Flavovirin--a new antifungal antibiotic produced by the pyrenomycete Melanconis flavovirens
Language English Country Germany Media print
Document type Comparative Study, Journal Article
- MeSH
- Amino Alcohols analysis MeSH
- Amino Acids analysis MeSH
- Antifungal Agents analysis isolation & purification pharmacology MeSH
- Ascomycota metabolism MeSH
- Fermentation MeSH
- Mass Spectrometry MeSH
- Fungi drug effects MeSH
- Yeasts drug effects MeSH
- Fatty Acids, Monounsaturated isolation & purification MeSH
- Magnetic Resonance Spectroscopy MeSH
- Molecular Structure MeSH
- Spectrophotometry, Infrared MeSH
- Publication type
- Journal Article MeSH
- Comparative Study MeSH
- Names of Substances
- Amino Alcohols MeSH
- Amino Acids MeSH
- Antifungal Agents MeSH
- flavovirin MeSH Browser
- Fatty Acids, Monounsaturated MeSH
- thermozymocidin MeSH Browser
The pyrenomycete Melanconis flavovirens was found to produce a mixture of two antifungal antibiotics. The first has been already described; the antibiotic is identical with thermozymocidin (myriocin). The second antibiotic is a new compound, whose isolation and identification is presented in this paper. The chemical structure of this substance (C21H37NO5) was determined to be 2-amino-2-hydroxymethyl-3,4-trans-epoxy-14-oxo-eicos-trans-6-enoic acid. After the producer it was named flavovirin and it possesses strong activity against yeasts and a moderate effectivity against filamentous fungi.
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Compounds isolated at the Institute of Microbiology in 1989-2001 and future trends
