Lincomycin, cultivation of producing strains and biosynthesis
Applied microbiology and biotechnology.
2004 Feb ;
63 (5) :
510-9.
[epub] 20031031
Language English Country Germany Media print-electronic
Document type Journal Article, Review
Persistent link
https://www.medvik.cz/link/pmid14593504
- MeSH
- Genes, Bacterial MeSH
- Biomass MeSH
- Time Factors MeSH
- Chromatography MeSH
- Glucose metabolism MeSH
- Citric Acid metabolism MeSH
- Lincomycin biosynthesis chemistry isolation & purification MeSH
- Multigene Family MeSH
- Gene Order MeSH
- Streptomyces genetics growth & development metabolism MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
- Names of Substances
- Glucose MeSH
- Citric Acid MeSH
- Lincomycin MeSH
Lincomycin and its derivatives are antibiotics exhibiting biological activity against Gram-positive bacteria. The semi-synthetic chlorinated lincomycin derivative is used in clinical practice. The chemical structure of lincosamide antibiotics, cultivation of producing strains and analytical procedures used for separation and isolation of these compounds are described in this review. Biosynthesis of lincomycin and related compounds and its genetic control are briefly discussed.
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