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Diabetic patients with acute coronary syndromes in contemporary European registries: characteristics and outcomes
M. Lettino, P. Andell, U. Zeymer, P. Widimsky, N. Danchin, A. Bardaji, JA. Barrabes, A. Cequier, MJ. Claeys, L. De Luca, J. Dörler, D. Erlinge, P. Erne, P. Goldstein, SM. Koul, G. Lemesle, TF. Lüscher, CM. Matter, G. Montalescot, D. Radovanovic,...
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, multicentrická studie, pozorovací studie, práce podpořená grantem
NLK
ProQuest Central
od 2016-10-01 do Před 1 rokem
Health & Medicine (ProQuest)
od 2016-10-01 do Před 1 rokem
PubMed
28329196
DOI
10.1093/ehjcvp/pvw049
Knihovny.cz E-zdroje
- MeSH
- akutní koronární syndrom diagnóza mortalita terapie MeSH
- časové faktory MeSH
- diabetes mellitus 1. typu diagnóza epidemiologie mortalita terapie MeSH
- diabetes mellitus 2. typu diagnóza epidemiologie mortalita terapie MeSH
- hodnocení rizik MeSH
- infarkt myokardu bez ST elevací diagnóza mortalita terapie MeSH
- infarkt myokardu s elevacemi ST úseků diagnóza mortalita terapie MeSH
- inhibitory agregace trombocytů škodlivé účinky terapeutické užití MeSH
- koronární angioplastika * škodlivé účinky mortalita MeSH
- koronární bypass * škodlivé účinky mortalita MeSH
- krvácení chemicky indukované MeSH
- lékařská praxe - způsoby provádění MeSH
- lidé středního věku MeSH
- lidé MeSH
- mortalita v nemocnicích MeSH
- nestabilní angina pectoris diagnóza mortalita terapie MeSH
- prognóza MeSH
- recidiva MeSH
- registrace MeSH
- rizikové faktory MeSH
- senioři MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
- pozorovací studie MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Evropa epidemiologie MeSH
Aims: Among patients with acute coronary syndromes (ACS), those with diabetes mellitus (DM) are at particularly high risk of recurrent cardiovascular events and premature death. We aimed to provide a descriptive overview of unadjusted analyses of patient characteristics, ACS management, and outcomes up to 1 year after hospital admission for an ACS/index-ACS event, in patients with DM in contemporary registries in Europe. Methods and results: A total of 10 registries provided data in a systematic manner on ACS patients with DM (total n =28 899), and without DM (total n= 97 505). In the DM population, the proportion of patients with ST-Segment Elevation Myocardial Infarction (STEMI) ranged from 22.1% to 64.6% (other patients had non-ST-Segment Elevation Myocardial Infarction (NSTEMI-ACS) or unstable angina). All-cause mortality in the registries ranged from 1.4% to 9.4% in-hospital; 2.8% to 7.9% at 30 days post-discharge; 5.1% to 10.7% at 180 days post-discharge; and 3.3% to 10.5% at 1 year post-discharge. Major bleeding events were reported in up to 3.8% of patients while in hospital (8 registries); up to 1.3% at 30 days (data from two registries only), and 2.0% at 1 year (one registry only). Registries differed substantially in terms of study setting, site, patient selection, definition and schedule of endpoints, and use of various P2Y12 inhibitors. In most, but not all, registries, event rates in DM patients were higher than in patients without DM. Pooled risk ratios comparing cohorts with DM vs. no DM were in-hospital significantly higher in DM for all-cause death (1.66; 95% CI 1.42-1.94), for cardiovascular death (2.33; 1.78 - 3.03), and for major bleeding (1.35; 1.21-1.52). Conclusion: These registry data from real-life clinical practice confirm a high risk for recurrent events among DM patients with ACS, with great variation across the different registries.
2nd Department of Medicine with Cardiology and Intensive Care Hospital Rudolfstiftung Vienna Austria
AMIS Plus Data Center University of Zurich Zurich Switzerland
Cardiocenter 3rd Faculty of Medicine Charles University Prague Czech Republic
Cardiology Department Hospital La Paz Madrid Spain IdiPaz
Cardiology Freeman Hospital and Institute of Cellular Medicine Newcastle upon Tyne UK
Cardiology Service Hospital Universitari Vall d'Hebron Barcelona Spain
Cardiology Unit Humanitas Research Hospital Rozzano Italy
Department of Cardiology Clinical Sciences Lund University Skåne University Hospital Lund Sweden
Department of Cardiology Leiden University Medical Center Leiden The Netherlands
Department of Cardiology University Hospital Antwerp Edegem Belgium
Klinikum Ludwigshafen and Institut für Herzinfarktforschung Ludwigshafen Germany
Citace poskytuje Crossref.org
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- $a Diabetic patients with acute coronary syndromes in contemporary European registries: characteristics and outcomes / $c M. Lettino, P. Andell, U. Zeymer, P. Widimsky, N. Danchin, A. Bardaji, JA. Barrabes, A. Cequier, MJ. Claeys, L. De Luca, J. Dörler, D. Erlinge, P. Erne, P. Goldstein, SM. Koul, G. Lemesle, TF. Lüscher, CM. Matter, G. Montalescot, D. Radovanovic, JL. Sendón, P. Tousek, F. Weidinger, CFM. Weston, A. Zaman, J. Li, JW. Jukema, . ,
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- $a Aims: Among patients with acute coronary syndromes (ACS), those with diabetes mellitus (DM) are at particularly high risk of recurrent cardiovascular events and premature death. We aimed to provide a descriptive overview of unadjusted analyses of patient characteristics, ACS management, and outcomes up to 1 year after hospital admission for an ACS/index-ACS event, in patients with DM in contemporary registries in Europe. Methods and results: A total of 10 registries provided data in a systematic manner on ACS patients with DM (total n =28 899), and without DM (total n= 97 505). In the DM population, the proportion of patients with ST-Segment Elevation Myocardial Infarction (STEMI) ranged from 22.1% to 64.6% (other patients had non-ST-Segment Elevation Myocardial Infarction (NSTEMI-ACS) or unstable angina). All-cause mortality in the registries ranged from 1.4% to 9.4% in-hospital; 2.8% to 7.9% at 30 days post-discharge; 5.1% to 10.7% at 180 days post-discharge; and 3.3% to 10.5% at 1 year post-discharge. Major bleeding events were reported in up to 3.8% of patients while in hospital (8 registries); up to 1.3% at 30 days (data from two registries only), and 2.0% at 1 year (one registry only). Registries differed substantially in terms of study setting, site, patient selection, definition and schedule of endpoints, and use of various P2Y12 inhibitors. In most, but not all, registries, event rates in DM patients were higher than in patients without DM. Pooled risk ratios comparing cohorts with DM vs. no DM were in-hospital significantly higher in DM for all-cause death (1.66; 95% CI 1.42-1.94), for cardiovascular death (2.33; 1.78 - 3.03), and for major bleeding (1.35; 1.21-1.52). Conclusion: These registry data from real-life clinical practice confirm a high risk for recurrent events among DM patients with ACS, with great variation across the different registries.
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