The cranial window technique has proven to be an effective method for in vivo imaging of cortical activity. However, given the invasive nature of this procedure, possible side effects could be expected in the nervous system. In this study, we evaluated the effects of unilateral cranial window surgery on auditory function in C57BL6 mice using electrophysiological and behavioral approaches. We found that one week after implantation, mice exhibited both increased thresholds and decreased amplitudes of their auditory brainstem responses. These changes were accompanied by a decrease in distortion product otoacoustic emissions, indicating a deterioration in cochlear function. In addition, behavioral testing of these mice revealed reduced suppression of their acoustic startle response by gap prepulse, suggesting a deficit in auditory processing or possibly the presence of tinnitus. The changes in auditory function appeared to be only partially reversible within four weeks after surgery. Thus, our findings suggest that cranial window implantation causes long-term functional changes in the auditory system that should be considered when interpreting data from optical imaging techniques.
Swept-sines provide a tool for fast and high-resolution measurement of evoked otoacoustic emissions. During the measurement, a response to swept-sine(s) is recorded by a probe placed in the ear canal. Otoacoustic emissions can then be extracted by various techniques, e.g., Fourier analysis, the heterodyne method, and the least-square-fitting (LSF) technique. This paper employs a technique originally proposed with exponential swept-sines, which allows for direct emission extraction from the measured intermodulation impulse response. It is shown here that the technique can be used to extract distortion-product otoacoustic emissions (DPOAEs) evoked with two simultaneous swept-sines. For proper extraction of the DPOAE phase, the technique employs previously proposed adjusted formulas for exponential swept-sines generating so-called synchronized swept-sines (SSSs). Here, the SSS technique is verified using responses derived from a numerical solution of a cochlear model and responses measured in human subjects. Although computationally much less demanding, the technique yields comparable results to those obtained by the LSF technique, which has been shown in the literature to be the most noise-robust among the emission extraction methods.
- MeSH
- Fourierova analýza MeSH
- kochlea * fyziologie MeSH
- lidé MeSH
- otoakustické emise spontánní * fyziologie MeSH
- zvukovod fyziologie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
PURPOSE: This study aimed to determine hearing thresholds in an otologically normal population without occupational noise exposure aged 18 to 64 years using extended high-frequency audiometry (EHFA). METHODS: Individuals from the general population who have never had hearing problems and whose job was not associated with noise exposure were included in the study and classified by age into 5 categories: 18-24 and, further, by 10 years of age. Each of these groups was further divided according to gender. All subjects underwent tympanometry, conventional pure-tone audiometry within the 0.125-8 kHz range, and extended high-frequency audiometry within the 9-16 kHz range, performed according to the standards. The significance level for statistical testing was set at 5%. RESULTS: Here, we established hearing thresholds in an otologically healthy population within the extended high-frequency (EHF) range (9-16 kHz). We found the EHFA to be a highly sensitive method for early detection of hearing loss, with hearing thresholds decreasing as soon as 35 years of age. In males, the hearing thresholds grew with age more rapidly than in women. The ability to respond at EHF gradually decreased with age and increasing frequency. CONCLUSION: Our results can help improve the knowledge of EHF hearing thresholds for individual sexes and age groups. So far, the standard 7029:2017 is not binding and, moreover, it only reaches up to the frequency of 12.5 kHz. EHFA is a highly sensitive method for the evaluation of hearing loss depending on age and sex.
- MeSH
- akustické impedanční testy MeSH
- audiometrie čistými tóny MeSH
- audiometrie MeSH
- dítě MeSH
- dospělí MeSH
- hluchota * MeSH
- lidé MeSH
- nedoslýchavost z hluku * diagnóza MeSH
- nedoslýchavost * diagnóza MeSH
- sluch MeSH
- sluchový práh MeSH
- Check Tag
- dítě MeSH
- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- MeSH
- deprese farmakoterapie MeSH
- extrakt z ginkgo aplikace a dávkování MeSH
- Ginkgo biloba * MeSH
- kardiovaskulární systém účinky léků MeSH
- kombinovaná farmakoterapie MeSH
- léková kontraindikace MeSH
- listy rostlin MeSH
- nemoci mozku farmakoterapie MeSH
- sluch účinky léků MeSH
- terapeutické užití MeSH
- zrak účinky léků MeSH
- Publikační typ
- populární práce MeSH
INTRODUCTION: Currently, it is possible to preserve the auditory nerve in a large number of cases, but the preservation of the hearing itself is unpredictable. Apart from wait and scan strategy and stereoradiotherapy, hearing after vestibular schwannoma surgery is considered to remain stable even in long-term follow-up. MATERIALS AND METHODS: Twenty-eight patients had preserved hearing after retrosigmoid suboccipital microsurgery of the vestibular schwannoma between 2008 and 2014. A standard audiological protocol was performed together with an magnetic resonance imaging evaluation of the fluid content of the inner ear. RESULTS: The mean difference in pure-tone average between the direct and final postsurgical examination was 12.758 dB ( p = 2.5E - 06). The word recognition score deteriorated by 17.45% ( p = 0.03516). The mean American Academy of Otolaryngology-Head and Neck Surgery score on the second examination was 2.5, and that on the second examination was 3.111 ( p = 0.00483). There was no significant deterioration in the healthy ear.The signal intensity ratio in the basal turn of the cochlea increased by an average of 0.13 points ( p < 0.05).Patients with persistent tumor or nodular enhancement in the internal acoustic meatus deteriorated significantly in hearing according to the American Academy of Otolaryngology-Head and Neck Surgery scale compared with patients without any finding in the meatus ( p = 0.01299). CONCLUSIONS: There is a discrete but gradual deterioration of the hearing in the postoperative period. Hearing impairment is more pronounced in patients with a nodular process in the internal acoustic meatus, regardless of whether it is growth active. After surgery, the pathological content of the inner ear normalizes (evaluated on T2 magnetic resonance imaging sequences).
