Evoked neural responses to sensory stimuli have been extensively investigated in humans and animal models both to enhance our understanding of brain function and to aid in clinical diagnosis of neurological and neuropsychiatric conditions. Recording and imaging techniques such as electroencephalography (EEG), magnetoencephalography (MEG), local field potentials (LFPs), and calcium imaging provide complementary information about different aspects of brain activity at different spatial and temporal scales. Modeling and simulations provide a way to integrate these different types of information to clarify underlying neural mechanisms. In this study, we aimed to shed light on the neural dynamics underlying auditory evoked responses by fitting a rate-based model to LFPs recorded via multi-contact electrodes which simultaneously sampled neural activity across cortical laminae. Recordings included neural population responses to best-frequency (BF) and non-BF tones at four representative sites in primary auditory cortex (A1) of awake monkeys. The model considered major neural populations of excitatory, parvalbumin-expressing (PV), and somatostatin-expressing (SOM) neurons across layers 2/3, 4, and 5/6. Unknown parameters, including the connection strength between the populations, were fitted to the data. Our results revealed similar population dynamics, fitted model parameters, predicted equivalent current dipoles (ECD), tuning curves, and lateral inhibition profiles across recording sites and animals, in spite of quite different extracellular current distributions. We found that PV firing rates were higher in BF than in non-BF responses, mainly due to different strengths of tonotopic thalamic input, whereas SOM firing rates were higher in non-BF than in BF responses due to lateral inhibition. In conclusion, we demonstrate the feasibility of the model-fitting approach in identifying the contributions of cell-type specific population activity to stimulus-evoked LFPs across cortical laminae, providing a foundation for further investigations into the dynamics of neural circuits underlying cortical sensory processing.

• MeSH
• Acoustic Stimulation methods   MeSH
• Electroencephalography methods   MeSH
• Haplorhini MeSH
• Humans MeSH
• Computer Simulation MeSH
• Evoked Potentials, Auditory physiology   MeSH
• Auditory Cortex * physiology   MeSH
• Animals MeSH
• Check Tag
• Humans MeSH
• Animals MeSH
• Publication type
• Journal Article MeSH
• Research Support, N.I.H., Extramural MeSH

Východiská: Využívanie informačno-komunikačných technológií (IKT) je čoraz expanzívnejšie nielen v súvislosti s plnením pracovných či študijných povinností, ale aj vo voľnom čase. IKT je možné vnímať v kontexte rôznych negatívnych dôsledkov na zdravotný a psychický stav človeka. Moderné technológie ako integrálnu súčasť života človeka v súčasnosti je možné využiť aj na podporu a ochranu zdravia. V tejto oblasti majú široké možnosti aj sestry ako najpočetnejšia skupina zdravotníckych pracovníkov.Cieľ: Článok je zameraný na prezentáciu výsledkov výskumu, ktorého cieľom bolo zistiť mieru využívania IKT v dospelej populácii.Metódy: Pre kvantitatívny výskum bol použitý dotazník vlastnej konštrukcie so zameraním na využívanie IKT v dospelej populácii. Súbor tvorilo 142 respondentov vo veku od 18 rokov. Výsledky: Najčastejšie využívané IKT boliuvádzanémobilnýtelefóna notebook. Priemerný čas využívania v pracovnom čase predstavuje 5 hodín. Časový priemer využívania IKT vo voľnom čase je 3,5 hodiny. Najčastejší účel využívania IKT je vyhľadávanie informácií na internete a sociálne siete.Diskusia: IKT čoraz výraznejšie ovplyvňujú mnohé oblasti ľudského života, psychické a fyzické zdravie človeka aj návyky. Zameranie na dospelú populáciu respondentov bolo ovplyvnené tým, že v rámci problému, ktorý bol predmetom skúmania, vedia dospelí ľudia posúdiť vzťah využívania IKT a ich zdravia alebo životného štýlu, sú vzorom deťom a dospievajúcim v oblasti zdravia a zdravotných návykov, participujú na ich výchove, a tiež častejšie oproti mladším vekovým kategóriám vyhľadávajú v tejto súvislosti informácie prostredníctvom IKT. V nadväznosti na získané výsledky sú koncipované intervencie, ktoré je možné implementovať v ošetrovateľskej praxi. Záver: Výskum poukázal na skutočnosti, ktoré je možné využiť aj v odbore ošetrovateľstvo, a to na propagáciu negatívnych dôsledkov nadlimitného využívania IKT v každodennom živote, ale aj na využitie IKT ako prostriedku na ochranu a podporu zdravia a šírenie zdraviu prospešných informácií.

