• MeSH
• analgezie metody   MeSH
• antibiotická profylaxe metody   MeSH
• časné pohybování metody   MeSH
• hydratace organismu MeSH
• hypotermie prevence a kontrola   MeSH
• katetrizace močového měchýře metody   MeSH
• lidé MeSH
• nauzea farmakoterapie   prevence a kontrola   MeSH
• perioperační péče * metody   MeSH
• protézy a implantáty normy   MeSH
• protézy kloubů * normy   trendy   MeSH
• rehabilitace metody   trendy   MeSH
• tromboembolie prevence a kontrola   MeSH
• vzdělávání pacientů jako téma metody   MeSH
• Check Tag
• lidé MeSH

BACKGROUND: Postoperative nausea and vomiting (PONV) is a significant problem following paediatric surgery, and volatile anaesthetics are an important cause of this phenomenon. BIS-guided anaesthesia, by reducing the consumption of anaesthetics, leads to a decrease in PONV in adult patients. STUDY OBJECTIVE: Evaluate the role of BIS-guided anaesthesia in reducing the incidence of paediatric PONV. DESIGN: Prospective, randomized, double-blind study. SETTING: A single center study in university hospital in Czech republic, from June 2021 to November 2022. PATIENTS: A total of 163 children, aged 3-8 years with ASA I-II who underwent endoscopic adenoidectomy under general anaesthesia were included. INTERVENTIONS: In the intervention group, the depth of anaesthesia was maintained to values between 40 and 60 of BIS. MAIN OUTCOME MEASURE: The primary outcome was the incidence of postoperative nausea and vomiting during 24 h after surgery. RESULTS: The use of BIS-guided anaesthesia led to a significant decrease in the incidence of nausea and vomiting compared to the control group [17% vs. 53%; RR (95%CI) 0.48 (0.27-0.86); p < 0.001and 16% vs. 34%; RR (95%CI) 0.33 (0.20-0.54); p = 0.01, respectively]. CONCLUSIONS: BIS-guided anaesthesia decreases the incidence of postoperative nausea and vomiting in children undergoing adenoidectomy. TRIAL REGISTRATION: Clinicaltrials.gov identifier: NCT04466579.

• MeSH
• adenektomie * škodlivé účinky   metody   MeSH
• celková anestezie * metody   škodlivé účinky   MeSH
• dítě MeSH
• dvojitá slepá metoda MeSH
• incidence MeSH
• lidé MeSH
• pooperační nevolnost a zvracení * epidemiologie   prevence a kontrola   MeSH
• předškolní dítě MeSH
• prospektivní studie MeSH
• Check Tag
• dítě MeSH
• lidé MeSH
• mužské pohlaví MeSH
• předškolní dítě MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• randomizované kontrolované studie MeSH
• Geografické názvy
• Česká republika MeSH

Buddhist meditation practices, including Samadhi meditation, which forms the basis for mindfulness practice, are broadly promoted as pathways to wellbeing, but evidence of their adverse effects is emerging. In a single-group observational study with assessments of autonomic system before, during, and after Samadhi meditation, we explore the relationship between post-meditation nausea symptoms and the degree of change in autonomic system activity during meditation as compared to before and after in 57 university students (42 women; mean age = 22.6) without any previous experience in meditation or yoga practices. We hypothesize that nauseous feelings in meditation are connected to a rapid increase of activity in the sympathetic nervous system, as indicated by decreased heart-rate variability (HRV). We additionally explore links between meditation-induced nausea and two markers of parasympathetic activity: increased HRV and vasovagal syncope. Engaging in meditation and increased nausea during meditation were both associated with increased markers of HRV parasympathetic activity, but 12 individuals with markedly higher nausea demonstrated increased HRV markers of sympathetic activity during meditation. Vasovagal syncope was observed but found to be unrelated to nausea levels. Drivers of adverse effects of meditation in some individuals require further investigation.

