Detail
Article
Online article
FT
Medvik - BMC
  • Something wrong with this record ?

Spatial navigation deficits - overlooked cognitive marker for preclinical Alzheimer disease?

G. Coughlan, J. Laczó, J. Hort, AM. Minihane, M. Hornberger,

. 2018 ; 14 (8) : 496-506. [pub] -

Language English Country England, Great Britain

Document type Journal Article, Review

E-resources Online Full text

NLK ProQuest Central from 2009-04-01 to 1 year ago
Health & Medicine (ProQuest) from 2009-04-01 to 1 year ago

Detection of incipient Alzheimer disease (AD) pathophysiology is critical to identify preclinical individuals and target potentially disease-modifying therapies towards them. Current neuroimaging and biomarker research is strongly focused in this direction, with the aim of establishing AD fingerprints to identify individuals at high risk of developing this disease. By contrast, cognitive fingerprints for incipient AD are virtually non-existent as diagnostics and outcomes measures are still focused on episodic memory deficits as the gold standard for AD, despite their low sensitivity and specificity for identifying at-risk individuals. This Review highlights a novel feature of cognitive evaluation for incipient AD by focusing on spatial navigation and orientation deficits, which are increasingly shown to be present in at-risk individuals. Importantly, the navigation system in the brain overlaps substantially with the regions affected by AD in both animal models and humans. Notably, spatial navigation has fewer verbal, cultural and educational biases than current cognitive tests and could enable a more uniform, global approach towards cognitive fingerprints of AD and better cognitive treatment outcome measures in future multicentre trials. The current Review appraises the available evidence for spatial navigation and/or orientation deficits in preclinical, prodromal and confirmed AD and identifies research gaps and future research priorities.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc19035140
003      
CZ-PrNML
005      
20191015111920.0
007      
ta
008      
191007s2018 enk f 000 0|eng||
009      
AR
024    7_
$a 10.1038/s41582-018-0031-x $2 doi
035    __
$a (PubMed)29980763
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a enk
100    1_
$a Coughlan, Gillian $u Norwich Medical School, University of East Anglia, Norwich, UK.
245    10
$a Spatial navigation deficits - overlooked cognitive marker for preclinical Alzheimer disease? / $c G. Coughlan, J. Laczó, J. Hort, AM. Minihane, M. Hornberger,
520    9_
$a Detection of incipient Alzheimer disease (AD) pathophysiology is critical to identify preclinical individuals and target potentially disease-modifying therapies towards them. Current neuroimaging and biomarker research is strongly focused in this direction, with the aim of establishing AD fingerprints to identify individuals at high risk of developing this disease. By contrast, cognitive fingerprints for incipient AD are virtually non-existent as diagnostics and outcomes measures are still focused on episodic memory deficits as the gold standard for AD, despite their low sensitivity and specificity for identifying at-risk individuals. This Review highlights a novel feature of cognitive evaluation for incipient AD by focusing on spatial navigation and orientation deficits, which are increasingly shown to be present in at-risk individuals. Importantly, the navigation system in the brain overlaps substantially with the regions affected by AD in both animal models and humans. Notably, spatial navigation has fewer verbal, cultural and educational biases than current cognitive tests and could enable a more uniform, global approach towards cognitive fingerprints of AD and better cognitive treatment outcome measures in future multicentre trials. The current Review appraises the available evidence for spatial navigation and/or orientation deficits in preclinical, prodromal and confirmed AD and identifies research gaps and future research priorities.
650    _2
$a Alzheimerova nemoc $x diagnóza $x patofyziologie $7 D000544
650    _2
$a zvířata $7 D000818
650    12
$a biologické markery $7 D015415
650    _2
$a lidé $7 D006801
650    12
$a prodromální symptomy $7 D062706
650    _2
$a prostorová navigace $x fyziologie $7 D065854
655    _2
$a časopisecké články $7 D016428
655    _2
$a přehledy $7 D016454
700    1_
$a Laczó, Jan $u Memory Clinic, Department of Neurology, Charles University, Second Faculty of Medicine and Motol University Hospital, Prague, Czech Republic. International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic.
700    1_
$a Hort, Jakub $u Memory Clinic, Department of Neurology, Charles University, Second Faculty of Medicine and Motol University Hospital, Prague, Czech Republic. International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic.
700    1_
$a Minihane, Anne-Marie $u Norwich Medical School, University of East Anglia, Norwich, UK.
700    1_
$a Hornberger, Michael $u Norwich Medical School, University of East Anglia, Norwich, UK. m.hornberger@uea.ac.uk. Dementia and Complexity in Later Life, NHS Norfolk and Suffolk Foundation Trust, Norfolk, UK. m.hornberger@uea.ac.uk.
773    0_
$w MED00185915 $t Nature reviews. Neurology $x 1759-4766 $g Roč. 14, č. 8 (2018), s. 496-506
856    41
$u https://pubmed.ncbi.nlm.nih.gov/29980763 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20191007 $b ABA008
991    __
$a 20191015112346 $b ABA008
999    __
$a ok $b bmc $g 1451800 $s 1073690
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2018 $b 14 $c 8 $d 496-506 $e - $i 1759-4766 $m Nature reviews. Neurology $n Nat Rev Neurol $x MED00185915
LZP    __
$a Pubmed-20191007

Find record

Citation metrics

Loading data ...

Archiving options

Loading data ...