Several dicarbonyl and tricarbonyl sugars were prepared by the use of fungal enzymes and the antimicrobial effects of their N,N-diphenylhydrazine derivatives were tested. G+ bacteria were more sensitive than G- bacteria especially in the group of disubstituted compounds. Peracetyled derivatives were not active. No inhibition of yeast growth was found.

• MeSH
• Anti-Bacterial Agents pharmacology   MeSH
• Bacillus subtilis drug effects   MeSH
• Escherichia coli drug effects   MeSH
• Phenylhydrazines metabolism   pharmacology   MeSH
• Ketoses metabolism   pharmacology   MeSH
• Microbial Sensitivity Tests MeSH
• Publication type
• Journal Article MeSH
• Comparative Study MeSH
• Names of Substances
• Anti-Bacterial Agents MeSH
• Phenylhydrazines MeSH
• Ketoses MeSH

Antibacterial, antifungal and antiprotozoal effects of nine mono- and bishydrazones of glycolaldehyde, glyoxal, methoxyacetaldehyde and glutaraldehyde were studied using eight model organisms. It was found that bishydrazones are much more efficient antimicrobial agents than monohydrazones in the case of all model microorganisms.

• MeSH
• Anti-Bacterial Agents MeSH
• Anti-Infective Agents pharmacology   MeSH
• Bacillus drug effects   MeSH
• Biotransformation MeSH
• Candida albicans drug effects   MeSH
• Escherichia coli drug effects   MeSH
• Phenylhydrazines biosynthesis   metabolism   MeSH
• Hydrazones metabolism   pharmacology   MeSH
• Micrococcus drug effects   MeSH
• Pseudomonas aeruginosa drug effects   MeSH
• Saccharomyces cerevisiae drug effects   MeSH
• Staphylococcus aureus drug effects   MeSH
• Trichomonas vaginalis drug effects   MeSH
• Animals MeSH
• Check Tag
• Animals MeSH
• Publication type
• Journal Article MeSH
• Names of Substances
• Anti-Bacterial Agents MeSH
• Anti-Infective Agents MeSH
• Phenylhydrazines MeSH
• Hydrazones MeSH

Antiprotozoal effects of hydrazones derived from compounds with 1 to 4 carbon atoms were studied on the model organism Trichomonas vaginalis isolated from a female patient with acute urogenital trichomoniasis.

• MeSH
• Antiprotozoal Agents pharmacology   MeSH
• Hydrazones pharmacology   MeSH
• Metronidazole pharmacology   MeSH
• Trichomonas vaginalis drug effects   MeSH
• Animals MeSH
• Check Tag
• Animals MeSH
• Publication type
• Journal Article MeSH
• Comparative Study MeSH
• Names of Substances
• Antiprotozoal Agents MeSH
• Hydrazones MeSH
• Metronidazole MeSH

The antimicrobial effect of 14 sugar osazones and anhydro sugars was studied with model strains of Micrococcus luteus, Bacillus licheniformis, Escherichia coli and strains Staphylococcus aureus and Pseudomonas aeruginosa isolated from clinical material. The relationship between the structure of these compounds, their solubility in water and 1-octanol and antimicrobial effect was investigated.

• MeSH
• Bacillus drug effects   MeSH
• Bacteria drug effects   MeSH
• Escherichia coli drug effects   MeSH
• Hexoses pharmacology   MeSH
• Hydrazones pharmacology   MeSH
• Micrococcus drug effects   MeSH
• Pseudomonas aeruginosa drug effects   MeSH
• Solubility MeSH
• Staphylococcus aureus drug effects   MeSH
• Structure-Activity Relationship MeSH
• Publication type
• Journal Article MeSH
• Names of Substances
• Hexoses MeSH
• Hydrazones MeSH

When investigating the possible antitrichomodal effect of 41 phenylsazones, nitro- and dinitro-phenylhydrazones a significant inhibitory effect on multiplication of Trichomonas foetus could be detected in 14 derivatives; eight derivatives were ineffective, other derivatives exhibited only a slight effect. The inhibitory effect of most compounds increased after acetylation. Toxicity of seven effective compounds was determined in vivo. Mutagenicity of these compounds was followed with microorganisms and their cytotoxicity with tumor EAC cells. Two of the effective compounds exhibited also a significant mutagenic effect, three of eight compounds had a pronounced cytotoxic effect, three of eight compounds had a pronounced cytotoxic effect in vitro on the EAC cells, in which they inhibited mainly the incorporation of adenine.

