Glycosylation patterns of HIV-1 gp120 depend on the type of expressing cells and affect antibody recognition
Jazyk angličtina Země Spojené státy americké Médium print-electronic
Typ dokumentu časopisecké články, Research Support, N.I.H., Extramural, práce podpořená grantem
Grantová podpora
U01 AI067854
NIAID NIH HHS - United States
U01 AI028147
NIAID NIH HHS - United States
DK054495
NIDDK NIH HHS - United States
R24 DK064400
NIDDK NIH HHS - United States
RR-20136
NCRR NIH HHS - United States
P01 AI071739
NIAID NIH HHS - United States
U19 AI028147
NIAID NIH HHS - United States
R01 DK047322
NIDDK NIH HHS - United States
T35 HL007473
NHLBI NIH HHS - United States
P01 AI083027
NIAID NIH HHS - United States
AI071739
NIAID NIH HHS - United States
R01 GM098539
NIGMS NIH HHS - United States
AI083027
NIAID NIH HHS - United States
R21 AI078477
NIAID NIH HHS - United States
AI078477
NIAID NIH HHS - United States
C06 RR020136
NCRR NIH HHS - United States
AI067854
NIAID NIH HHS - United States
R01 DK054495
NIDDK NIH HHS - United States
DK047322
NIDDK NIH HHS - United States
P01 AI028147
NIAID NIH HHS - United States
U19 AI067854
NIAID NIH HHS - United States
PubMed
20439465
PubMed Central
PMC2898351
DOI
10.1074/jbc.m109.085472
PII: S0021-9258(20)57373-0
Knihovny.cz E-zdroje
- MeSH
- AIDS imunologie MeSH
- buněčné linie MeSH
- buňky Hep G2 metabolismus MeSH
- ELISA metody MeSH
- glykosidhydrolasy metabolismus MeSH
- glykosylace MeSH
- HIV obalový protein gp120 genetika imunologie izolace a purifikace metabolismus MeSH
- HIV séropozitivita imunologie metabolismus MeSH
- HIV-1 imunologie metabolismus MeSH
- hmotnostní spektrometrie MeSH
- Jurkat buňky metabolismus MeSH
- komplementární DNA genetika MeSH
- lektin vázající mannosu genetika MeSH
- lidé MeSH
- mannosa metabolismus MeSH
- nádorové buněčné linie MeSH
- oligosacharidy chemie izolace a purifikace MeSH
- plazmidy MeSH
- polysacharidy chemie izolace a purifikace MeSH
- protilátky imunologie MeSH
- specificita protilátek MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Research Support, N.I.H., Extramural MeSH
- Názvy látek
- glykosidhydrolasy MeSH
- gp120 protein, Human immunodeficiency virus 1 MeSH Prohlížeč
- HIV obalový protein gp120 MeSH
- komplementární DNA MeSH
- lektin vázající mannosu MeSH
- mannosa MeSH
- oligosacharidy MeSH
- polysacharidy MeSH
- protilátky MeSH
Human immunodeficiency virus type 1 (HIV-1) entry is mediated by the interaction between a variably glycosylated envelope glycoprotein (gp120) and host-cell receptors. Approximately half of the molecular mass of gp120 is contributed by N-glycans, which serve as potential epitopes and may shield gp120 from immune recognition. The role of gp120 glycans in the host immune response to HIV-1 has not been comprehensively studied at the molecular level. We developed a new approach to characterize cell-specific gp120 glycosylation, the regulation of glycosylation, and the effect of variable glycosylation on antibody reactivity. A model oligomeric gp120 was expressed in different cell types, including cell lines that represent host-infected cells or cells used to produce gp120 for vaccination purposes. N-Glycosylation of gp120 varied, depending on the cell type used for its expression and the metabolic manipulation during expression. The resultant glycosylation included changes in the ratio of high-mannose to complex N-glycans, terminal decoration, and branching. Differential glycosylation of gp120 affected envelope recognition by polyclonal antibodies from the sera of HIV-1-infected subjects. These results indicate that gp120 glycans contribute to antibody reactivity and should be considered in HIV-1 vaccine design.
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