Antibiotic resistance in staphylococcal strains and its impact on public health and agriculture are global problems. The development of new anti-staphylococcal agents is an effective strategy for addressing the increasing incidence of bacterial resistance. In this study, ethanolic extracts of Cannabis sativa L. made from plant parts harvested during the whole vegetation cycle under various nutritional treatments were assessed for in vitro anti-staphylococcal effects. The results showed that all the cannabis extracts tested exhibited a certain degree of growth inhibition against bacterial strains of Staphylococcus aureus, including antibiotic-resistant and antibiotic-sensitive forms. The highest antibacterial activity of the extracts was observed from the 5th to the 13th week of plant growth across all the nutritional treatments tested, with minimum inhibitory concentrations ranging from 32 to 64 µg/mL. Using HPLC, Δ9-tetrahydrocannabinolic acid (THCA) was identified as the most abundant cannabinoid in the ethanolic extracts. A homolog of THCA, tetrahydrocannabivarinic acid (THCVA), reduced bacterial growth by 74%. These findings suggest that the cannabis extracts tested in this study can be used for the development of new anti-staphylococcal compounds with improved efficacy.

• MeSH
• agonisté kanabinoidních receptorů farmakologie   MeSH
• antibakteriální látky farmakologie   MeSH
• Cannabis * MeSH
• ethanol farmakologie   MeSH
• halucinogeny * farmakologie   MeSH
• kanabinoidy * farmakologie   MeSH
• rostlinné extrakty farmakologie   MeSH
• Staphylococcus MeSH
• tetrahydrokanabinol farmakologie   MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• agonisté kanabinoidních receptorů MeSH
• antibakteriální látky MeSH
• ethanol MeSH
• halucinogeny * MeSH
• kanabinoidy * MeSH
• rostlinné extrakty MeSH
• tetrahydrokanabinol MeSH

Cannabis sativa L., a plant historically utilized for textile fibers, oil, and animal feed, is progressively being recognized as a potential food source. This review elucidates the nutritional and functional attributes of hemp and cannabidiol (CBD) within the context of food science. Hemp is characterized by the presence of approximately 545 secondary metabolites, among which around 144 are bioactive cannabinoids of primary importance. The study looks in detail at the nutritional components of cannabis and the potential health benefits of CBD, encompassing anti-inflammatory, anxiolytic, and antipsychotic effects. The review deals with the legislation and potential applications of hemp in the food industry and with the future directions of cannabis applications as well. The paper emphasizes the need for more scientific investigation to validate the safety and efficacy of hemp components in food products, as current research suggests that CBD may have great benefits for a wide range of consumers.

• Klíčová slova
• CBD, cannabinoids, food products, functional properties, health benefits, hemp, nutrition,
• MeSH
• Cannabis * MeSH
• halucinogeny * MeSH
• kanabidiol * farmakologie   MeSH
• kanabinoidy * farmakologie   MeSH
• potravní doplňky MeSH
• zvířata MeSH
• Check Tag
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH
• Názvy látek
• halucinogeny * MeSH
• kanabidiol * MeSH
• kanabinoidy * MeSH

Cannabidiol (CBD), a non-psychotropic cannabinoid produced by the genus Cannabis, is a phytoceutical that activates the endocannabinoid system (ECS) through binding to CB1 and CB2 receptors. The ECS is involved in cellular homeostasis and regulates metabolic processes in virtually all mammalian tissues. Published studies on CBD focus, inter alia, on its use in prophylaxis and as an anti-inflammatory agent. Here the authors present a critical assessment of the effects of CBD on inflammatory periodontal diseases caused by bacterial virulence factors, and evaluate critically the possible benefits and drawbacks of CBD use in dentistry. Particular attention is paid to the interaction of CBD with microbially colonized oral tissues, the inflammatory response in relation to the immune response, and the destruction/regeneration of hard and soft tissues of the periodontium.

• Klíčová slova
• CB1/2 receptors, bacterial virulence, cannabidiol, endocannabinoid system, gingivitis, immune system, microbial colonisation, periodontitis,
• MeSH
• analgetika MeSH
• kanabidiol * metabolismus   farmakologie   terapeutické užití   MeSH
• kanabinoidy * MeSH
• lidé MeSH
• nemoci parodontu * farmakoterapie   MeSH
• receptor kanabinoidní CB1 MeSH
• savci metabolismus   MeSH
• zvířata MeSH
• Check Tag
• lidé MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH
• Názvy látek
• analgetika MeSH
• kanabidiol * MeSH
• kanabinoidy * MeSH
• receptor kanabinoidní CB1 MeSH