Current study evaluated the synergistic potential of propolis and vitamin E against sub-acute toxicity of aluminum chloride on different biochemical parameters and liver histology. Swiss albino mice (n=42) were randomly divided into seven groups. Group I received 0.2 ml of 0.9 % saline solution, Group II received Propolis (50 mg/kg b.w.), Group III received vitamin E (150 mg/kg b.w.), Group IV received AlCl(3) 50 mg/kg b.w., Group V received AlCl(3) + Propolis, Group VI received AlCl(3) + vitamin E and Group VII received AlCl(3) + propolis + vitamin E. Blood and tissue samples were collected after 7 and 21 days. The body weight of the animals significantly increased in all groups except Group IV. The concentration of serum high density lipoprotein significantly decreased in Group IV and increased in Group V, VI and VII. The level of aspartate aminotransferase, alanine transferase, alkaline phosphatase, triglycerides, total cholesterol, and low density lipoprotein significantly increased in AlCl(3) treated group and increased in Group V, VI and VII. Tissue sections were processed and stained by hematoxylin and eosin. Group II showed cellular necrosis. Group V, VI showed decreased number of vacuolization, sinusoidal spacing and macrophage cell infiltration. Group VI showed less degenerative changes in the third week. Vitamin E and propolis in combination with Al provides more protection against AlCl(3) induced toxicity.
- MeSH
- chlorid hlinitý toxicita MeSH
- játra účinky léků patologie MeSH
- lékové postižení jater patologie prevence a kontrola MeSH
- myši MeSH
- náhodné rozdělení MeSH
- propolis aplikace a dávkování izolace a purifikace MeSH
- synergismus léků MeSH
- testy subakutní toxicity metody MeSH
- vitamin E aplikace a dávkování MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- chlorid hlinitý MeSH
- propolis MeSH
- vitamin E MeSH
End-stage renal disease is a growing health problem with increasing prevalence and high health care costs. Patients suffering from end-stage renal disease exhibit higher morbidity and mortality rates compared to the general population. These patients, who are treated using hemodialysis, typically suffer from anemia, inflammation, and oxidative stress. Inadequate dialyzer membrane biocompatibility exacerbates these negative side effects. Modifications of the composition of hemodialysis membranes have improved their biocompatibility and improve the patients' quality of life. Recently, the use of dialyzer membranes coated with bioactive compounds has also been proposed to further ameliorate dialysis-associated problems. Based on a survey of the current literature, application of bioactive membranes decreases the inflammation and oxidative stress of patients treated with hemodialysis.
- Klíčová slova
- Bioactive membranes, Hemodialysis membranes, Inflammation, Kidney disease, Oxidative stress,
- MeSH
- antioxidancia aplikace a dávkování MeSH
- biokompatibilní materiály * MeSH
- celulosa MeSH
- chronické selhání ledvin terapie MeSH
- dialýza ledvin škodlivé účinky MeSH
- kvalita života MeSH
- kyselina lipoová aplikace a dávkování MeSH
- lidé MeSH
- membrány umělé * MeSH
- oxidační stres MeSH
- sekreční inhibitory proteinas MeSH
- vitamin E aplikace a dávkování MeSH
- zánět etiologie prevence a kontrola MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
- Názvy látek
- antioxidancia MeSH
- biokompatibilní materiály * MeSH
- celulosa MeSH
- kyselina lipoová MeSH
- membrány umělé * MeSH
- sekreční inhibitory proteinas MeSH
- vitamin E MeSH
OBJECTIVE: Atherosclerosis is a major contributor to cardiovascular disease, with a higher burden on men than women during the occupational age. Intake of individual dietary antioxidants is inversely associated with risk of atherosclerosis development. We aimed to understand the relationship between dietary composite antioxidant intake and the carotid intima media thickness (cIMT), which is a proxy of atherosclerosis progression. APPROACH AND RESULTS: We performed a cross-sectional analysis that included 894 members of the Kardiovize cohort, a random urban sample population. Nutrient intakes were derived by 24-h recall. We constructed a composite dietary antioxidant index (CDAI), based on zinc, selenium, vitamin A, vitamin C, vitamin E and carotenoids. We considered the CDAI as the exposure variable and primary outcomes were the following cardio-metabolic parameters: body mass index (BMI), waist-to-hip ratio (WHR), body fat mass (BFM), systolic and diastolic blood pressure, triglycerides, HDL and LDL cholesterol, and cIMT. Associations and interactions between variables were evaluated using linear regression analyses. In women, a 1 mg increase in dietary intake of zinc or vitamin E decreased the cIMT by 3.36 and 1.48 µm, respectively, after adjusting for covariates. Similarly, the cIMT decreased by 4.72 µm for each one-unit increase in CDAI (p = 0.018). Beyond CDAI, age (β = 3.61; SE=0.89; p = 0.001), systolic blood pressure (β = 1.30; SE=0.59; p = 0.029) and triglycerides (β = 22.94; SE=10.09; p = 0.024) were significant predictors of cIMT in women. By contrast, we found no association between CDAI and cIMT in men. CONCLUSIONS: CDAI negatively associates with cIMT in women. These findings indicate that combined intake of nutrients with anti-oxidant properties might prevent the initiation and progression of arterial lesions in a sex-specific manner.
