BACKGROUND: Although the scientific literature regarding sports genomics has grown during the last decade, some genes, such as peroxisome proliferator activated receptors (PPARs), have not been fully described in terms of their role in achieving extraordinary sports performance. Therefore, the purpose of this systematic review was to determine which elite sports performance constraints are positively influenced by PPARs and their coactivators. METHODS: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were used, with a combination of PPAR and sports keywords. RESULTS: In total, 27 studies that referred to PPARs in elite athletes were included, where the Ala allele in PPARG rs1801282 was associated with strength and power elite athlete status in comparison to subelite athlete status. The C allele in PPARA rs4253778 was associated with soccer, and the G allele PPARA rs4253778 was associated with endurance elite athlete status. Other elite status endurance alleles were the Gly allele in PPARGC1A rs8192678 and the C allele PPARD rs2016520. CONCLUSIONS: PPARs can be used for estimating the potential to achieve elite status in human physical performance in strength and power, team, and aerobic sports disciplines. Carrying specific PPAR alleles can provide a partial benefit to achieving elite sports status, but does not preclude achieving elite status if they are absent.

• Klíčová slova
• PPAR, adaptation, aerobic training, anaerobic training, endurance training, genetic predisposition, human performance, muscle fibers, power, strength training,
• MeSH
• alely MeSH
• frekvence genu MeSH
• fyzická vytrvalost MeSH
• genetická variace MeSH
• lidé MeSH
• PPAR alfa genetika   MeSH
• PPAR gama genetika   MeSH
• PPARGC1A genetika   MeSH
• sportovci MeSH
• sportovní výkon MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH
• Názvy látek
• PPAR alfa MeSH
• PPAR gama MeSH
• PPARGC1A MeSH

BACKGROUND: PPARα is a transcriptional factor that controls the expression of genes involved in fatty acid metabolism, including fatty acid transport, uptake by the cells, intracellular binding, and activation, as well as catabolism (particularly mitochondrial fatty acid oxidation) or storage. PPARA gene polymorphisms may be crucial for maintaining lipid homeostasis and in this way, being responsible for developing specific training-induced physiological reactions. Therefore, we have decided to check if post-training changes of body mass measurements as well as chosen biochemical parameters are modulation by the PPARA genotypes. METHODS: We have examined the genotype and alleles' frequencies (described in PPARA rs1800206 and rs4253778 polymorphic sites) in 168 female participants engaged in a 12-week training program. Body composition and biochemical parameters were measured before and after the completion of a whole training program. RESULTS: Statistical analyses revealed that PPARA intron 7 rs4253778 CC genotype modulate training response by increasing low-density lipoproteins (LDL) and glucose concentration, while PPARA Leu162Val rs1800206 CG genotype polymorphism interacts in a decrease in high-density lipoproteins (HDL) concentration. CONCLUSIONS: Carriers of PPARA intron 7 rs4253778 CC genotype and Leu162Val rs1800206 CG genotype might have potential negative training-induced cholesterol and glucose changes after aerobic exercise.

• Klíčová slova
• VO2max, aerobic training, cholesterol levels, genetic predisposition, glucose tolerance, human performance, lipid metabolism, mitochondria activity,
• Publikační typ
• časopisecké články MeSH

BACKGROUND: The peroxisome proliferator-activated receptors (PPARA, PPARG, PPARD) and their transcriptional coactivators' (PPARGC1A, PPARGC1B) gene polymorphisms have been associated with muscle morphology, oxygen uptake, power output and endurance performance. The purpose of this review is to determine whether the PPARs and/or their coactivators' polymorphisms can predict the training response to specific training stimuli. METHODS: In accordance with the Preferred Reporting Items for Systematic Reviews and Meta Analyses, a literature review has been run for a combination of PPARs and physical activity key words. RESULTS: All ten of the included studies were performed using aerobic training in general, sedentary or elderly populations from 21 to 75 years of age. The non-responders for aerobic training (VO₂peak increase, slow muscle fiber increase and low-density lipoprotein decrease) are the carriers of PPARGC1A rs8192678 Ser/Ser. The negative responders for aerobic training (decrease in VO₂peak) are carriers of the PPARD rs2267668 G allele. The negative responders for aerobic training (decreased glucose tolerance and insulin response) are subjects with the PPARG rs1801282 Pro/Pro genotype. The best responders to aerobic training are PPARGC1A rs8192678 Gly/Gly, PPARD rs1053049 TT, PPARD rs2267668 AA and PPARG rs1801282 Ala carriers. CONCLUSIONS: The human response for aerobic training is significantly influenced by PPARs' gene polymorphism and their coactivators, where aerobic training can negatively influence glucose metabolism and VO₂peak in some genetically-predisposed individuals.

