Cancer is still one of the leading causes of death, with an estimated 19.3 million new cases every year. Our paper presents the tumor-suppressing effect of Taenia crassiceps and Mesocestoides corti on B16F10 melanoma, the intraperitoneal application of which followed the experimental infection with these tapeworms, resulting in varying degrees of effectiveness in two strains of mice. In the case of M. corti-infected ICR mice, a strong tumor growth suppression occurred, which was accompanied by a significant reduction in the formation of distant metastases in the liver and lung. Tapeworm-infected C57BL/6J mice also showed a suppression of tumor growth and, in addition, the overall survival of infected C57BL/6J mice was significantly improved. Experiments with potential cross-reaction of melanoma and tapeworm antigens with respective specific antibodies, restimulation of spleen T cells, or the direct effect of tapeworm excretory-secretory products on melanoma cells in vitro could not explain the phenomenon. However, infections with T. crassiceps and M. corti increased the number of leukocytes possibly involved in anti-tumor immunity in the peritoneal cavity of both ICR and C57BL/6J mice. This study unveils the complex interplay between tapeworm infections, immune responses, and melanoma progression, emphasizing the need for further exploration of the mechanisms driving observed tumor-suppressive effects.
- MeSH
- Cestoda * MeSH
- cestodózy * komplikace patologie MeSH
- melanom * komplikace MeSH
- Mesocestoides * fyziologie MeSH
- myši inbrední C57BL MeSH
- myši inbrední ICR MeSH
- myši MeSH
- Taenia * MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- MeSH
- kontaminace potravin MeSH
- lidé MeSH
- paraziti * MeSH
- Taenia MeSH
- Trichinella MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- přehledy MeSH
Kočka patří k nejstarším domestikovaným zvířatům žijícím vedle člověka již několik tisíciletí. Ve spektru endoparazitů u domácích koček dominují druhy parazitů s heteroxenním vývojovým cyklem adaptovaným na vztah mezi predátorem a jeho kořistí. Poznání tasemnic v populacích koček v ÈR zásadně ovlivňuje to, že data z toulavých, městských nebo „outdoorových“ koček je obtížné vůbec získat. Představy o parazitofauně českých koček tak pochází především z vyšetřování koček typicky domácích, kde je výskyt heteroxenních parazitů velmi nízký. Tasemnice koček v ÈR zahrnují především Taenia taeniaeformis a Dipylidium caninum; alarmující je ale riziko možného zapojení kočky do cyklu E. multilocularis, vyvolávající významné orgánové infekce člověka. Odpověď na otázku, jak významným rezervoárem tasemnice Echinococcus multilocularis kočka je, zasluhuje v ÈR intenzivní výzkum.
Cats belong among the oldest domesticated animals, living side by side with humans for several millennia. Spectrum of endoparasites of domestic cats is dominated by parasites with heteroxenous life cycles, cycling among the predators and their prey. Knowledge on tapeworms in cats in Czechia is influenced by a fact, that data from street, stray or feral cats are difficult to obtain. Our knowledge thus originates mostly from indoor cats, where the occurrence of heteroxenous parasites is very low. Most frequently detected tapeworms in cats are Taenia taeniaeformis and Dipylidium caninum. However, there is an alarming risk of involvement of cats in the life cycle of Echinococcus multilocularis, causing severe organ echinococcosis in humans. Yet, answer to the question of the importance of cats as a reservoir of E. multilocularis in Czechia requires intense research.
- MeSH
- albendazol terapeutické užití MeSH
- dospělí MeSH
- klinické laboratorní techniky MeSH
- lidé MeSH
- neurocysticercosis * diagnóza terapie MeSH
- neurozobrazování metody MeSH
- Taenia solium izolace a purifikace účinky léků MeSH
- výsledek terapie MeSH
- záchvaty diagnóza etiologie terapie MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- ženské pohlaví MeSH
- Publikační typ
- kazuistiky MeSH
Taeniosis-cysticercosis caused by Taenia crassiceps (Zeder, 1800) is a useful experimental model for biomedical research, in substitution of Taenia solium Linnaeus, 1758, studied during decades to develop effective vaccination, novel anti-helminthic drugs and diagnostic tools. Cysticercosis in mouse (Mus musculus Linnaeus) is achieved by the larval subculturing of the Wake Forest University (WFU) strain of T. crassiceps. Golden hamster, Mesocricetus auratus (Waterhouse), has been shown to be the most suitable host for adult forms of parasite in experimental taeniosis. Metacestodes of T. crassiceps WFU multiply by budding without restrictions once inoculated into the mouse, while the number of tapeworms developed from these larvae in hamsters remains highly variable. Three objectives have been proposed to improve the infection of T. crassiceps WFU in hamsters: (1) to re-evaluate the need of immune suppression; (2) to investigate the advantage of infecting hamsters with metacestodes with in vitro protruded scolices; and (3) to compare a number of tapeworms developed from metacestodes subcultured in hamsters against those proliferated in mice. Our results demonstrated that when the evagination of murine metacestodes was high, the number of T. crassiceps WFU adults obtained from hamsters was also high. Immunosuppressive treatment remains relevant for this experimental rodent model. The hamster-to-hamster cysticercosis-taeniosis by T. crassiceps overcame the mouse-to-hamster model in the yield of adult specimens. In vitro scolex evagination and metacestode asexual proliferation in hamsters place this rodent model by T. crassiceps WFU as the most affordable experimental models with taeniids.
