• MeSH
• dospělí MeSH
• genotyp * MeSH
• genotypizační techniky MeSH
• kosterní svalová vlákna * MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladiství MeSH
• mladý dospělý MeSH
• polymorfismus genetický MeSH
• sekvenční analýza DNA využití   MeSH
• sportovci * MeSH
• sportovní výkon MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladiství MeSH
• mladý dospělý MeSH
• ženské pohlaví MeSH

The presented study is focused at identifying the genetic predispositions for anaerobic performance in a group of elite fencers of the Czech Republic. Based on theoretical findings and previous studies, we assume that the identification of genetic coding can help revealing sport talents or recommend to a person interested in sport a suitable branch considering his qualifications. The study concentrates on the comparison of speed-strenght abilities determined by Wingate test performed in the Biomedical laboratory of FTVS at Charles University in Prague and specific speed tests for fencing with R577X polymorphism of ACTN3 gene in elite fencers of the Czech Republic. By the analysis of buccal smear, we found that 80% of our sample of fencers contains in their genotype at least one R allele of the ACTN3 gene of the R577X polymorphism and 27% of the whole are homozygotes with RR genotype.

• MeSH
• dospělí MeSH
• ergometrie statistika a číselné údaje   MeSH
• genetické testování statistika a číselné údaje   MeSH
• genotyp MeSH
• kosterní svaly fyziologie   MeSH
• lidé MeSH
• polymorfismus genetický * genetika   MeSH
• sportovci MeSH
• sportovní výkon * fyziologie   MeSH
• tělesná výkonnost fyziologie   MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• mužské pohlaví MeSH
• Publikační typ
• hodnotící studie MeSH
• práce podpořená grantem MeSH

The α-actinin-3 (ACTN3) gene rs1815739 (C/T, R577X) polymorphism is a variant frequently associated with athletic performance among different populations. However, there is limited research on the impact of this variant on athlete status and physical performance in basketball players. Therefore, the aim of this study was twofold: (1) to determine the association of ACTN3 rs1815739 polymorphism with changes in physical performance in response to six weeks of training in elite basketball players using 30 m sprint and Yo-Yo Intermittent Recovery Test Level 2 (IR 2) tests, and (2) to compare ACTN3 genotype and allelic frequencies between elite basketball players and controls. The study included a total of 363 individuals, comprising 101 elite basketball players and 262 sedentary individuals. Genomic DNA was isolated from oral epithelial cells or leukocytes, and genotyping was performed by real-time PCR using KASP genotyping method or by microarray analysis. We found that the frequency of the ACTN3 rs1815739 XX genotype was significantly lower in basketball players compared to controls (10.9 vs. 21.4%, p = 0.023), suggesting that RR/RX genotypes were more favorable for playing basketball. Statistically significant (p = 0.045) changes were observed in Yo-Yo IRT 2 performance measurement tests in basketball players with the RR genotype only. In conclusion, our findings suggest that the carriage of the ACTN3 rs1815739 R allele may confer an advantage in basketball.

• MeSH
• aktinin * genetika   MeSH
• basketbal * MeSH
• frekvence genu MeSH
• genotyp MeSH
• lidé MeSH
• polymorfismus genetický MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH

• MeSH
• dítě MeSH
• fotbal MeSH
• genotyp MeSH
• jednonukleotidový polymorfismus genetika   MeSH
• kosterní svalová vlákna fyziologie   MeSH
• kosterní svaly fyziologie   MeSH
• lidé MeSH
• nadání klasifikace   MeSH
• pohybová aktivita fyziologie   genetika   MeSH
• sportovní výkon klasifikace   normy   MeSH
• svalová kontrakce fyziologie   MeSH
• Check Tag
• dítě MeSH
• lidé MeSH
• mužské pohlaví MeSH

• Klíčová slova
• V-aktinin, genové varianty, polymorfismus R577X,
• MeSH
• aktinin genetika   MeSH
• alely MeSH
• běh MeSH
• genotyp MeSH
• jednonukleotidový polymorfismus genetika   MeSH
• kosterní svaly MeSH
• lehká atletika MeSH
• lidé MeSH
• tělesná výkonnost MeSH
• Check Tag
• lidé MeSH