JavaScript NENÍ povolen !

* Zobrazit nápovědu

MeSH: chlorované uhlovodíky-farmakologie

5 záznamů v PubMed Filtry

Článek

Dioxins and dioxin-like compounds in composts and digestates from European countries as determined by the in vitro bioassay and chemical analysis

Beníšek, Martin
Autor Beníšek, Martin Masaryk University, Faculty of Science, RECETOX, Brno, Czech Republic
Kukučka, Petr
Autor Kukučka, Petr Masaryk University, Faculty of Science, RECETOX, Brno, Czech Republic
Mariani, Giulio
Autor Mariani, Giulio European Commission, DG Joint Research Centre (JRC), Institute for Environment and Sustainability, Unit H.01-Water Resources Unit, Ispra, Italy
Suurkuusk, Gert
Autor Suurkuusk, Gert European Commission, DG Joint Research Centre (JRC), Institute for Environment and Sustainability, Unit H.01-Water Resources Unit, Ispra, Italy
Gawlik, Bernd M
Autor Gawlik, Bernd M European Commission, DG Joint Research Centre (JRC), Institute for Environment and Sustainability, Unit H.01-Water Resources Unit, Ispra, Italy
Locoro, Giovanni
Autor Locoro, Giovanni European Commission, DG Joint Research Centre (JRC), Institute for Environment and Sustainability, Unit H.01-Water Resources Unit, Ispra, Italy
Giesy, John P
Autor Giesy, John P Department of Veterinary Biomedical Sciences and Toxicology Centre, University of Saskatchewan, SK, Canada; Department of Biology & Chemistry and State Key Laboratory in Marine Pollution, City University of Hong Kong, Kowloon, Hong Kong Special Administrative Region; School of Biological Sciences, University of Hong Kong, Hong Kong Special Administrative Region; State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, People's Republic of China
Bláha, Luděk
Autor Bláha, Luděk Masaryk University, Faculty of Science, RECETOX, Brno, Czech Republic

Chemosphere. 2015 Mar ; 122 () : 168-175. [epub] 20141215

ISSN 1879-1298 | 0045-6535
Zdroj

Aerobic composting and anaerobic digestion plays an important role in reduction of organic waste by transforming the waste into humus, which is an excellent soil conditioner. However, applications of chemical-contaminated composts on soils may have unwanted consequences such as accumulation of persistent compounds and their transfer into food chains. The present study investigated burden of composts and digestates collected in 16 European countries (88 samples) by the compounds causing dioxin-like effects as determined by use of an in vitro transactivation assay to quantify total concentrations of aryl hydrocarbon receptor-(AhR) mediated potency. Measured concentrations of 2,3,7,8-Tetrachlorodibeno-p-dioxin (2,3,7,8-TCDD) equivalents (TEQbio) were compared to concentrations of polycyclic aromatic hydrocarbons (PAHs) and selected chlorinated compounds, including polychlorinated dibenzo-p-dioxins/furans (PCDD/Fs), co-planar polychlorinated biphenyls (PCBs), indicator PCB congeners and organochlorine pesticides (OCPs). Median concentrations of TEQbio (dioxin-like compounds) determined by the in vitro assay in crude extracts of various types of composts ranged from 0.05 to 1.2 with a maximum 8.22μg (TEQbio)kg(-1) dry mass. Potencies were mostly associated with less persistent compounds such as PAHs because treatment with sulfuric acid removed bioactivity from most samples. The pan-European investigation of contamination by organic contaminants showed generally good quality of the composts, the majority of which were in compliance with conservative limits applied in some countries. Results demonstrate performance and added value of rapid, inexpensive, effect-based monitoring, and points out the need to derive corresponding effect-based trigger values for the risk assessment of complex contaminated matrices such as composts.

Klíčová slova
Biodetection tools, Compost, Digestate, Dioxin, Effect-based monitoring, PAHs,
MeSH
biotest MeSH
chlorované uhlovodíky analýza farmakologie MeSH
dioxiny analýza farmakologie MeSH
hodnocení rizik MeSH
krysa rodu Rattus MeSH
látky znečišťující půdu analýza farmakologie MeSH
nádorové buněčné linie MeSH
polycyklické aromatické uhlovodíky analýza farmakologie MeSH
půda chemie MeSH
receptory aromatických uhlovodíků metabolismus MeSH
zvířata MeSH
Check Tag
krysa rodu Rattus MeSH
zvířata MeSH
Publikační typ
časopisecké články MeSH
práce podpořená grantem MeSH
Geografické názvy
Evropa MeSH
Názvy látek
chlorované uhlovodíky MeSH
dioxiny MeSH
látky znečišťující půdu MeSH
polycyklické aromatické uhlovodíky MeSH
půda MeSH
receptory aromatických uhlovodíků MeSH

Článek

Synthesis, antimycobacterial, antifungal and photosynthesis-inhibiting activity of chlorinated N-phenylpyrazine-2-carboxamides

Molecules (Basel, Switzerland). 2010 Nov 26 ; 15 (12) : 8567-81. [epub] 20101126

Molecules
ISSN 1420-3049
Zdroj

A series of sixteen pyrazinamide analogues with the -CONH- linker connecting the pyrazine and benzene rings was synthesized by the condensation of chlorides of substituted pyrazinecarboxylic acids with ring-substituted (chlorine) anilines. The prepared compounds were characterized and evaluated for their antimycobacterial and antifungal activity, and for their ability to inhibit photosynthetic electron transport (PET). 6-Chloro-N-(4-chlorophenyl)pyrazine-2-carboxamide manifested the highest activity against Mycobacterium tuberculosis strain H37Rv (65% inhibition at 6.25 μg/mL). The highest antifungal effect against Trichophyton mentagrophytes, the most susceptible fungal strain tested, was found for 6-chloro-5-tert-butyl-N-(3,4-dichlorophenyl)pyrazine-2-carboxamide (MIC=62.5 μmol/L). 6-chloro-5-tert-butyl-N-(4-chlorophenyl)pyrazine-2-carboxamide showed the highest PET inhibition in spinach chloroplasts (Spinacia oleracea L.) chloroplasts (IC50=43.0 μmol/L). For all the compounds, the relationships between the lipophilicity and the chemical structure of the studied compounds as well as their structure-activity relationships are discussed.