Synthesis and transdermal penetration-enhancing activity of carbonic and carbamic acid esters--comparison with transkarbam 12
Language English Country England, Great Britain Media print-electronic
Document type Comparative Study, Journal Article, Research Support, Non-U.S. Gov't
PubMed
16446088
DOI
10.1016/j.bmcl.2005.12.086
PII: S0960-894X(06)00020-5
Knihovny.cz E-resources
- MeSH
- Administration, Cutaneous MeSH
- Esters MeSH
- Carbamates chemical synthesis chemistry pharmacology MeSH
- Rats MeSH
- Carbonic Acid chemical synthesis chemistry pharmacology MeSH
- Permeability MeSH
- Swine MeSH
- Chromatography, High Pressure Liquid MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Comparative Study MeSH
- Names of Substances
- carbamic acid MeSH Browser
- Esters MeSH
- Carbamates MeSH
- Carbonic Acid MeSH
- transkarbam 12 MeSH Browser
Transkarbam 12 (T12) is a novel transdermal penetration enhancer with high activity. Its polar head group is formed by carbamic acid salt that is unstable in acidic environment and releases CO(2). To find out whether this property influences its high activity, two series of compounds with CO(2) stronger bound in the polar head have been prepared-carbonic and carbamic acid esters. The carbamate salt in the polar head was found to be essential for the enhancing activity and its decomposition in an acidic environment suggested relating to the mode of action of T12.
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