Influence of chronic mercury poisoning upon the connective tissue in rats. II. Effect of mercuric chloride on collagen and elastin
Language English Country Czech Republic Media print
Document type Journal Article
PubMed
7697026
Knihovny.cz E-resources
- MeSH
- Mercuric Chloride toxicity MeSH
- Chronic Disease MeSH
- Elastin metabolism MeSH
- Collagen metabolism MeSH
- Rats MeSH
- Mercury Poisoning metabolism MeSH
- Rats, Wistar MeSH
- Tissue Distribution MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Names of Substances
- Mercuric Chloride MeSH
- Elastin MeSH
- Collagen MeSH
Rats were intoxicated with mercuric chloride (1 mg/kg b.w.) daily, for 12 weeks. An increase of total collagen and elastin content was found in the skin, the lungs, the liver, the kidneys and the heart muscle. The increase resulted from the elevated level of soluble collagen. These changes were accompanied by elevated hydroxyproline level in serum and urine. It is concluded that chronic intoxication with mercury leads to disturbed composition of the connective tissue matrix.
