COVID-19 pandemic has massive impact on the whole world, lead to the death of milions of people and required excessive restrictions with large economical, psychological and other impacts. Post-COVID syndrome is defined according to the Czech pneumological and phtizeological society as a complex of symptoms persisting for more than 12 weeks from the acute stage of COVID-19 and which is not possible to explain by other causes. Exact pathopysiological mechanisms and its frequency are still not known, and the data from the literature are not consisent. We present case reports of 2 patients with very different disease and convalescence course. COVID-19 and post-COVID syndrome represent large space for the further research. The prediction of the persisting limitations and other consequencies of the diseases is still not possible. Even though there is usualy higher incidence of post-COVID symptoms in patients surviving severe COVID-19 course, the presented case reports show paradoxically exactly the oposite situation.

• Klíčová slova
• COVID-19, case reports, post‑COVID,
• MeSH
• COVID-19 * MeSH
• lidé MeSH
• pandemie MeSH
• SARS-CoV-2 MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH

Kidney transplant recipients are a very vulnerable population at risk of severe course and death from Covid-19. Several antiviral drugs are now available for the treatment of nonhospitalized individuals with mild to moderate Covid-19 and hospitalized patients with severe disease. The combination of monoclonal antibodies is also available to be used as pre-exposure prophylaxis in elderly patients. Previously used monoclonal antibodies for post-exposure prophylaxis are no longer effective because of the new mutations and are no longer recommended. Although the immune response to Covid-19 vaccines is impaired in kidney transplant recipients, the effectiveness of the Covid-19 vaccines was described even in this immunocompromised group. Therefore vaccination, together with anti-epidemic measures, remains the most important tool to prevent Covid-19.

• Klíčová slova
• COVID-19, Monoclonal antibodies, SARS‑CoV- 2, antiviral drugs, kidney transplantation, mRNA vaccine, monoclonal antibodies, pre-exposure prophylaxis, pre‑exposure prophylaxis, vaccination, vaccine effectiveness, vector vaccine,
• MeSH
• COVID-19 * prevence a kontrola   MeSH
• lidé MeSH
• monoklonální protilátky MeSH
• senioři MeSH
• transplantace ledvin * škodlivé účinky   MeSH
• vakcinace MeSH
• vakcíny proti COVID-19 * aplikace a dávkování   MeSH
• Check Tag
• lidé MeSH
• senioři MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• monoklonální protilátky MeSH
• vakcíny proti COVID-19 * MeSH

Infection with a new type of coronavirus surprised with the diversity of its clinical symptoms. The disease may be asymptomatic, with only mild symptoms in the form of olfactory loss, general weakness or flu-like symptoms. However, in some patients, COVID-19 infection can be severe, with hypercoagulation being a common finding, with vascular endothelial damage and the consequent risk of venous and arterial thrombotic complications. Coa-gulopathy subsequently significantly worsens the prognosis of patients and increases overall mortality. Recently, a new term has been introduced to indicate the presence of activated hemostasis in SARS-CoV-2 infection - coagulopathy associated with COVID-19 (CAC). The current global pandemic of COVID-19 has triggered intensive research on the disease, which has clarified a number of findings about the infection, but we still have many unanswered questions, especially regarding possible treatment.

• Klíčová slova
• COVID-19, Coagulopathy, D-dimers, Heparin, heparine, immuno-trombosis, liver cirrhosis,
• MeSH
• COVID-19 * MeSH
• koagulopatie * etiologie   MeSH
• koronavirové infekce * epidemiologie   MeSH
• lidé MeSH
• pandemie MeSH
• SARS-CoV-2 MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH

The current situation of the COVID-19 pandemic has brought entirely new challenges to the health care professionals as well as to the general public, and together with them a number of new problems that the society needs to deal with. One of the groups of new challenges are undoubtedly ethical issues. For physicians in their daily practice, it is important to realize the significant role of ethical aspects during an epidemic or pandemic. The article aims to acquaint health care professionals with ethical principles in general, with their distinctiveness and application in the course of infectious diseases, and with the main ethical aspects of the COVID-19 treatment during the pandemic. One of the most important topics of the subject-matter experts discussions, which took place in connection with preparation of recommendations for the allocation criteria of scarce resources in the provision of health care services in the context of the COVID-19 pandemic, is particularly the allocation of scarce resources based on age and discrimination. The intention of the article is to support healthcare professionals to fulfil their responsibilities in providing health care services in a professional and equitable way that does not conflict with any legal obligations.