• Klíčová slova
• VO2max, VO2peak, aerobic training, anaerobic threshold, cholesterol levels, genetic predisposition, glucose tolerance, human performance, insulin response, mitochondria activity, muscle fibers,
• MeSH
• dospělí MeSH
• jednonukleotidový polymorfismus * MeSH
• kondiční příprava * MeSH
• kosterní svaly metabolismus   fyziologie   MeSH
• lidé středního věku MeSH
• lidé MeSH
• PPARGC1A genetika   MeSH
• proteiny vázající RNA MeSH
• receptory aktivované proliferátory peroxizomů genetika   MeSH
• senioři MeSH
• spotřeba kyslíku MeSH
• transportní proteiny genetika   MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• Publikační typ
• časopisecké články MeSH
• systematický přehled MeSH
• Názvy látek
• PPARGC1A protein, human MeSH Prohlížeč
• PPARGC1A MeSH
• PPARGC1B protein, human MeSH Prohlížeč
• proteiny vázající RNA MeSH
• receptory aktivované proliferátory peroxizomů MeSH
• transportní proteiny MeSH

Background: Visual feedback may help elicit peak performance during different types of strength and power testing, but its effect during the anaerobic Wingate test is unexplored. Therefore, the purpose of this study was to determine the effect of visual feedback on power output during a hockey-specific intermittent Wingate test (AnWT6x6) consisting of 6 stages of 6 s intervals with a 1:1 work-to-rest ratio. Methods: Thirty elite college-aged hockey players performed the AnWT6x6 with either constant (n = 15) visual feedback during all 6 stages (CVF) or restricted (n = 15) visual feedback (RVF) where feedback was shown only during the 2nd through 5th stages. Results: In the first stage, there were moderate-to-large effect sizes for absolute peak power (PP) output and PP relative to body mass and PP relative to fat-free mass. However, the remaining stages (2⁻6) displayed small or negligible effects. Conclusions: These data indicate that visual feedback may play a role in optimizing power output in a non-fatigued state (1st stage), but likely does not play a role in the presence of extreme neuromuscular fatigue (6th stage) during Wingate testing. To achieve the highest peak power, coaches and researchers could provide visual feedback during Wingate testing, as it may positively influence performance in the early stages of testing, but does not result in residual fatigue or negatively affect performance during subsequent stages.

• Klíčová slova
• anaerobic performance, elite sport, intermittent load, peak power,
• Publikační typ
• časopisecké články MeSH

The strength ratio between hamstrings and quadriceps (H/Q) is associated with knee injuries as well as hip abductor muscle (HAB) weakness. Sixteen resistance trained men (age, 32.5 ± 4.2 years) performed 5 s maximal isometric contractions at 75° of knee flexion/extension and 15° of hip abduction on a dynamometer. After this isometric test they performed a Farmer's walk exercise to find out if the muscle strength ratio predicted the electromyography amplitude expressed as a percentage of maximum voluntary isometric contraction (%MVIC). The carried load represented a moderate intensity of 75% of the exercise six repetitions maximum (6RM). Electromyography data from the vastus medialis (VM), vastus lateralis (VL), biceps femoris (BF) and gluteus medius (Gmed) on each leg were collected during the procedure. The groups selected were participants with H/Q ≥ 0.5, HQ < 0.5, HAB/H ≥ 1, HAB/H < 1, HAB/Q ≥ 0.5 and HAB/Q < 0.5. One way ANOVA showed that Gmed activity was significantly greater in the group with HAB/H < 1 (42 ± 14 %MVIC) as compared to HAB/H ≥ 1 (26 ± 10 %MVIC) and HAB/Q < 0.5 (47 ± 19 %MVIC) compared to HAB/Q ≥ 0.5 (26 ± 12 %MVIC). The individuals with HAB/H < 1 were found to have greater activation of their Gmed during the Farmer's walk exercise. Individuals with HAB/Q < 0.5 had greater activation of the Gmed. Gmed strength ratios predict the muscle involvement when a moderate amount of the external load is used. The Farmer's walk is recommended as an exercise which can strengthen the gluteus medius, especially for individuals with a HAB/H ratio < 1 and HAB/Q < 0.5.

• Klíčová slova
• MVIC, electromyography, hip abduction, isometric strength, loaded walking,
• Publikační typ
• časopisecké články MeSH