• MeSH
• autonomní nervový systém * fyziologie   patofyziologie   MeSH
• dospělí MeSH
• lidé MeSH
• meditace * psychologie   MeSH
• mladý dospělý MeSH
• nauzea * psychologie   MeSH
• srdeční frekvence * fyziologie   MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• mladý dospělý MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• pozorovací studie MeSH
• Geografické názvy
• Česká republika MeSH

INTRODUCTION: The non-intoxicating plant-derived cannabinoid, cannabidiol (CBD), has demonstrated therapeutic potential in a number of clinical conditions. Most successful clinical trials have used relatively high (≥300 mg) oral doses of CBD. Relatively few studies have investigated the efficacy of lower (<300 mg) oral doses, typical of those available in over-the-counter CBD products. METHODS: We present a protocol for a randomised, double-blind, placebo-controlled, parallel-group clinical trial investigating the effects of a low oral dose (150 mg) of CBD on acute psychosocial stress, situational anxiety, motion sickness and cybersickness in healthy individuals. Participants (n=74) will receive 150 mg of CBD or a matched placebo 90 min before completing three virtual reality (VR) challenges (tasks) designed to induce transient stress and motion sickness: (a) a 15 min 'Public Speaking' task; (b) a 5 min 'Walk the Plank' task (above a sheer drop); and (c) a 5 min 'Rollercoaster Ride' task. The primary outcomes will be self-reported stress and nausea measured on 100 mm Visual Analogue Scales. Secondary outcomes will include salivary cortisol concentrations, skin conductance, heart rate and vomiting episodes (if any). Statistical analyses will test the hypothesis that CBD reduces nausea and attenuates subjective, endocrine and physiological responses to stress compared with placebo. This study will indicate whether low-dose oral CBD has positive effects in reducing acute psychosocial stress, situational anxiety, motion sickness and cybersickness. ETHICS AND DISSEMINATION: The University of Sydney Human Research Ethics Committee has granted approval (2023/307, version 1.6, 16 February 2024). Study findings will be disseminated in a peer-reviewed journal and at academic conferences. TRIAL REGISTRATION NUMBER: Australian New Zealand Clinical Trials Registry (ACTRN12623000872639).

• MeSH
• dvojitá slepá metoda MeSH
• kanabidiol * terapeutické užití   MeSH
• kinetózy * farmakoterapie   MeSH
• lidé MeSH
• nauzea farmakoterapie   MeSH
• psychický stres MeSH
• randomizované kontrolované studie jako téma MeSH
• úzkost farmakoterapie   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• protokol klinické studie MeSH
• Geografické názvy
• Austrálie MeSH

Aim: This study aims to assess the effectiveness of ATHP-HC on the severity of nausea and vomiting, relaxation state, brainwaves, and quality of life in women with Nausea and Vomiting in Pregnancy (NVP). Methods: A quasi-experimental study was conducted on 62 pregnant women randomly allocated into intervention and control groups using a pre-post-test. Researchers provided ATHP-HC to the intervention group and Cirebon Gamelan audio therapy to the control group. The research instruments included PUQE-24-hour scoring, measurement of vital signs, brainwaves using NeuroSky MindWave Mobile II, and WHOQOL-BREF. The data collected were processed with SPSS version 24.0 and analyzed using the statistical formula paired t-test. Results: The results of the study showed that there were significant differences between nausea and vomiting scores (p = 0.000), relaxation levels (p = 0.003 in the intervention group and p = 0.000 in the control group), and quality of life (p = 0.000), before and after the treatment in the intervention group and the control group. There was a significant difference in the state of relaxation after the intervention in the two groups of respondents (p = 0.001). There was no significant difference in the proportion of increased meditation in the two groups of respondents (p = 0.707). Conclusion: As relaxation and meditation music, ATHP-HC can be a complementary therapy for pregnant women to overcome NVP.