- MeSH
- antioxidancia aplikace a dávkování MeSH
- ateroskleróza krev diagnóza dietoterapie patofyziologie MeSH
- dospělí MeSH
- HDL-cholesterol krev MeSH
- index tělesné hmotnosti MeSH
- intimomediální šíře tepenné stěny * MeSH
- karotenoidy aplikace a dávkování MeSH
- kyselina askorbová aplikace a dávkování MeSH
- LDL-cholesterol krev MeSH
- lidé středního věku MeSH
- lidé MeSH
- poměr pasu a boků MeSH
- potravní doplňky * MeSH
- progrese nemoci MeSH
- průřezové studie MeSH
- selen aplikace a dávkování MeSH
- sexuální faktory MeSH
- triglyceridy krev MeSH
- tuková tkáň účinky léků MeSH
- vitamin A aplikace a dávkování MeSH
- vitamin E aplikace a dávkování MeSH
- zinek aplikace a dávkování MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- antioxidancia MeSH
- HDL-cholesterol MeSH
- karotenoidy MeSH
- kyselina askorbová MeSH
- LDL-cholesterol MeSH
- selen MeSH
- triglyceridy MeSH
- vitamin A MeSH
- vitamin E MeSH
- zinek MeSH
The normotensive (Wistar) and spontaneously hypertensive (SHR) rats were examined to assess the response of the organism to selenium (Se) overdose. Moreover, the effect of zinc (Zn) and vitamin E, i.e. dietary components interacting in many biochemical processes with Se, on the Se uptake was evaluated. The control group was fed an untreated diet, and the diets of two other groups were overdosed with Se in the form of sodium selenite (9 mg/kg) and supplemented with Zn (13 mg/kg). Two experimental groups were fed a diet supplemented with Zn (13 mg/kg) and Se at an adequate level (0.009 mg/kg); a half of the animals was supplemented with vitamin E. The results showed significant differences in the Se contents between the rat strains in case of Se-overdosed groups, where in the liver and kidney tissue Se contents of SHR rats exceeded 3- and 7-fold the normotensive ones. The Se uptake was altered by the vitamin E; no effect of Zn was observed. Activities of antioxidant enzymes were determined in the animal tissues indicating different patterns according to rat strain, tissue analysed, and administered Se dose. Thus, Se overdose, for instance, via an incorrectly prepared dietary supplement, can result in serious imbalances of the biochemical status of the animals.
- Klíčová slova
- Rattus norvegicus, biochemical parameters, selenium, vitamin E, zinc,
- MeSH
- antioxidancia aplikace a dávkování terapeutické užití MeSH
- kombinovaná farmakoterapie MeSH
- krysa rodu Rattus MeSH
- potkani inbrední SHR MeSH
- potkani inbrední WKY MeSH
- potravní doplňky MeSH
- předávkování léky farmakoterapie metabolismus MeSH
- selen aplikace a dávkování toxicita MeSH
- stopové prvky aplikace a dávkování terapeutické užití toxicita MeSH
- vitamin E aplikace a dávkování terapeutické užití MeSH
- zinek aplikace a dávkování terapeutické užití MeSH
- zvířata MeSH
- Check Tag
- krysa rodu Rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- antioxidancia MeSH
- selen MeSH
- stopové prvky MeSH
- vitamin E MeSH
- zinek MeSH
Traumatic brain injury is one of the most common causes for intervention in neurosurgery. Apart from its acute consequence, it can represent a further burden on individuals as well as society by being associated with significant comorbidity-mainly early-onset dementia. Oxidative stress is one of the crucial mechanisms conferring the damage to nervous tissue, and it is believed it could be, to some extent, influenced by dietary composition, largely by antioxidants contained in the diet. Under stressful conditions, cell-derived reactive oxygen species in the brain can induce the formation of lipid peroxides and the shifting of redox homeostasis. This review discusses the potential of vitamin E as a potent antioxidant and its derived molecules, including vitamin E-based lazaroids, in traumatic brain injury, summarizing the current state of knowledge of its role in TBI-associated dementia.
