinu * aplikace a dávkování   MeSH
• statistika jako téma MeSH
• trombocytopenie * farmakoterapie   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• komentáře MeSH

• Klíčová slova
• avatrombopag, doptelet,
• MeSH
• farmakologické jevy MeSH
• klinická studie jako téma MeSH
• lékové interakce MeSH
• lidé MeSH
• randomizované kontrolované studie jako téma MeSH
• receptory thrombopoetinu * aplikace a dávkování   MeSH
• statistika jako téma MeSH
• trombocytopenická purpura farmakoterapie   MeSH
• trombocytopenie * farmakoterapie   patologie   MeSH
• trombocyty účinky léků   MeSH
• Check Tag
• lidé MeSH

• Klíčová slova
• Doptelet (avatrombopag),
• MeSH
• dospělí MeSH
• idiopatická trombocytopenická purpura * farmakoterapie   MeSH
• imunosupresiva MeSH
• lidé MeSH
• nemoci jater komplikace   MeSH
• receptory thrombopoetinu agonisté   terapeutické užití   MeSH
• trombocyty účinky léků   MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH

There are currently three thrombopoietin receptor agonists (TPO-RAs) approved in Europe for treating patients with immune thrombocytopenia (ITP): romiplostim (Nplate®), eltrombopag (Revolade®), and avatrombopag (Doptelet®). However, comparative clinical data between these TPO-RAs are limited. Therefore, the purpose of this study was to perform a literature review and seek expert opinion on the relevance and strength of the evidence concerning the use of TPO-RAs in adults with ITP. A systematic search was conducted in PubMed and Embase within the last 10 years and until June 20, 2022. A total of 478 unique articles were retrieved and reviewed for relevance. The expert consensus panel comprised ITP senior hematologists from eight countries across Central Europe. The modified Delphi method, consisting of two survey rounds, a teleconference and email correspondence, was used to reach consensus. Forty articles met the relevancy criteria and are included as supporting evidence, including five meta-analyses analyzing all three European-licensed TPO-RAs and comprising a total of 31 unique randomized controlled trials (RCTs). Consensus was reached on seven statements for the second-line use of TPO-RAs in the management of adult ITP patients. In addition, the expert panel discussed TPO-RA treatment in chronic ITP patients with mild/moderate COVID-19 and ITP patients in the first-line setting but failed to reach consensus. This work will facilitate informed decision-making for healthcare providers treating adult ITP patients with TPO-RAs. However, further studies are needed on the use of TPO-RAs in the first-line setting and specific patient populations.

• MeSH
• benzoáty terapeutické užití   MeSH
• COVID-19 * MeSH
• dospělí MeSH
• hydraziny terapeutické užití   MeSH
• idiopatická trombocytopenická purpura * farmakoterapie   chemicky indukované   MeSH
• konsensus MeSH
• lidé MeSH
• receptory Fc terapeutické užití   MeSH
• receptory thrombopoetinu agonisté   MeSH
• rekombinantní fúzní proteiny terapeutické užití   MeSH
• thrombopoetin terapeutické užití   MeSH
• trombocytopenie * chemicky indukované   MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• systematický přehled MeSH