• MeSH
• kvalita života MeSH
• lidé MeSH
• mozkové vlny MeSH
• muzikoterapie * metody   MeSH
• nauzea terapie   MeSH
• nervový systém - fyziologické jevy MeSH
• průzkumy a dotazníky MeSH
• relaxace MeSH
• statistika jako téma MeSH
• těhotenství * MeSH
• zvracení terapie   MeSH
• Check Tag
• lidé MeSH
• těhotenství * MeSH
• ženské pohlaví MeSH
• Publikační typ
• klinická studie MeSH

Cieľ: Zamerali sme sa na anestéziu a jej vplyv na psychické rozpoloženie pacientov. Dizajn: Sledovali sme vzťah medzi výskytom nepríjemných zážitkov pacientov počas anestézie a demografickými údajmi. Metódy: Súbor tvorilo 219 pacientov po anestézii. Pre interpretáciu výsledkov sme vypočítali jednoduché frekvencie, percentuálne hodnotenie súboru, aritmetický priemer, medián a modus. Dotazníky sme pacientom administrovali v Univerzitnej nemocnici Bratislava od novembra 2010 do marca 2011. Výsledky: Najdôležitejšími výsledkami je zistenie vzťahu medzi jednotlivými nepríjemnými zážitkami a vekom pacientov, kde sme štatistickú významnosť zistili u nepríjemných zážitkov, ako je spomienka bez bolesti (p = 0,015), vracanie (p = 0,029), svalová slabosť (p = 0,048) a bolesť hlavy (p = 0,015); a pri hodnotení vzťahu medzi výskytom nepríjemných zážitkov a pohlavím, kde sme zistili štatisticky významný vzťah vo výskyte nevoľnosti (p = 0,000), problémov s dýchaním (p = 0,048), vracaním (p = 0,015), bolesti v operačnej rane (p = 0,001) a svalovej slabosti (p = 0,003). Záver: Výsledky potvrdzujú vzťah medzi výskytom nepríjemných zážitkov pacientov počas anestézie a ich demografickými údajmi. Na základe našich zistení navrhujeme vytvorenie protokolov predoperačnej prípravy so zameraním sa na identifikáciu najčastejších nepríjemných zážitkov u pacientov súvisiacich s anestéziou.

Purpose: We focused on anaesthesia and its impact on patients' mental mood. Design: We followed the relationship between the occurrence of unpleasant experiences of patients during anaesthesia and demographic data. Methods: The group consisted of 219 patients after anaesthesia. We administered questionnaires to patients at the University Hospital Bratislava between November 2010 and March 2011. Results: The most important results are the subsequent investigation of the relationship between individual unpleasant experiences and the age of the patients, where we found statistical significance in unpleasant experiences such as recall without pain (p = 0.015), vomiting (p = 0.029), muscle weakness (p = 0.048), and headache (p = 0.015); and when evaluating the relationship between the incidence of unpleasant experiences and sex, we found a statistically significant relationship in the incidence of nausea (p = 0.000), breathing problems (p = 0.048), vomiting (p = 0.015), pain in the surgical wound (p = 0.001), and muscle weakness (p = 0.003). Conclusion: Results confirm the relationship between the occurrence of unpleasant experiences of patients during anaesthesia and their demographic data. Based on our findings, we propose creating protocols for preoperative preparation, focusing on identifying the most common unpleasant experiences in patients related to anaesthesia.

• MeSH
• anestezie * psychologie   škodlivé účinky   MeSH
• dospělí MeSH
• dyspnoe etiologie   MeSH
• emoce * účinky léků   MeSH
• lidé MeSH
• nauzea * etiologie   MeSH
• pooperační bolest etiologie   komplikace   MeSH
• senioři MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH

Pooperační nevolnost a zvracení (PONV) je častou pooperační komplikací, která postihuje 20-30 % dětí, u vysoce rizikových výkonů stoupá incidence až k 80 %. PONV vedle subjektivního dyskomfortu zvyšuje pooperační morbiditu a ohrožuje dítě dehydratací, dehiscencí operační rány a následným krvácením. Dochází k prodloužení pobytu na dospávacím pokoji a celkové doby hospitalizace. Management PONV spočívá v identifikaci rizikových pacientů a zahájení adekvátní prevence. Lékem volby je dexametazon nebo ondansetron, u vysoce rizikových dětí jejich kombinace. V případě selhání prevence je indikace k podání antiemetika z jiné farmakologické skupiny.