- Klíčová slova
- Dementia, Lazaroids, Oxidative stress, Traumatic brain injury, Vitamin E, α-Tocopherol,
- MeSH
- antioxidancia aplikace a dávkování MeSH
- demence etiologie prevence a kontrola MeSH
- lidé MeSH
- potravní doplňky MeSH
- traumatické poranění mozku komplikace dietoterapie psychologie MeSH
- vitamin E aplikace a dávkování analogy a deriváty MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
- Názvy látek
- antioxidancia MeSH
- vitamin E MeSH
PURPOSE: The aim of the study was to assess the relationships between individual-level dietary intakes of antioxidant vitamins C, E and beta-carotene with all-cause and cause-specific mortality in three Central and Eastern European (CEE) populations. METHODS: Data from the Health, Alcohol and Psychosocial factors in Eastern Europe cohort study were used. At the baseline survey, between 2002 and 2005, 28,945 men and women aged 45-69 years were examined in Novosibirsk (Russia), Krakow (Poland) and seven Czech towns. Deaths in the cohorts were identified through mortality registers. Cox regression was used to estimate the association between vitamin consumption and all-cause, cardiovascular (CVD) disease and cancer mortality. RESULTS: In multivariable-adjusted analyses, there were no clear inverse associations between antioxidant vitamin intakes and mortality, although in some groups, several hazard ratios (HRs) were significant. For example, in men, compared with the lowest quintile of vitamin C intake, all-cause mortality in the third and fourth quintiles was lower by 28 % (HR 0.72; 95 % CI 0.61-0.85) and by 20 % (HR 0.80; 95 % CI 0.68-0.95), respectively. CVD mortality was lower by 35 % (HR 0.65; 95 % CI 0.50-0.84) and by 23 % (HR 0.77; 95 % CI 0.59-0.99) in third and fourth quintile of vitamin C intake, respectively. In women, the third and fourth quintiles of dietary intake of vitamin E were associated with reduced risk of all-cause death by 33 % (HR 0.67; 95 % CI 0.53-0.84) and by 23 % (HR 0.77; 95 % CI 0.61-0.97), respectively. Consumption of vitamin C, vitamin E and beta-carotene was not related to CVD mortality in women and to cancer mortality in either gender. CONCLUSION: This large prospective cohort study in CEE populations with low prevalence of vitamin supplementation did not find a strong, dose-response evidence for protective effects of antioxidant vitamin intake.
