Influence of silymarin and its flavonolignans on H(2)O(2)-induced oxidative stress in human keratinocytes and mouse fibroblasts
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
17011711
DOI
10.1016/j.burns.2006.04.004
PII: S0305-4179(06)00122-7
Knihovny.cz E-resources
- MeSH
- Fibroblasts metabolism MeSH
- Flavonolignans chemistry pharmacology MeSH
- Flavonols chemistry pharmacology MeSH
- Phytotherapy MeSH
- Keratinocytes metabolism MeSH
- Cells, Cultured MeSH
- Humans MeSH
- Mice, Inbred BALB C MeSH
- Mice MeSH
- Protective Agents pharmacology MeSH
- Oxidative Stress drug effects MeSH
- Oxidants adverse effects MeSH
- Hydrogen Peroxide adverse effects MeSH
- Quercetin analogs & derivatives chemistry pharmacology MeSH
- Plant Extracts chemistry pharmacology MeSH
- Silybin MeSH
- Silymarin chemistry pharmacology MeSH
- Dose-Response Relationship, Drug MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- dehydrosilybin MeSH Browser
- Flavonolignans MeSH
- Flavonols MeSH
- Protective Agents MeSH
- Oxidants MeSH
- Hydrogen Peroxide MeSH
- Quercetin MeSH
- Plant Extracts MeSH
- Silybin MeSH
- Silymarin MeSH
- taxifolin MeSH Browser
The administration of antioxidants has been shown to enhance repair and healing processes in cutaneous tissue. Silymarin, an extract from Silybum marianum has been reported to be beneficial in the treatment of chemically-induced oxidative stress in mouse. In this study, we investigated the protective effects of silymarin, its flavonolignans silybin and dehydrosilybin and flavonoids quercetin and taxifolin against hydrogen peroxide-induced damage to human keratinocytes and mouse fibroblasts. The results showed that the cytotoxicity of hydrogen peroxide was dose-dependent in both cell lines. Pre-treatment with test compounds decreased oxidative injury. Dehydrosilybin and quercetin were the most powerful protectants. Silymarin was comparable to silybinin, its main component. This correlates with the antioxidant potential of the compounds. Our findings suggest that silymarin, flavonolignans and flavonoids may be useful as agents for improving skin tissue regeneration.
References provided by Crossref.org
Modulation of Skin Inflammatory Response by Active Components of Silymarin