Postoperative nausea and vomiting (PONV) is a common postoperative complication with overall incidence of 20-30 %, however, with high risk procedures it increases up to 80 %. PONV is the main cause of the patient ́s discomfort, worsens perioperative morbidity and put the child at risk of dehydratation, dehiscence of surgical wound and bleeding. PONV prolongs the lenght of stay (PACU, in-hospital care). The cornerstone of PONV management is the identification of high risk pediatric patients and an adequate pre-operative pharmacological prevention. Dexamethasone and ondansetron (or their combination) are the first line medications. In case of failure, rescue therapy should be provided with other pharmacological agents.

• MeSH
• antiemetika MeSH
• dexamethason aplikace a dávkování   terapeutické užití   MeSH
• dítě MeSH
• lidé MeSH
• ondansetron aplikace a dávkování   terapeutické užití   MeSH
• pooperační nevolnost a zvracení * diagnóza   farmakoterapie   prevence a kontrola   MeSH
• rizikové faktory MeSH
• Check Tag
• dítě MeSH
• lidé MeSH
• Publikační typ
• přehledy MeSH

• MeSH
• antiemetika farmakologie   terapeutické užití   MeSH
• kombinovaná farmakoterapie metody   MeSH
• lidé MeSH
• nauzea diagnóza   farmakoterapie   MeSH
• off-label použití léčivého přípravku MeSH
• olanzapin * aplikace a dávkování   farmakologie   terapeutické užití   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• přehledy MeSH

This is the primary report of the randomized, placebo-controlled phase 3 BRIGHT AML 1019 clinical trial of glasdegib in combination with intensive chemotherapy (cytarabine and daunorubicin) or non-intensive chemotherapy (azacitidine) in patients with untreated acute myeloid leukemia. Overall survival (primary endpoint) was similar between the glasdegib and placebo arms in the intensive (n = 404; hazard ratio [HR] 1.05; 95% confidence interval [CI]: 0.782-1.408; two-sided p = 0.749) and non-intensive (n = 325; HR 0.99; 95% CI: 0.768-1.289; two-sided p = 0.969) studies. The proportion of patients who experienced treatment-emergent adverse events was similar for glasdegib versus placebo (intensive: 99.0% vs. 98.5%; non-intensive: 99.4% vs. 98.8%). The most common treatment-emergent adverse events were nausea, febrile neutropenia, and anemia in the intensive study and anemia, constipation, and nausea in the non-intensive study. The addition of glasdegib to either cytarabine and daunorubicin or azacitidine did not significantly improve overall survival and the primary efficacy endpoint for the BRIGHT AML 1019 phase 3 trial was not met. Clinical trial registration: ClinicalTrials.gov: NCT03416179.

• MeSH
• akutní myeloidní leukemie * MeSH
• anemie * farmakoterapie   MeSH
• azacytidin terapeutické užití   MeSH
• cytarabin MeSH
• daunomycin MeSH
• lidé MeSH
• nauzea farmakoterapie   MeSH
• protokoly protinádorové kombinované chemoterapie škodlivé účinky   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• klinické zkoušky, fáze III MeSH
• randomizované kontrolované studie MeSH

Postdischarge nausea and vomiting (PDNV) cause substantial pediatric morbidity with potentially serious postoperative complications. However, few studies have addressed PDNV prevention and treatment in pediatric patients. Here we searched the literature and processed it in a narrative review describing PDNV incidence, risk factors, and management in pediatric patients.. A successful strategy for reducing PDNV considers both the pharmacokinetics of the antiemetic agents and the principle of multimodal prophylaxis, utilizing agents of different pharmacologic classes. Since many highly effective antiemetic agents have relatively short half-lives, a different approach must be used to prevent PDNV. A combination of oral and intravenous medications with longer half-lives, such as palonosetron or aprepitant, can be used. In addition, we designed a prospective observational study with the primary objective of determining PDNV incidence. In our study group of 205 children, the overall PDNV incidence was 14.6% (30 of 205), including 21 children suffering from nausea and 9 suffering from vomiting.

• MeSH
• antiemetika * terapeutické užití   MeSH
• dítě MeSH
• lidé MeSH
• následná péče MeSH
• pooperační nevolnost a zvracení prevence a kontrola   farmakoterapie   MeSH
• pozorovací studie jako téma MeSH
• propuštění pacienta MeSH
• prospektivní studie MeSH
• Check Tag
• dítě MeSH
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH