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- Klíčová slova
- AFIBRINOGENEMIA *, LABOR *, PREGNANCY COMPLICATIONS *,
- MeSH
- afibrinogenemie * MeSH
- komplikace těhotenství * MeSH
- lidé MeSH
- porodní děj * MeSH
- těhotenství MeSH
- Check Tag
- lidé MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Klíčová slova
- LABOR *, UTERINE HEMORRHAGE *,
- MeSH
- děložní krvácení * MeSH
- lidé MeSH
- porodní děj * MeSH
- šok * MeSH
- těhotenství MeSH
- Check Tag
- lidé MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
The initiation of human parturition is not fully understood to date. The data from animal experiments demonstrate that the primary impulse for the initiation of physiological labor arises from the fetal hypothalamo-pituitary-adrenal axis (HPA). HPA is responsible for the stimulation of steroid synthesis and prostaglandin production and, in turn, the cervical dilation and the beginning of myometrial contractions. Animal experiments, however, are only partly suitable for understanding the mechanism of human labor due to substantial species-specificity. In human, the changing levels of placental CRH control the production of fetal and placental steroids. The fundamental pathogenic manifestation of spontaneous preterm labor is inflammation and similar processes also underlie the full term one. While in full term labor it is not yet precisely known what starts this process, in the preterm one, several factors have been discussed like infection, uteroplacental ischemia, and hormonal abnormalities (progesterone- or CRH-related). Inflammatory processes affect both the mother and the fetus. Fetal inflammatory response (FIRS), which can be expected for children born preterm, is frequently associated with long-term complications, in particular neurological and pulmonary. Research in this field is therefore aimed at predicting preterm labor, and on predicting the fetal inflammatory response. The role of progesterone and its receptors in the pathophysiology of preterm labor are likewise intensively studied. Clinical results on the use of additive doses of progesterone in secondary prevention of preterm labor and current experimental studies point to progesterone and its receptors playing a key role in the pathophysiology of preterm labor. This article is part of a Special Issue entitled 'Pregnancy and Steroids'.
- Klíčová slova
- CRH, Human, Inflammation, Preterm birth, Progesterone,
- MeSH
- lidé MeSH
- mediátory zánětu fyziologie MeSH
- předčasná porodní činnost imunologie metabolismus MeSH
- progesteron fyziologie MeSH
- těhotenství MeSH
- zánět metabolismus MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- Názvy látek
- mediátory zánětu MeSH
- progesteron MeSH
- Klíčová slova
- LABOR *,
- MeSH
- lidé MeSH
- porodní děj * MeSH
- těhotenství MeSH
- Check Tag
- lidé MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Klíčová slova
- CESAREAN SECTION *, LABOR/complications *,
- MeSH
- císařský řez * MeSH
- komplikace porodu * MeSH
- lidé MeSH
- porodní děj * MeSH
- těhotenství MeSH
- Check Tag
- lidé MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Klíčová slova
- LABOR, INDUCED *,
- MeSH
- indukovaný porod * MeSH
- lidé MeSH
- porodní děj * MeSH
- těhotenství MeSH
- Check Tag
- lidé MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Klíčová slova
- LABOR *,
- MeSH
- lidé MeSH
- porodní děj * MeSH
- práce * MeSH
- psychosomatické lékařství * MeSH
- těhotenství MeSH
- terapie cvičením * MeSH
- Check Tag
- lidé MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
OBJECTIVE: Comparison of dinoprostone, misoprostol and amniotomy in labor induction. METHODS: The study group included a total of 437 women who underwent consecutive induction of labor after evaluation of the indication and Bishops score. The most common indications were: postmaturity, hypertensive disease, diabetes mellitus and fetal growth restriction. In 327 cases we chose to induce labor using vaginal tablets of dinoprostone at a dose of 0.75mg, in 36 cases dinoprostone at a dose of 3mg, in 16 cases we used a vaginal insert of misoprostol (200 µg), and in 58 cases amniotomy was performed. RESULTS: In the subgroup of dinoprostone (0.75mg) the rate of vaginal delivery (including extraction delivery) was 90.2%, in the subgroup of dinoprostone (3mg) it was 91.6%, in the subgroup of misoprostol it was 100% and in the subgroup of amniotomy it was 93.1%. The time period between onset of labor induction and delivery was an average of 15.75 hours in the dinoprostone (0.75mg) subgroup, 21.41 hours in the dinoprostone (3mg) subgroup, 17.41 hours in the misoprostol subgroup and 7.49 hours in the amniotomy subgroup. CONCLUSION: Subgroup of patients with misoprostol showed the highest rate of vaginal delivery after labor induction. In the subgroup with amniotomy, the shortest time period between onset of induction and delivery was reached.
- Klíčová slova
- Bishop score, induction of labor, nulliparity, predictive factors,
- MeSH
- amniotomie MeSH
- aplikace intravaginální MeSH
- dinoproston MeSH
- indukovaný porod MeSH
- lidé MeSH
- misoprostol * MeSH
- těhotenství MeSH
- uterotonika * MeSH
- Check Tag
- lidé MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Názvy látek
- dinoproston MeSH
- misoprostol * MeSH
- uterotonika * MeSH
- Klíčová slova
- LABOR *,
- MeSH
- lidé MeSH
- porodní děj * MeSH
- práce * MeSH
- těhotenství MeSH
- Check Tag
- lidé MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
OBJECTIVE: To determine the incidence and range of anal dilation during the final phase of the second stage of labor and shortly after delivery; determine whether parity affects anal dilation; and obtain anthropometric data for future projects. METHODS: The anal diameter was measured on admission, when the fetal head crowned, and after suturing perineal injury in 142 women delivered between August 2008 and May 2009 at University Hospital Pilsen and District Hospital Klatovy, in the Czech Republic. RESULTS: The anus was dilated during the second stage of labor in all women, and differences between primiparas and multiparas were not significant. The medians for both the anteroposterior and transverse diameters were 25 mm. No measured variable was statistically associated with anal sphincter dilation. CONCLUSION: Anal dilation during the second stage of labor causes anthropometric changes to the perineum. This ought to be considered when designing anthropometric studies and in studies aiming at minimizing anal sphincter trauma during delivery.
- MeSH
- anální kanál zranění patologie MeSH
- dilatace patologická patologie MeSH
- dospělí MeSH
- druhá doba porodní * MeSH
- incidence MeSH
- kohortové studie MeSH
- komplikace porodu epidemiologie patologie MeSH
- lidé MeSH
- mladý dospělý MeSH
- perineum zranění MeSH
- porodnické kleště škodlivé účinky MeSH
- těhotenství MeSH
- vedení porodu škodlivé účinky MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mladý dospělý MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH