křídlatka japonská Dotaz Zobrazit nápovědu
- MeSH
- fytoterapie MeSH
- léčivé rostliny MeSH
- lidé MeSH
- Reynoutria japonica * chemie MeSH
- Check Tag
- lidé MeSH
Knotweeds (Reynoutria Houtt.) are plants native to the Far East. Japanese knotweed was introduced from Japan to the unsuspecting West by the horticultural activities of Philippe von Siebold via his nursery at Leiden in the 1840s. By 1854, the plant had arrived at the Royal Botanic Gardens in Edinburgh. The plants were then sold by a large number of commercial nursery gardens around the country. Further vegetative spread followed naturally along watercourses. The knotweed is currently extremely persistant invasive plant. There is also an important source of many bioactive substances which could be used in biomedicine. The article discusses biomedically relevant constituents and its pharmacological and toxicological properties.
- Klíčová slova
- křídlatka japonská, polydatin,
- MeSH
- antiflogistika nesteroidní MeSH
- antikarcinogenní látky MeSH
- antimutagenní látky MeSH
- antioxidancia MeSH
- antitumorózní látky fytogenní MeSH
- fytoterapie MeSH
- glukosidy farmakologie chemie terapeutické užití MeSH
- inhibitory agregace trombocytů MeSH
- inhibitory enzymů MeSH
- kořeny rostlin MeSH
- léčivé rostliny MeSH
- léky rostlinné čínské MeSH
- lidé MeSH
- listy rostlin MeSH
- Polygonaceae MeSH
- resveratrol MeSH
- Reynoutria japonica * MeSH
- rostlinné extrakty MeSH
- stilbeny farmakologie chemie terapeutické užití MeSH
- tradiční čínská medicína * MeSH
- zavlečené druhy MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- práce podpořená grantem MeSH
- přehledy MeSH
- MeSH
- antioxidancia chemie izolace a purifikace MeSH
- chemické techniky analytické metody MeSH
- financování organizované MeSH
- regresní analýza MeSH
- Reynoutria japonica chemie MeSH
- statistické modely MeSH
- stilbeny chemie izolace a purifikace MeSH
- vysokoúčinná kapalinová chromatografie metody využití MeSH
Microorganisms that cause chronic infections exist predominantly as surface-attached stable communities known as biofilms. Microbial cells in biofilms are highly resistant to conventional antibiotics and other forms of antimicrobial treatment; therefore, modern medicine tries to develop new drugs that exhibit anti-biofilm activity. We investigated the influence of a plant polyphenolic compound resveratrol (representative of the stilbene family) on the opportunistic pathogen Trichosporon cutaneum. Besides the influence on the planktonic cells of T. cutaneum, the ability to inhibit biofilm formation and to eradicate mature biofilm was studied. We have tested resveratrol as pure compound, as well as resveratrol in complex plant extract-the commercially available dietary supplement Regrapex-R-forte, which contains the extract of Vitis vinifera grape and extract of Polygonum cuspidatum root. Regrapex-R-forte is rich in stilbenes and other biologically active substances. Light microscopy imaging, confocal microscopy, and crystal violet staining were used to quantify and visualize the biofilm. The metabolic activity of biofilm-forming cells was studied by the tetrazolium salt assay. Amphotericin B had higher activity against planktonic cells; however, resveratrol and Regrapex-R-forte showed anti-biofilm effects, both in inhibition of biofilm formation and in the eradication of mature biofilm. The minimum biofilm eradicating concentration (MBEC80) for Regrapex-R-forte was found to be 2222 mg/L (in which resveratrol concentration is 200 mg/L). These methods demonstrated that Regrapex-R-forte can be employed as an anti-biofilm agent, as it has similar effect as amphotericin B (MBEC80 = 700 mg/L), which is routinely used in clinical practice.
- MeSH
- amfotericin B farmakologie MeSH
- antifungální látky farmakologie MeSH
- biofilmy účinky léků růst a vývoj MeSH
- mikrobiální testy citlivosti MeSH
- resveratrol farmakologie MeSH
- Reynoutria japonica chemie MeSH
- rostlinné extrakty farmakologie MeSH
- Trichosporon účinky léků růst a vývoj metabolismus MeSH
- Vitis chemie MeSH
- Publikační typ
- časopisecké články MeSH
