Anti-infective and herbicidal activity of N-substituted 2-aminobenzothiazoles
Language English Country Great Britain, England Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't
PubMed
23140987
DOI
10.1016/j.bmc.2012.10.007
PII: S0968-0896(12)00808-5
Knihovny.cz E-resources
- MeSH
- Antifungal Agents metabolism pharmacology MeSH
- Anti-Infective Agents chemical synthesis chemistry pharmacology MeSH
- Antineoplastic Agents chemical synthesis chemistry pharmacology MeSH
- Benzothiazoles chemical synthesis chemistry pharmacology MeSH
- Chloroplasts drug effects MeSH
- Herbicides chemical synthesis chemistry pharmacology MeSH
- Drug Screening Assays, Antitumor MeSH
- Humans MeSH
- Microbial Sensitivity Tests MeSH
- Cell Line, Tumor MeSH
- Spinacia oleracea MeSH
- Structure-Activity Relationship MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Names of Substances
- Antifungal Agents MeSH
- Anti-Infective Agents MeSH
- Antineoplastic Agents MeSH
- Benzothiazoles MeSH
- Herbicides MeSH
In this study, a series of N-substituted 2-aminobenzothiazoles was prepared according to a recently developed method. Twelve compounds were tested for their activity related to the inhibition of photosynthetic electron transport (PET) in spinach (Spinacia oleracea L.) chloroplasts. Primary in vitro screening of the discussed compounds was also performed against fungal, bacterial and mycobacterial species. The biological activities of some compounds were comparable or higher than the standards phenoxymethylpenicillin or pyrazinamide. The most effective compounds demonstrated insignificant toxicity against the human monocytic leukemia THP-1 cell line. For all compounds, the structure-activity relationships are discussed.
References provided by Crossref.org
Trifluoromethylcinnamanilide Michael Acceptors for Treatment of Resistant Bacterial Infections
Photosynthesis-Inhibiting Activity of N-(Disubstituted-phenyl)-3-hydroxynaphthalene-2-carboxamides
Synthesis and Spectrum of Biological Activities of Novel N-arylcinnamamides
Proline-Based Carbamates as Cholinesterase Inhibitors
Preparation and biological properties of ring-substituted naphthalene-1-carboxanilides
Antibacterial and herbicidal activity of ring-substituted 2-hydroxynaphthalene-1-carboxanilides
Antibacterial and herbicidal activity of ring-substituted 3-hydroxynaphthalene-2-carboxanilides
