Tick as a model for the study of a primitive complement system
Language English Country United States Media print
Document type Journal Article, Research Support, Non-U.S. Gov't
- MeSH
- Phagocytosis MeSH
- Insect Vectors genetics immunology MeSH
- Insect Proteins genetics immunology MeSH
- Ixodes genetics immunology microbiology MeSH
- Complement System Proteins genetics immunology MeSH
- Lectins metabolism MeSH
- Molecular Sequence Data MeSH
- Immunity, Innate immunology MeSH
- RNA Interference MeSH
- Amino Acid Sequence MeSH
- Sequence Alignment MeSH
- Animals MeSH
- Check Tag
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Insect Proteins MeSH
- Complement System Proteins MeSH
- Lectins MeSH
Ticks are blood feeding parasites transmitting a wide variety of pathogens to their vertebrate hosts. The transmitted pathogens apparently evolved efficient mechanisms enabling them to evade or withstand the cellular or humoral immune responses within the tick vector. Despite its importance, our knowledge of tick innate immunity still lags far beyond other well established invertebrate models, such as drosophila, horseshoe crab or mosquitoes. However, the recent release of the American deer tick, Ixodes scapularis, genome and feasibility of functional analysis based on RNA interference (RNAi) facilitate the development of this organism as a full-value model for deeper studies of vector-pathogen interactions.
References provided by Crossref.org
Serpins in Tick Physiology and Tick-Host Interaction
A bite so sweet: the glycobiology interface of tick-host-pathogen interactions
Sialomes and Mialomes: A Systems-Biology View of Tick Tissues and Tick-Host Interactions
Deep Sequencing Analysis of the Ixodes ricinus Haemocytome
Interaction of the tick immune system with transmitted pathogens