- MeSH
- kochlea MeSH
- lidé MeSH
- nedoslýchavost * etiologie MeSH
- retrospektivní studie MeSH
- sluch MeSH
- vestibulární schwannom * chirurgie MeSH
- vnitřní ucho * chirurgie MeSH
- výsledek terapie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
Správná funkčnost screeningu sluchových vad je založena na jednoduché organizaci screeningu, komfortu vyšetření pro pacienta, medicínské výtěžnosti a ekonomické únosnosti. Screening sluchu novorozenců byl aktualizován Metodickým pokynem Ministerstva zdravotnictví České republiky (Věstník MZ ČR č.14/2021). Ke screeningu sluchu fyziologických novorozenců se používají tranzientně evokované otoakustické emise (TEOAE) a u rizikových novorozenců automatické kmenové sluchové potenciály (AABR) a kmenové sluchové potenciály (BERA). Pozitivní screening znamená záchyt sluchové vady (trvalé poruchy sluchu), negativní screening nepřítomnost poruchy sluchu, tj. TEOAE nebo AABR jsou v normě. Cílem práce je podat informace o celostátní databázi a současné metodice screeningu sluchu novorozenců v České republice. Metodika a výsledky: systém včasného záchytu, diagnostiky a korekce sluchu (early hearing detection and intervention, EHDI) je v ČR prováděn na třech úrovních: 1. screening na neonatologických pracovištích, 2. rescreening na ORL nebo foniatrických pracovištích a 3. stanovení sluchového prahu a korekce sluchu v regionálních pedaudiologických pracovištích. Jsou demonstrovány výsledky celostátní databáze, je patrný postupný nárůst počtu screeningu sluchu novorozenců v ČR. Dále je uvedena současná metodika dle Věstníku MZ ČR a připravovaná aktualizace celostátního registru. Diskuse a závěry: díky úzké spolupráci ORL lékařů s neonatology a pediatry byla provedena aktualizace metodického pokynu Ministerstva zdravotnictví České republiky z roku 2012 (Věstník MZ ČR č.7/2012) a vydán nový metodický pokyn ve Věstníku MZ ČR č.14/2021. Harmonogram screeningu a rehabilitace sluchu novorozenců doporučuje následující kroky: 1. screening sluchu fyziologického novorozence v průběhu hospitalizace, nejlépe 2.–3. den po porodu neonatologickou sestrou pomocí otoakustických emisí, u rizikového novorozence je doporučeno použít AABR; 2. rescreening sluchu ve 3.–6. týdnu věku na ORL rescreeningovém pracovišti; 3. dokončení diagnostiky poruchy sluchu do 3.–6. měsíce věku v ORL regionálním (krajském) pedaudiologickém centru.