Background: The use of information and communication technologies (ICT) is becoming more and more expansive not only in connection with the fulfillment of work or study obligations, but also in free time. ICT can be perceived in the context of various negative consequences on a person's health and psychological state. Modern technologies, as an integral part of human life nowadays, can also be used to support and protect health. Nurses, as the largest group of healthcare professionals, have wide opportunities in this area.Aim: The article is aimed at presenting the results of a survey, the aim of which was to determine the rate of ICT use in the adult population.Methods: A self-constructed questionnaire focusing on the use of ICT in the adult population was used for quantitative research. The file consisted of 142 respondents aged 18 and over.Results: The most frequently used ICT were a mobile phone and a laptop. The average time of use during working hours is 5 hours. The average time spent using ICT in free time is 3.5 hours. The most common purpose of using ICT is searching for information on the Internet and social networks.Discussion: ICT is increasingly influencing many areas of human life, mental and physical health and habits. The focus on the adult population of respondents was influenced by the fact that, within the framework of the problem that was the subject of research, adults can assess the relationship between the use of ICT and their health or lifestyle, they are role models for children and adolescents in the area of health and health habits, they participate in their education, and they also look for information in this context through ICT more often than younger age groups. Based on the obtained results, interventions are designed that can be implemented in nursing practice.Conclusion: The research pointed to facts that can also be used in the field of nursing, namely to promote the negative consequences of excessive use of ICT in everyday life, but also to use ICT as a means to protect and promote health and spread health- promoting information.

• MeSH
• Adult MeSH
• Information Technology MeSH
• Communications Media MeSH
• Nursing MeSH
• Internet Use * trends   MeSH
• Cell Phone Use * MeSH
• Self Report MeSH
• Check Tag
• Adult MeSH

Dynamics underlying epileptic seizures span multiple scales in space and time, therefore, understanding seizure mechanisms requires identifying the relations between seizure components within and across these scales, together with the analysis of their dynamical repertoire. In this view, mathematical models have been developed, ranging from single neuron to neural population. In this study, we consider a neural mass model able to exactly reproduce the dynamics of heterogeneous spiking neural networks. We combine mathematical modeling with structural information from non invasive brain imaging, thus building large-scale brain network models to explore emergent dynamics and test the clinical hypothesis. We provide a comprehensive study on the effect of external drives on neuronal networks exhibiting multistability, in order to investigate the role played by the neuroanatomical connectivity matrices in shaping the emergent dynamics. In particular, we systematically investigate the conditions under which the network displays a transition from a low activity regime to a high activity state, which we identify with a seizure-like event. This approach allows us to study the biophysical parameters and variables leading to multiple recruitment events at the network level. We further exploit topological network measures in order to explain the differences and the analogies among the subjects and their brain regions, in showing recruitment events at different parameter values. We demonstrate, along with the example of diffusion-weighted magnetic resonance imaging (dMRI) connectomes of 20 healthy subjects and 15 epileptic patients, that individual variations in structural connectivity, when linked with mathematical dynamic models, have the capacity to explain changes in spatiotemporal organization of brain dynamics, as observed in network-based brain disorders. In particular, for epileptic patients, by means of the integration of the clinical hypotheses on the epileptogenic zone (EZ), i.e., the local network where highly synchronous seizures originate, we have identified the sequence of recruitment events and discussed their links with the topological properties of the specific connectomes. The predictions made on the basis of the implemented set of exact mean-field equations turn out to be in line with the clinical pre-surgical evaluation on recruited secondary networks.