- Klíčová slova
- Antioxidant vitamin, Cardiovascular, Central and Eastern Europe, Mortality,
- MeSH
- antioxidancia aplikace a dávkování MeSH
- beta-karoten aplikace a dávkování MeSH
- kardiovaskulární nemoci mortalita MeSH
- kyselina askorbová aplikace a dávkování MeSH
- lidé středního věku MeSH
- lidé MeSH
- městské obyvatelstvo * MeSH
- nádory mortalita MeSH
- následné studie MeSH
- potravní doplňky MeSH
- příčina smrti MeSH
- proporcionální rizikové modely MeSH
- prospektivní studie MeSH
- průzkumy a dotazníky MeSH
- rizikové faktory MeSH
- senioři MeSH
- socioekonomické faktory MeSH
- vitamin E aplikace a dávkování MeSH
- vitaminy aplikace a dávkování MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
- Geografické názvy
- Česká republika epidemiologie MeSH
- Polsko epidemiologie MeSH
- Rusko epidemiologie MeSH
- Názvy látek
- antioxidancia MeSH
- beta-karoten MeSH
- kyselina askorbová MeSH
- vitamin E MeSH
- vitaminy MeSH
Pro-apoptotic analogues of vitamin E (VE) exert selective anti-cancer effect on various animal cancer models. Neither suitable formulation of α-tocopheryl succinate (α-TOS), representative semi-synthetic VE analogue ester, nor suitable formulations of the other VE analogues for clinical application have been reported yet. The major factor limiting the use of VE analogues is their low solubility in aqueous solvents. Due to the hydrophobic character of VE analogues, liposomes are predetermined as suitable delivery system. Liposomal formulation prevents undesirable side effects of the drug, enhances the drug biocompatibility, and improves the drug therapeutic index. Liposomal formulations of VE analogues especially of α-TOS and α-tocopheryl ether linked acetic acid (α-TEA) have been developed. The anti-cancer effect of these liposomal VE analogues has been successfully demonstrated in pre-clinical models in vivo. Present achievements in: (i) preparation of liposomal formulations of VE analogues, (ii) physico-chemical characterization of these developed systems and (iii) testing of their biological activity such as induction of apoptosis and evaluation of anti-cancer effect are discussed in this review.
- Klíčová slova
- Alpha-tocopheryl succinate, Analogues of vitamin E, Anti-cancer drugs, Apoptosis, Drug delivery systems, Drug targeting, Liposome, Nanomedicine,
- MeSH
- alfa-tokoferol aplikace a dávkování MeSH
- apoptóza účinky léků MeSH
- farmaceutická chemie MeSH
- lékové transportní systémy metody MeSH
- lidé MeSH
- lipidy chemie MeSH
- liposomy MeSH
- nádory farmakoterapie patologie MeSH
- protinádorové látky aplikace a dávkování chemie MeSH
- rozpustnost MeSH
- vitamin E aplikace a dávkování analogy a deriváty chemie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Názvy látek
- alfa-tokoferol MeSH
- lipidy MeSH
- liposomy MeSH
- protinádorové látky MeSH
- vitamin E MeSH
OBJECTIVES: Approximately 30% of the adult Czech population smokes. Previous studies of smokers have documented diet sufficient in energy, but inadequate intake of dietary fibre, vitamins A, E, calcium and proteins. DESIGN: Nutrition was assessed between the groups of the probands (over 18 years aged, 667 smokers, 1044 nonsmokers, 428 past smokers) from 1% random sample of the Czech population. All volunteers completed a one day dietary recall after instruction from a nutrition expert. The dietary recall calculated energy, proteins, fats, vitamins C and E, cholesterol, fibre, calcium and iron intake using the Nutridan programme. RESULTS: Smokers had higher consumption of animal (p=0.0034), and total fat (p=0.0315), cholesterol (p=0.005), and lower intake of vitamin E (p=0.004) than nonsmokers. No other differences were found. The differences between past smokers and other groups were insignificant. CONCLUSION: The smokers consumed more total and animal fat, cholesterol and less of vitamin E than nonsmokers.
