Tick saliva facilitates tick feeding and infection of the host. Gene expression analysis of tick salivary glands and other tissues involved in host-pathogen interactions has revealed a wide range of bioactive tick proteins. Transcriptomic analysis has been a milestone in the field and has recently been enhanced by next-generation sequencing (NGS). Furthermore, the application of quantitative proteomics to ticks with unknown genomes has provided deeper insights into the molecular mechanisms underlying tick hematophagy, pathogen transmission, and tick-host-pathogen interactions. We review current knowledge on the transcriptomics and proteomics of tick tissues from a systems-biology perspective and discuss future challenges in the field.

Department of Biological Sciences The University of Southern Mississippi Hattiesburg MS USA

Department of Microbiology and Immunology University of Maryland School of Medicine Baltimore MD USA

Faculty of Science University of South Bohemia in České Budějovice Budweis Czech Republic; Department of Clinical Pathobiochemistry Technische Universität Dresden Dresden Germany

Faculty of Science University of South Bohemia in České Budějovice Budweis Czech Republic; Institute of Parasitology Biology Center Czech Academy of Sciences Budweis Czech Republic

Institute of Parasitology Biology Center Czech Academy of Sciences Budweis Czech Republic

Section of Vector Biology Laboratory of Malaria and Vector Research National Institute of Allergy and Infectious Diseases National Institutes of Health Rockville MD USA

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Genome sequences of four Ixodes species expands understanding of tick evolution

Insight Into the Dynamics of the Ixodes ricinus Nymphal Midgut Proteome

Tick Salivary Kunitz-Type Inhibitors: Targeting Host Hemostasis and Immunity to Mediate Successful Blood Feeding

Bioinformatic Analysis of Ixodes ricinus Long Non-Coding RNAs Predicts Their Binding Ability of Host miRNAs

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Tick Salivary Compounds for Targeted Immunomodulatory Therapy

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Tick-host conflict: immunoglobulin E antibodies to tick proteins in patients with anaphylaxis to tick bite

The Tick Protein Sialostatin L2 Binds to Annexin A2 and Inhibits NLRC4-Mediated Inflammasome Activation

All For One and One For All on the Tick-Host Battlefield

In Vitro Mode of Action and Anti-thrombotic Activity of Boophilin, a Multifunctional Kunitz Protease Inhibitor from the Midgut of a Tick Vector of Babesiosis, Rhipicephalus microplus