- MeSH
- cysticercus fyziologie růst a vývoj MeSH
- cysticerkóza * MeSH
- imunosupresivní léčba * MeSH
- křeček rodu Mesocricetus MeSH
- myši inbrední BALB C MeSH
- myši MeSH
- nemoci hlodavců * imunologie patofyziologie MeSH
- Taenia * fyziologie růst a vývoj MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
BACKGROUND: Taenia solium and Taenia saginata are food-borne parasites of global importance. In eastern Europe only fragmented information is available on the epidemiology of these zoonotic parasites in humans and animal populations. In particular for T. solium, on-going transmission is suspected. The aim of this systematic review was to collect the available data and describe the current knowledge on the epidemiology of T. solium and T. saginata in eastern Europe. METHODS: Literature published in international databases from 1990 to 2017 was systematically reviewed. Furthermore, local sources and unpublished data from national databases were retrieved from local eastern European experts. The study area included 22 countries. RESULTS: Researchers from 18 out of the 22 countries provided data from local and unpublished sources, while no contacts could be established with researchers from Belarus, Kosovo, Malta and Ukraine. Taeniosis and human cysticercosis cases were reported in 14 and 15 out of the 22 countries, respectively. Estonia, the Former Yugoslav Republic of Macedonia, Lithuania, Moldova, Poland, Romania, Serbia, and Slovakia reported cases of porcine cysticercosis. Croatia, Czech Republic, Estonia, Former Yugoslav Republic of Macedonia, Moldova, Poland, Romania, Serbia, Slovakia, and Ukraine reported bovine cysticercosis. CONCLUSIONS: There is indication that taeniosis and cysticercosis are present across eastern Europe but information on the occurrence of T. solium and T. saginata across the region remains incomplete. Available data are scarce and species identification is in most cases absent. Given the public health impact of T. solium and the potential economic and trade implications due to T. saginata, notification of taeniosis and human cysticercosis should be implemented and surveillance and notification systems in animals should be improved.
- MeSH
- cysticerkóza epidemiologie parazitologie MeSH
- lidé MeSH
- nemoci prasat epidemiologie parazitologie MeSH
- nemoci skotu epidemiologie parazitologie MeSH
- neurocysticercosis epidemiologie parazitologie MeSH
- prasata parazitologie MeSH
- prevalence MeSH
- skot MeSH
- Taenia saginata fyziologie MeSH
- Taenia solium fyziologie MeSH
- tenióza epidemiologie parazitologie MeSH
- veřejné zdravotnictví MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- skot MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
- Geografické názvy
- východní Evropa epidemiologie MeSH
- Klíčová slova
- Taenia crassiceps,
- MeSH
- cysticerkóza * chirurgie diagnóza genetika parazitologie veterinární MeSH
- fatální výsledek MeSH
- Galagidae parazitologie MeSH
- nemoci psů * MeSH
- neurocysticercosis etiologie MeSH
- psi parazitologie MeSH
- sekvenční analýza DNA veterinární MeSH
- syndromy imunologické nedostatečnosti parazitologie MeSH
- Taenia * parazitologie patogenita růst a vývoj MeSH
- tenióza * diagnóza genetika parazitologie veterinární MeSH
- zvířata MeSH
- Check Tag
- psi parazitologie MeSH
- zvířata MeSH
- Publikační typ
- kazuistiky MeSH
- Geografické názvy
- Česká republika MeSH
- MeSH
- bezpečnost potravin MeSH
- kontaminace potravin * MeSH
- látky znečišťující půdu MeSH
- lidé MeSH
- maso parazitologie MeSH
- nakládání s odpady MeSH
- odpadní vody * parazitologie MeSH
- potravinářská parazitologie MeSH
- skot MeSH
- Taenia saginata izolace a purifikace parazitologie MeSH
- tenióza * diagnóza epidemiologie prevence a kontrola přenos MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- skot MeSH
- zvířata MeSH
- Geografické názvy
- Česká republika MeSH
- MeSH
- dítě MeSH
- dospělí MeSH
- lidé MeSH
- maso * MeSH
- parazitární nemoci MeSH
- prasata MeSH
- řízení kvality * MeSH
- směrnice jako téma MeSH
- Taenia saginata patogenita MeSH
- Taenia solium patogenita MeSH
- tenióza * diagnóza etiologie prevence a kontrola terapie MeSH
- Trichinella spiralis MeSH
- trichinelóza * diagnóza prevence a kontrola terapie MeSH
- zvířata MeSH
- Check Tag
- dítě MeSH
- dospělí MeSH
- lidé MeSH
- zvířata MeSH
