-
Je něco špatně v tomto záznamu ?
Spatial navigation deficits - overlooked cognitive marker for preclinical Alzheimer disease?
G. Coughlan, J. Laczó, J. Hort, AM. Minihane, M. Hornberger,
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, přehledy
NLK
ProQuest Central
od 2009-04-01 do Před 1 rokem
Health & Medicine (ProQuest)
od 2009-04-01 do Před 1 rokem
- MeSH
- Alzheimerova nemoc diagnóza patofyziologie MeSH
- biologické markery * MeSH
- lidé MeSH
- prodromální symptomy * MeSH
- prostorová navigace fyziologie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
Detection of incipient Alzheimer disease (AD) pathophysiology is critical to identify preclinical individuals and target potentially disease-modifying therapies towards them. Current neuroimaging and biomarker research is strongly focused in this direction, with the aim of establishing AD fingerprints to identify individuals at high risk of developing this disease. By contrast, cognitive fingerprints for incipient AD are virtually non-existent as diagnostics and outcomes measures are still focused on episodic memory deficits as the gold standard for AD, despite their low sensitivity and specificity for identifying at-risk individuals. This Review highlights a novel feature of cognitive evaluation for incipient AD by focusing on spatial navigation and orientation deficits, which are increasingly shown to be present in at-risk individuals. Importantly, the navigation system in the brain overlaps substantially with the regions affected by AD in both animal models and humans. Notably, spatial navigation has fewer verbal, cultural and educational biases than current cognitive tests and could enable a more uniform, global approach towards cognitive fingerprints of AD and better cognitive treatment outcome measures in future multicentre trials. The current Review appraises the available evidence for spatial navigation and/or orientation deficits in preclinical, prodromal and confirmed AD and identifies research gaps and future research priorities.
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc19035140
- 003
- CZ-PrNML
- 005
- 20191015111920.0
- 007
- ta
- 008
- 191007s2018 enk f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1038/s41582-018-0031-x $2 doi
- 035 __
- $a (PubMed)29980763
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a enk
- 100 1_
- $a Coughlan, Gillian $u Norwich Medical School, University of East Anglia, Norwich, UK.
- 245 10
- $a Spatial navigation deficits - overlooked cognitive marker for preclinical Alzheimer disease? / $c G. Coughlan, J. Laczó, J. Hort, AM. Minihane, M. Hornberger,
- 520 9_
- $a Detection of incipient Alzheimer disease (AD) pathophysiology is critical to identify preclinical individuals and target potentially disease-modifying therapies towards them. Current neuroimaging and biomarker research is strongly focused in this direction, with the aim of establishing AD fingerprints to identify individuals at high risk of developing this disease. By contrast, cognitive fingerprints for incipient AD are virtually non-existent as diagnostics and outcomes measures are still focused on episodic memory deficits as the gold standard for AD, despite their low sensitivity and specificity for identifying at-risk individuals. This Review highlights a novel feature of cognitive evaluation for incipient AD by focusing on spatial navigation and orientation deficits, which are increasingly shown to be present in at-risk individuals. Importantly, the navigation system in the brain overlaps substantially with the regions affected by AD in both animal models and humans. Notably, spatial navigation has fewer verbal, cultural and educational biases than current cognitive tests and could enable a more uniform, global approach towards cognitive fingerprints of AD and better cognitive treatment outcome measures in future multicentre trials. The current Review appraises the available evidence for spatial navigation and/or orientation deficits in preclinical, prodromal and confirmed AD and identifies research gaps and future research priorities.
- 650 _2
- $a Alzheimerova nemoc $x diagnóza $x patofyziologie $7 D000544
- 650 _2
- $a zvířata $7 D000818
- 650 12
- $a biologické markery $7 D015415
- 650 _2
- $a lidé $7 D006801
- 650 12
- $a prodromální symptomy $7 D062706
- 650 _2
- $a prostorová navigace $x fyziologie $7 D065854
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a přehledy $7 D016454
- 700 1_
- $a Laczó, Jan $u Memory Clinic, Department of Neurology, Charles University, Second Faculty of Medicine and Motol University Hospital, Prague, Czech Republic. International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic.
- 700 1_
- $a Hort, Jakub $u Memory Clinic, Department of Neurology, Charles University, Second Faculty of Medicine and Motol University Hospital, Prague, Czech Republic. International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic.
- 700 1_
- $a Minihane, Anne-Marie $u Norwich Medical School, University of East Anglia, Norwich, UK.
- 700 1_
- $a Hornberger, Michael $u Norwich Medical School, University of East Anglia, Norwich, UK. m.hornberger@uea.ac.uk. Dementia and Complexity in Later Life, NHS Norfolk and Suffolk Foundation Trust, Norfolk, UK. m.hornberger@uea.ac.uk.
- 773 0_
- $w MED00185915 $t Nature reviews. Neurology $x 1759-4766 $g Roč. 14, č. 8 (2018), s. 496-506
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/29980763 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20191007 $b ABA008
- 991 __
- $a 20191015112346 $b ABA008
- 999 __
- $a ok $b bmc $g 1451800 $s 1073690
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2018 $b 14 $c 8 $d 496-506 $e - $i 1759-4766 $m Nature reviews. Neurology $n Nat Rev Neurol $x MED00185915
- LZP __
- $a Pubmed-20191007