• Klíčová slova
• COVID-19, age discrimination, allocation of scarce resources, ethical aspects, ethical dilemmas, ethical principles, medical ethics,
• MeSH
• farmakoterapie COVID-19 * MeSH
• koronavirové infekce * epidemiologie   MeSH
• lidé MeSH
• pandemie MeSH
• SARS-CoV-2 MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH

This scoping review summarizes evidence regarding the impact of civic and community engagement of young people during the COVID-19 pandemic. Recognizing that the global pandemic not only brought challenges but also new opportunities to take a stance and to actively engage in communities and society, this review assesses the impact of the COVID-19 pandemic on young people's civic engagement across different cultural contexts and identifies key factors and processes that enable young people to engage with their community or society at large. We summarize evidence from 27 original research papers, one thought piece, and four reports conducted by global organizations such as the United Nations and OECD. Relevant research was conducted in the United States, Europe, China, Southeast Asia, South Africa, and New Zealand, addressing the development of leadership skills, civic responsibility, critical consciousness, civic and community engagement, as well as social integration. Key factors that facilitated civic engagement include national investments in online learning facilities, support for basic needs (such as education, health, and employment), and promotion and encouragement of local initiatives. The studies differed in their focus depending on the socio-cultural context encountered and future research needs to consider cultural variations and different demands on young people to inform effective practices for supporting young people's active engagement in society.

• Klíčová slova
• COVID‐19, civic engagement, positive youth development, scoping review,
• MeSH
• COVID-19 * epidemiologie   psychologie   MeSH
• lidé MeSH
• mladiství MeSH
• mladý dospělý MeSH
• pandemie MeSH
• SARS-CoV-2 * MeSH
• sociální odpovědnost MeSH
• účast komunity MeSH
• vůdcovství MeSH
• Check Tag
• lidé MeSH
• mladiství MeSH
• mladý dospělý MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH

OBJECTIVE: The COVID-19 pandemic had a major impact on medical care. This study evaluated the influence of the pandemic on blood pressure (BP) control and hypertension phenotypes as assessed by office and 24-hour ambulatory BP monitoring (ABPM). DESIGN AND METHODS: Data were collected from 33 centers including Excellence Centers of the European Society of Hypertension. Two groups of patients with treated hypertension were compared. Pandemic group: including participants who had ABPM twice - at visit 2 during the COVID-19 pandemic and visit 1 performed 9-15 months prior to visit 2. Pre-pandemic group: had ABPM at two visits, performed before the pandemic within 9-15 months interval. We determined the following hypertension phenotypes: masked hypertension, white coat hypertension, sustained controlled hypertension (SCH) and sustained uncontrolled hypertension (SUCH). We analyzed the prevalence of phenotypes and their changes between visits. RESULTS: Data of 1419 patients, 616 (43 %) in the pandemic group and 803 (57 %) in the pre-pandemic group, were analyzed. At baseline (visit 1), the prevalence of hypertension phenotypes did not differ between groups. In the pandemic group, the change in hypertension phenotypes between two visits was not significant (p = 0.08). In contrast, in the pre-pandemic group, the prevalence of SCH increased during follow-up (28.8 % vs 38.4 %, p < 0.01) while the prevalence of SUCH decreased (34.2 % vs 27.8 %, p < 0.01). In multivariable adjusted analysis, the only factor influencing negative changes of hypertension phenotypes was the COVID-19 pandemic period. CONCLUSION: These results indicate a negative impact of the COVID-19 pandemic on BP control assessed by hypertension phenotypes.