Screening of hearing loss in newborns is based on simple organization, comfortable examination, effective measurement, and acceptable price. The amendment of Newborn hearing screening guidelines by Ministry of Health of the Czech Republic was published in Bulletin of Ministry of Health of the Czech Republic no. 14/2021. Transient evoked otoacoustic emissions (TEOAE) are used for the screening of normal newborns. Automatic auditory brainstem responses (AABR/BERA) are used for screening of high-risk newborns. `Positive screening` stands for new diagnosed (permanent) hearing loss, `negative screening` stands for normal results of TEOAE or AABR in both ears. The goal of this paper is to provide information about the national database and current methods of newborn hearing screening in the Czech Republic. Methods and results: the system of Early Hearing Detection and Intervention (EHDI) currently carried out in the Czech Republic consists of three levels: screening in neonatal units, rescreening in specialized ENT departments or phoniatric departments and assessment of hearing threshold in regional ENT pedaudiology centers. The results from the national database are presented in this work. Progressive increase in numbers of screening examinations is demonstrated. Further an overview of current methods and planning of a new national registry for newborn hearing screening is presented. Discussion: the amendment of Newborn screening guidelines (originally from 2012) was written in 2021 as a result of close cooperation between ENT, neonatologists and pediatrists. The system of screening follows these steps: 1. screening of hearing in normal newborns during first 3 days of life in hospital by neonatal nurses with TEOAE or with AABR/BERA in high-risk newborns; 2. rescreening of hearing between 3–6 weeks of life in ENT department specialized for re-screening of hearing; 3. final diagnosis of hearing loss up to 6 months of life in regional ENT pedaudiology center.
- MeSH
- lidé MeSH
- novorozenec MeSH
- novorozenecký screening * MeSH
- otoakustické emise spontánní MeSH
- plošný screening statistika a číselné údaje MeSH
- poruchy sluchu * diagnóza prevence a kontrola MeSH
- Check Tag
- lidé MeSH
- novorozenec MeSH
- Publikační typ
- přehledy MeSH
- Geografické názvy
- Česká republika MeSH
OBJECTIVES: Hearing preservation after vestibular schwannoma (VS) surgery remains a surgical challenge. In some patients with preserved inner ear function, hearing improvement is achievable. As it is currently impossible to determine which patients will present this outcome, predictions must rely on previously published reports. Our case report describes a patient who experienced hearing improvement from an unuseful level to a useful one after vestibular schwannoma surgery. METHODS: Surgery was performed via suboccipital retrosigmoid approach. The patient underwent a basic audiovestibular protocol before and after the surgery - pure tone and speech audiometry, otoacoustic emissions, auditory brainstem responses, electronystagmography - together with a detailed questionnaire study. Usefulness of hearing was evaluated using the AAO-HNS guidelines, supplemented by a frequency of 4 kHz. RESULTS: Hearing was preserved and even improved from an unuseful level to a useful one. Based on the available literature, the most informative predictive factors for such a result seem to be: sudden sensorineural hearing loss prior to surgery, elicitable otoacoustic emissions and the origin from the superior vestibular nerve. CONCLUSION: There are a limited number of studies on this topic and it is still impossible to regularly improve hearing in properly selected patients. Furthermore, the importance of postoperative hearing quality compared to other symptoms and complications remains debatable.
- MeSH
- audiometrie čistými tóny MeSH
- lidé MeSH
- retrospektivní studie MeSH
- sluch fyziologie MeSH
- vestibulární schwannom * komplikace chirurgie MeSH
- výsledek terapie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- kazuistiky MeSH
- přehledy MeSH
PURPOSE: The study aimed to evaluate audiological benefits, quality of hearing and safety of two Bonebridge generation: BCI601 and BCI602 (MED-EL, Innsbruck, Austria) in children. METHODS: Twelve children were implanted: five BCI601 and seven BCI602 comprising of ten conductive hearing loss, and two single sided deaf SSD subjects. Audiological outcomes tested were sound field audiometry, functional gain, speech recognition threshold (SRT50), speech recognition in noise (SPRINT) and localisation abilities. Subjective measures were Speech, Spatial and Qualities of Hearing Scale (SSQ12). RESULTS: The mean FG with the BCI601 was 25.0 dB and with the BCI602 28.0 dB. The benefit in SRT50 was 23.2 dB and 33.8 dB, respectively. The mean benefit in SPRINT was 15% and 6.7% and the localisation ability improved from 33.3° to 16° and from 26.2° to 17.6°, respectively. The two SSD subjects reported a FG of 17 dB, a benefit in SRT50 of 22.5 and a benefit in SPRINT of 20%. Subjective outcomes improved significantly and even exceeded the values of their age-and sex matched normal hearing peers. One revision was reported: a retroauricular emphysema above the implant occurred 12 months post-OP, it was resolved operatively with the implant still being functional. CONCLUSION: The pediatric cohort reports significant audiological benefit, even exceeding that of the age- and sex matched control. The combination of the high safety and audiological benefit makes the Bonebridge a comfortable and effective option in hearing rehabilitation in children.
- MeSH
- dítě MeSH
- kostní vedení zvuku MeSH
- lidé MeSH
- percepce řeči * MeSH
- převodní nedoslýchavost chirurgie MeSH
- sluch MeSH
- sluchové pomůcky * MeSH
- sluchové testy MeSH
- výsledek terapie MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
