Prolonged survival of AVN Wistar rats with transplanted Yoshida sarcoma and increase of granular lymphocytes after administration of Bacillus firmus and their crude lipids
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
8763155
DOI
10.1007/bf02814749
Knihovny.cz E-resources
- MeSH
- Adjuvants, Immunologic therapeutic use MeSH
- Immunotherapy, Active * MeSH
- B-Lymphocytes drug effects immunology MeSH
- Bacillus chemistry immunology MeSH
- Bacterial Vaccines immunology isolation & purification therapeutic use MeSH
- Rats MeSH
- Lipids immunology isolation & purification therapeutic use MeSH
- Lymphocyte Count MeSH
- Lymphocyte Subsets immunology MeSH
- Rats, Wistar MeSH
- Sarcoma, Yoshida pathology therapy MeSH
- Neoplasm Transplantation MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Adjuvants, Immunologic MeSH
- Bacterial Vaccines MeSH
- Lipids MeSH
Bacillus firmus is a Gram-positive, aerobic, sporulating, nonpathogenic air contaminant which, according to earlier findings, is a strong polyclonal activator of B lymphocytes. The crude lipids of this microbe induced significant resistance of mice against listerial infection. The administration of bacterin, like that of crude lipids obtained by the extraction of cell suspension with chloroform-methanol to rats, strain AVN Wistar, transplanted later with Yoshida sarcoma, significantly prolonged the survival of the animals in comparison with the control group. At the same time the number of granular lymphocytes was increased. The destruction of tumor cells in the peritoneal exudate of immunostimulated rats was also determined.
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