Neurosteroid modulation of N-methyl-D-aspartate receptors: molecular mechanism and behavioral effects
Language English Country United States Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
21925193
DOI
10.1016/j.steroids.2011.09.002
PII: S0039-128X(11)00280-7
Knihovny.cz E-resources
- MeSH
- Behavior * MeSH
- Humans MeSH
- Disease MeSH
- Neurotransmitter Agents chemistry metabolism MeSH
- Receptors, GABA metabolism MeSH
- Receptors, N-Methyl-D-Aspartate metabolism MeSH
- Steroids metabolism MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Neurotransmitter Agents MeSH
- Receptors, GABA MeSH
- Receptors, N-Methyl-D-Aspartate MeSH
- Steroids MeSH
Glutamate is the main neurotransmitter released at synapses in the central nervous system of vertebrates. Its excitatory role is mediated through activation of specific glutamatergic ionotropic receptors, among which the N-methyl-D-aspartate (NMDA) receptor subtype has attracted considerable attention in recent years. Substantial progress has been made in elucidating the roles these receptors play under physiological and pathological conditions and in our understanding of the functional, structural, and pharmacological properties of NMDA receptors. Many pharmacological compounds have been identified that affect the activity of NMDA receptors, including neurosteroids. This review summarizes our knowledge about molecular mechanisms underlying the neurosteroid action at NMDA receptors as well as about the action of neurosteroids in animal models of human diseases.
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