Urinary galactosyl hydroxylysine/creatinine ratio (GHL) was used to assess rates of bone collagen degradation and the activity of the pagetic lesion as well as for monitoring the rate and degree of suppression of bone resorption over 1 year in patients treated with 30 mg of intravenous pamidronate for 3 consecutive days. The clinical utility of GHL was compared with that of urinary hydroxyproline/creatinine and deoxypyridinoline/creatinine and with bone isoenzyme of serum alkaline phosphatase. The results suggest that GHL is a quantitative marker of the activity of Paget's bone disease. GHL is less sensitive than hydroxyproline, deoxypyridinolone and bone alkaline phosphatase in monitoring treatment of Paget's disease. The assay of GHL is easier, faster and less costly than that of hydroxyproline or deoxypyridinoline and it can be easily standardized.
- MeSH
- alkalická fosfatasa analýza krev MeSH
- biologické markery krev MeSH
- dospělí MeSH
- fluorescenční spektrometrie MeSH
- hydroxylysin analogy a deriváty krev MeSH
- hydroxyprolin moč MeSH
- izoenzymy analýza krev MeSH
- kosti a kostní tkáň enzymologie MeSH
- kreatinin moč MeSH
- lidé středního věku MeSH
- lidé MeSH
- Pagetova kostní nemoc krev enzymologie MeSH
- resorpce kosti patofyziologie MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- vysokoúčinná kapalinová chromatografie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- klinické zkoušky MeSH
- Názvy látek
- alkalická fosfatasa MeSH
- biologické markery MeSH
- galactosylhydroxylysine MeSH Prohlížeč
- hydroxylysin MeSH
- hydroxyprolin MeSH
- izoenzymy MeSH
- kreatinin MeSH
The healing of myocardial infarction is accompanied by an increased accumulation of collagen in the heart muscle. Indexes of collagen metabolism (serum hydroxyproline, hydroxylysine and collagen-like protein concentration) were measured in 60 patients with myocardial infarction and 30 healthy blood donors. Determinations were carried out 1, 2, 3 days after admission and between the 10th-14th and 21st-25th day of the illness. It was found that hydroxyproline and hydroxylysine decreased in the first days of the disease, and subsequently increased in the course of the healing process accompanied by an increased collagen-like protein level. The changes did not depend on the total protein concentration.
- MeSH
- časové faktory MeSH
- dospělí MeSH
- hydroxylysin krev MeSH
- hydroxyprolin krev MeSH
- infarkt myokardu metabolismus MeSH
- kolagen metabolismus MeSH
- krevní proteiny MeSH
- lidé středního věku MeSH
- lidé MeSH
- proteiny * MeSH
- senioři MeSH
- transportní proteiny * MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- senioři MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- c1q-binding proteins MeSH Prohlížeč
- hydroxylysin MeSH
- hydroxyprolin MeSH
- kolagen MeSH
- krevní proteiny MeSH
- proteiny * MeSH
- transportní proteiny * MeSH
The susceptibility of Bacillus subtilis to amino acid analogues was found to be markedly influenced by the carbon source used in the test media. Thialysine inhibited the bacterium with a greater number of carbon sources than the other two analogues tested. 5-Hydroxylysine was inhibitory with glycerol, lactose, D-xylose, L-arabinose and soluble starch while ethionine showed toxicity with lactose, D-xylose and L-arabinose. None of these analogues were toxic at the levels tested when D-galactose was used as carbon source. The bacterium was not susceptible to thialysine with glycerol, to 5-hydroxylysine with L-arabinose and to ethionine with lactose.
- MeSH
- arabinosa metabolismus MeSH
- Bacillus subtilis účinky léků metabolismus MeSH
- cystein analogy a deriváty farmakologie MeSH
- ethionin farmakologie MeSH
- glukosa metabolismus MeSH
- glycerol metabolismus MeSH
- hydroxylysin farmakologie MeSH
- maltosa metabolismus MeSH
- mannitol metabolismus MeSH
- metabolismus sacharidů * MeSH
- Publikační typ
- časopisecké články MeSH
- srovnávací studie MeSH
- Názvy látek
- arabinosa MeSH
- cystein MeSH
- ethionin MeSH
- glukosa MeSH
- glycerol MeSH
- hydroxylysin MeSH
- maltosa MeSH
- mannitol MeSH
- S-2-aminoethyl cysteine MeSH Prohlížeč
- MeSH
- adhezivita trombocytů účinky léků MeSH
- biopsie MeSH
- difrakce rentgenového záření MeSH
- dospělí MeSH
- hydroxylysin analýza MeSH
- hydroxyprolin MeSH
- koagulopatie genetika MeSH
- kolagen farmakologie MeSH
- kolagenózy komplikace MeSH
- kurděje krev MeSH
- kůže anatomie a histologie patologie MeSH
- lidé MeSH
- lysin analýza MeSH
- molekulární konformace MeSH
- morčata MeSH
- prolin analýza MeSH
- trombocytopatie etiologie MeSH
- věkové faktory MeSH
- zvířata MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- morčata MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- hydroxylysin MeSH
- hydroxyprolin MeSH
- kolagen MeSH
- lysin MeSH
- prolin MeSH
EHT and CNDO/2 types of calculations permit the interpretation of the course of hydroxylation of collagenous proline and lysine. Calculations were performed for the models of proline (I), zwitterion of proline (II), proline-containing peptide (III), and lysine (IV). The theoretical results are consistent with an electrophilic mechanism.
- MeSH
- elektrochemie metody MeSH
- hydroxylace MeSH
- hydroxylysin chemie MeSH
- hydroxyprolin chemie MeSH
- kolagen chemie MeSH
- konformace proteinů MeSH
- lysin chemie MeSH
- molekulární konformace MeSH
- molekulární modely MeSH
- prolin chemie MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- hydroxylysin MeSH
- hydroxyprolin MeSH
- kolagen MeSH
- lysin MeSH
- prolin MeSH
- Klíčová slova
- AMINOACIDURIA, RENAL *, BONE DISEASES *, HYDROXYPROLINE *, LYSINE *, MUCOPOLYSACCHARIDES *, OSSIFICATION, PATHOLOGIC *, OSTEITIS DEFORMANS *, OSTEOMALACIA *, OSTEOPOROSIS *, PROLINE *,
- MeSH
- glykosaminoglykany * MeSH
- heterotopická osifikace * MeSH
- hydroxylysin * MeSH
- hydroxyprolin * MeSH
- kostní matrix * MeSH
- ledviny * MeSH
- lidé MeSH
- lysin * MeSH
- nemoci kostí * MeSH
- osteomalacie * MeSH
- osteoporóza * MeSH
- Pagetova kostní nemoc * MeSH
- prolin * MeSH
- renální aminoacidurie * MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- glykosaminoglykany * MeSH
- hydroxylysin * MeSH
- hydroxyprolin * MeSH
- lysin * MeSH
- prolin * MeSH
