The course of heart failure development and mortality in rats with volume overload due to aorto-caval fistula
Language English Country Switzerland Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
22116309
DOI
10.1159/000331562
PII: 000331562
Knihovny.cz E-resources
- MeSH
- Aorta, Abdominal abnormalities MeSH
- Arteriovenous Fistula complications mortality physiopathology MeSH
- Cardiomegaly etiology mortality physiopathology MeSH
- Rats MeSH
- Survival Rate trends MeSH
- Rats, Wistar MeSH
- Heart Failure etiology mortality physiopathology MeSH
- Vena Cava, Inferior abnormalities MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
BACKGROUND: There are only few studies documenting the long-term outcome of aorto-caval fistula (ACF) in rats, a model of volume overload heart failure (HF). The aim of the present study was to describe HF-related morbidity and mortality, and to examine the relation between cardiac hypertrophy and survival. METHODS: Adult male Wistar rats underwent needle ACF or sham operation and 71 animals surviving the acute procedure with patent ACF were followed for 52 weeks. RESULTS: By the end of the study, 72% of the ACF animals deceased and 82% developed HF signs. Of the HF rats, 65% died (median: 3 weeks after HF onset). Before death, body weight increased by 9% followed by a final drop. 28% ACF rats died suddenly, without preceding HF. Sudden death occurred earlier and in the rats with a trend to larger hearts (p = 0.07). In the whole ACF cohort, heart weight (heart weight/body weight ratio) was inversely associated with the length of survival (r = -0.51, p < 0.001). CONCLUSION: The median survival of ACF Wistar rats is 43 weeks, longer than reported in other rat strains. Increased heart weight is associated with higher mortality and a significant number of animals die suddenly.
Department of Cardiology Institute for Clinical and Experimental Medicine IKEM Prague Czech Republic
References provided by Crossref.org
Anti-Fibrotic Potential of Angiotensin (1-7) in Hemodynamically Overloaded Rat Heart
Right versus left ventricular remodeling in heart failure due to chronic volume overload
