Comparison of acute toxicity of ketoprofen to juvenile and embryonic stages of Danio rerio
Jazyk angličtina Země Švédsko Médium print
Typ dokumentu srovnávací studie, časopisecké články, práce podpořená grantem
PubMed
22167210
PII: NEL32S111A14
Knihovny.cz E-zdroje
- MeSH
- antiflogistika nesteroidní škodlivé účinky toxicita MeSH
- dánio pruhované embryologie růst a vývoj MeSH
- embryo nesavčí MeSH
- inhibitory cyklooxygenasy škodlivé účinky toxicita MeSH
- ketoprofen škodlivé účinky toxicita MeSH
- LD50 MeSH
- permeabilita buněčné membrány účinky léků fyziologie MeSH
- preklinické hodnocení léčiv MeSH
- stadia vývoje účinky léků fyziologie MeSH
- testy akutní toxicity MeSH
- vztah mezi dávkou a účinkem léčiva MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- srovnávací studie MeSH
- Názvy látek
- antiflogistika nesteroidní MeSH
- inhibitory cyklooxygenasy MeSH
- ketoprofen MeSH
OBJECTIVES: Ketoprofen is a common human medicine from a class of non-steroidal anti-inflammatory drugs (NSAIDs), which is provably detected in surface waters in concentrations ordinarily in μg.L-1. The aim of this study was to compare the acute toxicity of ketoprofen to embryonic and juvenile stages of aquarium fish - zebrafish (Danio rerio). METHODS: Tests were performed according to the methods of the Organisation for Economic Co-operation and Development (OECD) No. 203 (Fish, acute toxicity test) and OECD No. 212 (Fish, short-term toxicity test on embryo and sac-fry stages). RESULTS: The results showed (mean ± SD) LC50 value of ketoprofen to be 632.30 ± 10.10 mg.L-1 in juvenile zebrafish and 6.44 ± 2.22 mg.L-1 in embryonic stages of zebrafish. The results revealed statistically significantly higher sensitivity (p<0.01) of the embryonic stages of zebrafish to ketoprofen compared to its juveniles. The susceptibility of embryos depends on many factors, especially yet improperly developed enzymatic system in embryos, different ways of the absorption of the substance into the organism or differences in metabolism pathways. CONCLUSIONS: The acute toxicity of ketoprofen for juvenile stages of zebrafish is low, but the substance seems to be toxic for embryonic stages.