• MeSH
• Antitrichomonal Agents pharmacology   toxicity   MeSH
• Carcinoma, Ehrlich Tumor drug therapy   metabolism   MeSH
• Hydrazones pharmacology   MeSH
• Mice MeSH
• Antineoplastic Agents pharmacology   MeSH
• Carbohydrates pharmacology   MeSH
• Cattle MeSH
• In Vitro Techniques MeSH
• Mutagenicity Tests MeSH
• Trichomonas drug effects   growth & development   MeSH
• Animals MeSH
• Check Tag
• Male MeSH
• Mice MeSH
• Cattle MeSH
• Animals MeSH
• Publication type
• Journal Article MeSH
• Names of Substances
• Antitrichomonal Agents MeSH
• Hydrazones MeSH
• Antineoplastic Agents MeSH
• Carbohydrates MeSH

• MeSH
• Anti-Bacterial Agents pharmacology   MeSH
• Bacillus drug effects   MeSH
• Chemical Phenomena MeSH
• Chemistry MeSH
• Escherichia coli drug effects   MeSH
• Hydrazones pharmacology   MeSH
• Micrococcus drug effects   MeSH
• Monosaccharides pharmacology   MeSH
• Publication type
• Journal Article MeSH
• Comparative Study MeSH
• Names of Substances
• Anti-Bacterial Agents MeSH
• Hydrazones MeSH
• Monosaccharides MeSH

Inhibitory effects of compounds with guaiacyl and syringyl structure, representing the structure of native lignin, were studied on model cultures of bacteria, yeasts, yeast-like microorganisms and moulds. Isoeugenol exhibited the most pronounced inhibitory effect on growth of the studied microorganisms.

• MeSH
• Anti-Bacterial Agents pharmacology   MeSH
• Antifungal Agents pharmacology   MeSH
• Aspergillus niger drug effects   MeSH
• Bacillus drug effects   MeSH
• Candida albicans drug effects   MeSH
• Chemical Phenomena MeSH
• Chemistry MeSH
• Escherichia coli drug effects   MeSH
• Eugenol pharmacology   MeSH
• Guaiacol analogs & derivatives   pharmacology   MeSH
• Isomerism MeSH
• Gallic Acid analogs & derivatives   pharmacology   MeSH
• Lignin analogs & derivatives   analysis   pharmacology   MeSH
• Micrococcus drug effects   MeSH
• Microbial Sensitivity Tests MeSH
• Saccharomyces cerevisiae drug effects   MeSH
• Terpenes pharmacology   MeSH
• Publication type
• Journal Article MeSH
• Names of Substances
• Anti-Bacterial Agents MeSH
• Antifungal Agents MeSH
• Eugenol MeSH
• Guaiacol MeSH
• Gallic Acid MeSH
• Lignin MeSH
• Terpenes MeSH

The antibacterial effect of 19 4-nitrophenylhydrazones, isonicotinoylhydrazones, and N-4-nitrophenylhydrazones, of 9 mono- and 2 disaccharides was tested with Micrococcus luteus, Bacillus licheniformis and Escherichia coli.

• MeSH
• Amino Sugars pharmacology   MeSH
• Anti-Bacterial Agents pharmacology   MeSH
• Bacillus drug effects   MeSH
• Bacteria drug effects   MeSH
• Escherichia coli drug effects   MeSH
• Phenylhydrazines pharmacology   MeSH
• Hydrazones pharmacology   MeSH
• Isoniazid analogs & derivatives   pharmacology   MeSH
• Micrococcus drug effects   MeSH
• Publication type
• Journal Article MeSH
• Names of Substances
• Amino Sugars MeSH
• Anti-Bacterial Agents MeSH
• Phenylhydrazines MeSH
• Hydrazones MeSH
• Isoniazid MeSH

• MeSH
• Bacillus drug effects   MeSH
• Escherichia coli drug effects   MeSH
• Phenylhydrazines pharmacology   MeSH
• Hydrazones pharmacology   MeSH
• Micrococcus drug effects   MeSH
• Structure-Activity Relationship MeSH
• Publication type
• Journal Article MeSH
• Names of Substances
• Phenylhydrazines MeSH
• Hydrazones MeSH