- MeSH
- dietní proteiny aplikace a dávkování MeSH
- dietní tuky aplikace a dávkování MeSH
- dietní železo aplikace a dávkování MeSH
- dospělí MeSH
- kardiovaskulární nemoci epidemiologie MeSH
- kouření epidemiologie MeSH
- kyselina askorbová aplikace a dávkování MeSH
- lidé středního věku MeSH
- lidé MeSH
- nádory epidemiologie MeSH
- rizikové faktory MeSH
- stravovací zvyklosti * MeSH
- vápník dietní aplikace a dávkování MeSH
- vitamin E aplikace a dávkování MeSH
- výživa - přehledy statistika a číselné údaje MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Česká republika epidemiologie MeSH
- Názvy látek
- dietní proteiny MeSH
- dietní tuky MeSH
- dietní železo MeSH
- kyselina askorbová MeSH
- vápník dietní MeSH
- vitamin E MeSH
The vitamin E analogue alpha-tocopheryl succinate (alpha-TOS) is an efficient anti-cancer drug. Improved efficacy was achieved through the synthesis of alpha-tocopheryl maleamide (alpha-TAM), an esterase-resistant analogue of alpha-tocopheryl maleate. In vitro tests demonstrated significantly higher cytotoxicity of alpha-TAM towards cancer cells (MCF-7, B16F10) compared to alpha-TOS and other analogues prone to esterase-catalyzed hydrolysis. However, in vitro models demonstrated that alpha-TAM was cytotoxic to non-malignant cells (e.g. lymphocytes and bone marrow progenitors). Thus we developed lyophilized liposomal formulations of both alpha-TOS and alpha-TAM to solve the problem with cytotoxicity of free alpha-TAM (neurotoxicity and anaphylaxis), as well as the low solubility of both drugs. Remarkably, neither acute toxicity nor immunotoxicity implicated by in vitro tests was detected in vivo after application of liposomal alpha-TAM, which significantly reduced the growth of cancer cells in hollow fiber implants. Moreover, liposomal formulation of alpha-TAM and alpha-TOS each prevented the growth of tumours in transgenic FVB/N c-neu mice bearing spontaneous breast carcinomas. Liposomal formulation of alpha-TAM demonstrated anti-cancer activity at levels 10-fold lower than those of alpha-TOS. Thus, the liposomal formulation of alpha-TAM preserved its strong anti-cancer efficacy while eliminating the in vivo toxicity found of the free drug applied in DMSO. Liposome-based targeted delivery systems for analogues of vitamin E are of interest for further development of efficient and safe drug formulations for clinical trials.
- MeSH
- alfa-tokoferol aplikace a dávkování analogy a deriváty farmakologie MeSH
- farmaceutická chemie MeSH
- lidé MeSH
- liposomy MeSH
- maleimidy aplikace a dávkování farmakologie MeSH
- melanom experimentální farmakoterapie patologie MeSH
- myši inbrední BALB C MeSH
- myši inbrední C57BL MeSH
- myši transgenní MeSH
- myši MeSH
- nádorové buněčné linie MeSH
- nádory prsu farmakoterapie patologie MeSH
- polyethylenglykoly aplikace a dávkování farmakologie MeSH
- protinádorové látky aplikace a dávkování farmakologie MeSH
- vitamin E aplikace a dávkování analogy a deriváty farmakologie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- myši MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- srovnávací studie MeSH
- Názvy látek
- alfa-tokoferol MeSH
- liposomy MeSH
- maleimidy MeSH
- polyethylenglykoly MeSH
- protinádorové látky MeSH
- tocophersolan MeSH Prohlížeč
- vitamin E MeSH
BACKGROUND: A protective role of dietary vitamin E intake on disorders related to the immune system, such as allergic diseases, has been suggested. However, results from epidemiological studies are conflicting. OBJECTIVES: The aim of present study was to analyze whether dietary vitamin E intake is related to the prevalence of allergic sensitization and total serum IgE concentrations in adult subjects. METHODS: The present study population consisted of 366 adults aged 29 to 54 years participating in the German centers of the European Community Respiratory Health Survey (ECRHS) II, Erfurt and Hamburg. A validated food frequency questionnaire was used to gather information on dietary vitamin E intake. Total serum IgE concentrations and specific IgE to common allergens were analyzed by using the Pharmacia CAP System. Allergic sensitization was defined as specific serum IgE concentration > or = 0.35 kU/l. RESULTS: The risk for allergic sensitization was substantially decreased in the middle quartiles (aOR: 0.42; 95% CI: 0.22-0.81) and the highest quartile (aOR: 0.22; 95% CI: 0.08-0.60) of total dietary vitamin E intake, after adjustment for potential confounders. Total serum IgE concentration was not statistically significantly associated with dietary vitamin E intake. CONCLUSIONS: The findings of this study suggest that dietary vitamin E intake might play a protective role in the development of allergic sensitization.
- MeSH
- alergie imunologie prevence a kontrola MeSH
- dieta * MeSH
- dietní tuky MeSH
- dospělí MeSH
- energetický příjem MeSH
- imunoglobulin E krev MeSH
- lidé středního věku MeSH
- lidé MeSH
- multicentrické studie jako téma MeSH
- prevalence MeSH
- vitamin E aplikace a dávkování MeSH
- vitaminy aplikace a dávkování MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Názvy látek
- dietní tuky MeSH
- imunoglobulin E MeSH
- vitamin E MeSH
- vitaminy MeSH