• Klíčová slova
• Ambulatory blood pressure monitoring, Antihypertensive treatment, Covid-19 pandemic, Hypertension, Hypertension phenotypes,
• MeSH
• ambulantní monitorování krevního tlaku * MeSH
• antihypertenziva terapeutické užití   MeSH
• COVID-19 * epidemiologie   MeSH
• fenotyp * MeSH
• hypertenze * epidemiologie   MeSH
• krevní tlak MeSH
• lidé středního věku MeSH
• lidé MeSH
• maskovaná hypertenze epidemiologie   diagnóza   MeSH
• prevalence MeSH
• SARS-CoV-2 MeSH
• senioři MeSH
• syndrom bílého pláště epidemiologie   diagnóza   MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• multicentrická studie MeSH
• Geografické názvy
• Evropa epidemiologie   MeSH
• Názvy látek
• antihypertenziva MeSH

Pneumatocele is a cavity, which may develop rarely as a complication of pneumonia. It is more common in patients requiring ventilation support. After COVID-19 pneumonia, there are only several case reports described. Our case report is about a male patient without any serious commorbities. The patient had bilateral multiple pneumatocele which have formed in postacute phase of moderate course of COVID-19. Other possible causes have been exluded by a complex examination. During the follow-up there was a clear gradual spontaneous resorption of the finding. The patient is still in very good clinical condition.

• Klíčová slova
• COVID-19, complication, complications, pneumatocele, pneumonia,
• MeSH
• COVID-19 * komplikace   MeSH
• lidé MeSH
• pneumonie * MeSH
• Check Tag
• lidé MeSH
• mužské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH

• MeSH
• COVID-19 terapie   MeSH
• lidé MeSH
• mimotělní membránová oxygenace * MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• dopisy MeSH
• Geografické názvy
• Evropa MeSH
• Izrael MeSH

The issue of hypertension/antihypertensive treatment in patients with COVID-19 infection is discussed in the commentary.

• Klíčová slova
• COVID-19, antihypertensive drugs, hypertension,
• MeSH
• antihypertenziva terapeutické užití   MeSH
• Betacoronavirus MeSH
• COVID-19 MeSH
• hypertenze komplikace   farmakoterapie   MeSH
• koronavirové infekce komplikace   MeSH
• lidé MeSH
• pandemie MeSH
• SARS-CoV-2 MeSH
• virová pneumonie komplikace   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• Názvy látek
• antihypertenziva MeSH

The pandemic of the disease COVID-19 (COronaVIrus Disease 2019) caused by the SARS-CoV-2 coronavirus (severe acute respiratory syndrome coronavirus 2) resulted in millions of deaths and many patients have chronic consequences after overcoming the acute condition. Several vaccines have been developed in an effort to stop the spread of the virus, but they have potentially serious adverse effects. We present a case report of a patient with acute (myocarditis, exacerbation of bronchial asthma) and long-term (postural orthostatic tachycardia syndrome - POTS) complications after vaccination with the second dose of mRNA vaccine BNT162b2 (Comirnaty®). Treatment consists of regimen measures, numerous pharmacotherapy (metoprolol, ivabradine, corticosteroids, antihistamines, antiphlogistics, bronchodilators) and several nutraceuticals (maritime pine bark extract, quercetin, vitamins, magnesium, phosphatidylcholine). In the discussion, we analyze post-vaccination injury and present a short review of the current literature.

• Klíčová slova
• Asthma, COVID-19, POTS, myocarditis, nutraceuticals, vaccination,
• MeSH
• COVID-19 * prevence a kontrola   MeSH
• lidé MeSH
• SARS-CoV-2 MeSH
• vakcína BNT162 MeSH
• vakcinace MeSH
• vakcíny proti COVID-19 * škodlivé účinky   MeSH
• vitaminy MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH
• Názvy látek
• vakcína BNT162 MeSH
• vakcíny proti COVID-19 * MeSH
• vitaminy MeSH