• Publication type
• Journal Article MeSH

Východiská: Využívanie informačno-komunikačných technológií (IKT) je čoraz expanzívnejšie nielen v súvislosti s plnením pracovných či študijných povinností, ale aj vo voľnom čase. IKT je možné vnímať v kontexte rôznych negatívnych dôsledkov na zdravotný a psychický stav človeka. Moderné technológie ako integrálnu súčasť života človeka v súčasnosti je možné využiť aj na podporu a ochranu zdravia. V tejto oblasti majú široké možnosti aj sestry ako najpočetnejšia skupina zdravotníckych pracovníkov.Cieľ: Článok je zameraný na prezentáciu výsledkov výskumu, ktorého cieľom bolo zistiť mieru využívania IKT v dospelej populácii.Metódy: Pre kvantitatívny výskum bol použitý dotazník vlastnej konštrukcie so zameraním na využívanie IKT v dospelej populácii. Súbor tvorilo 142 respondentov vo veku od 18 rokov. Výsledky: Najčastejšie využívané IKT boliuvádzanémobilnýtelefóna notebook. Priemerný čas využívania v pracovnom čase predstavuje 5 hodín. Časový priemer využívania IKT vo voľnom čase je 3,5 hodiny. Najčastejší účel využívania IKT je vyhľadávanie informácií na internete a sociálne siete.Diskusia: IKT čoraz výraznejšie ovplyvňujú mnohé oblasti ľudského života, psychické a fyzické zdravie človeka aj návyky. Zameranie na dospelú populáciu respondentov bolo ovplyvnené tým, že v rámci problému, ktorý bol predmetom skúmania, vedia dospelí ľudia posúdiť vzťah využívania IKT a ich zdravia alebo životného štýlu, sú vzorom deťom a dospievajúcim v oblasti zdravia a zdravotných návykov, participujú na ich výchove, a tiež častejšie oproti mladším vekovým kategóriám vyhľadávajú v tejto súvislosti informácie prostredníctvom IKT. V nadväznosti na získané výsledky sú koncipované intervencie, ktoré je možné implementovať v ošetrovateľskej praxi. Záver: Výskum poukázal na skutočnosti, ktoré je možné využiť aj v odbore ošetrovateľstvo, a to na propagáciu negatívnych dôsledkov nadlimitného využívania IKT v každodennom živote, ale aj na využitie IKT ako prostriedku na ochranu a podporu zdravia a šírenie zdraviu prospešných informácií.

Background: The use of information and communication technologies (ICT) is becoming more and more expansive not only in connection with the fulfillment of work or study obligations, but also in free time. ICT can be perceived in the context of various negative consequences on a person's health and psychological state. Modern technologies, as an integral part of human life nowadays, can also be used to support and protect health. Nurses, as the largest group of healthcare professionals, have wide opportunities in this area.Aim: The article is aimed at presenting the results of a survey, the aim of which was to determine the rate of ICT use in the adult population.Methods: A self-constructed questionnaire focusing on the use of ICT in the adult population was used for quantitative research. The file consisted of 142 respondents aged 18 and over.Results: The most frequently used ICT were a mobile phone and a laptop. The average time of use during working hours is 5 hours. The average time spent using ICT in free time is 3.5 hours. The most common purpose of using ICT is searching for information on the Internet and social networks.Discussion: ICT is increasingly influencing many areas of human life, mental and physical health and habits. The focus on the adult population of respondents was influenced by the fact that, within the framework of the problem that was the subject of research, adults can assess the relationship between the use of ICT and their health or lifestyle, they are role models for children and adolescents in the area of health and health habits, they participate in their education, and they also look for information in this context through ICT more often than younger age groups. Based on the obtained results, interventions are designed that can be implemented in nursing practice.Conclusion: The research pointed to facts that can also be used in the field of nursing, namely to promote the negative consequences of excessive use of ICT in everyday life, but also to use ICT as a means to protect and promote health and spread health- promoting information.

• MeSH
• Adult MeSH
• Information Technology MeSH
• Communications Media MeSH
• Nursing MeSH
• Internet Use * MeSH
• Cell Phone Use * MeSH
• Self Report MeSH
• Check Tag
• Adult MeSH

• MeSH
• Sampling Studies MeSH

• Conspectus
• Statistika
• NML Fields
• statistika, zdravotnická statistika

• MeSH
• Biology MeSH
• Publication type
• Monograph MeSH

• Conspectus
• Obecná biologie
• NML Fields
• biologie

• MeSH
• Patient Navigation MeSH
• Disease Management MeSH
• Neoplasms MeSH
• Publication type
• Collected Work MeSH

• Conspectus
• Patologie. Klinická medicína
• NML Fields
• onkologie
• NML Publication type
• brožury

• Keywords
• Biologie, Evoluce, Fylogeneze,
• MeSH
• Biological Evolution MeSH
• Biology MeSH
• Phylogeny MeSH
• Evolution, Molecular MeSH
• Origin of Life MeSH

• Conspectus
• Obecná genetika. Obecná cytogenetika. Evoluce
• NML Fields
• molekulární biologie, molekulární medicína

• MeSH
• Mathematics MeSH
• Statistics as Topic MeSH

• Conspectus
• Statistika
• NML Fields
• statistika, zdravotnická statistika

• MeSH
• Environmental Health MeSH
• Disasters MeSH
• Crisis Intervention MeSH
• Emergencies MeSH
• Relief Work MeSH
• First Aid MeSH

• Conspectus
• Lékařské vědy. Lékařství
• NML Fields
• environmentální vědy
• urgentní lékařství
• environmentální vědy